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Carboxylated porous polystyrene microspheres and preparation method thereof

A porous polystyrene and carboxylation technology, applied in the field of polymer microspheres, can solve the problems of unsatisfactory swelling effect, uneven distribution of functional groups, uneven size of microspheres, etc., and achieves good mechanical properties, uniform size, Evenly distributed effect

Active Publication Date: 2018-07-27
湖北新纵科病毒疾病工程技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The swelling effect of this one-step swelling method is not very ideal, the size of the final microspheres is not uniform, the distribution of functional groups is not uniform, etc., and the required swelling time is long

Method used

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  • Carboxylated porous polystyrene microspheres and preparation method thereof

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Embodiment 1

[0043] This embodiment provides a method for preparing carboxylated porous polystyrene microspheres, including:

[0044] 1) Take 2mL polystyrene seed microsphere solution (mass volume fraction 5% (w / v), solvent 0.25wt% SDS solution) and ultrasonically disperse it in 25mL sodium dodecyl sulfate SDS aqueous solution, take 128 μL cyclohexane ultrasonic Emulsified and dispersed in 15mL SDS aqueous solution, and added dropwise to the above dispersed seed microsphere solution, mixed with magnetic stirring and swelled at temperature T=30°C for 6h;

[0045] 2) Dissolve 0.1g of dibenzoyl peroxide BPO in 11mL of styrene, add 9.5mL of ethylene glycol dimethacrylate EGDMA, 0.5mL of methacrylic acid MAA, and 11.5mL of toluene in sequence, mix well and then add In the reaction system obtained in step 1), add 80 mL of SDS aqueous solution to it, and continue to swell for 10 h at a temperature T=30° C.;

[0046]3) Add 2 g of PVP, 400 μL of methylene blue aqueous solution, and 80 mL of ultrap...

Embodiment 2

[0050] This embodiment provides a kind of preparation method of carboxylated porous polystyrene microspheres, comprising:

[0051] 1) Get 2mL divinylbenzene cross-linked polystyrene microsphere solution (5% by mass volume fraction (w / v), solvent 0.25wt% SDS solution) and ultrasonically disperse in 25mL sodium dodecyl sulfate SDS aqueous solution, take 128 μL of cyclohexane was ultrasonically emulsified and dispersed in 15 mL of SDS aqueous solution, and added dropwise to the above dispersed seed microsphere solution, mixed with magnetic stirring and swelled at temperature T=30°C for 6 hours;

[0052] 2) Dissolve 0.1g of dibenzoyl peroxide BPO in 11mL of styrene, add 9.5mL of ethylene glycol dimethacrylate EGDMA, 0.5mL of methacrylic acid MAA, and 11.5mL of toluene in sequence, mix well and then add In the reaction system obtained in step 1), add 80 mL of SDS aqueous solution to it, and continue to swell for 10 h at a temperature T=30° C.;

[0053] 3) Add 2 g of PVP, 400 μL of...

Embodiment 3

[0057] This embodiment provides a kind of preparation method of carboxylated porous polystyrene microspheres, comprising:

[0058] 1) Take 2mL polystyrene seed microsphere solution (mass volume fraction 5% (w / v), solvent 0.25wt% SDS solution) and ultrasonically disperse it in 25mL sodium dodecyl sulfate SDS aqueous solution, take 128 μL cyclohexane ultrasonic Emulsified and dispersed in 15mL SDS aqueous solution, and added dropwise to the above dispersed seed microsphere solution, mixed with magnetic stirring and swelled at temperature T=40°C for 3h;

[0059] 2) Dissolve 0.1g of dibenzoyl peroxide BPO in 11mL of styrene, add 9.5mL of ethylene glycol dimethacrylate EGDMA, 0.5mL of methacrylic acid MAA, and 11.5mL of toluene in sequence, mix well and then add In the reaction system obtained in step 1), add 80 mL of SDS aqueous solution to it, and continue to swell for 20 h at a temperature T=40° C.;

[0060] 3) Add 2 g of PVP, 400 μL of methylene blue aqueous solution, and 80 m...

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Abstract

The invention provides carboxylated porous polystyrene microspheres and a preparation method thereof. The preparation method of the carboxylated porous polystyrene microspheres comprises steps as follows: 1), seed microspheres are swollen by cyclohexane; 2), the seed microspheres obtained in the step 1) are subjected to further swelling by styrene monomers, functional acrylic monomers, a crosslinking agent and a pore-foaming agent; a protective agent and an aqueous phase polymerization inhibitor are added to a system obtained after swelling in the step 2), and then a polymerization reaction isperformed; the seed microspheres are polystyrene microspheres. The carboxylated porous polystyrene microspheres obtained with the preparation method of the carboxylated porous polystyrene microspheres are not only uniform in size, but also contain rich and uniform carboxyl functional groups on the surfaces, and are of a uniform porous structure.

Description

technical field [0001] The invention relates to the technical field of polymer microspheres, in particular to a carboxylated porous polystyrene microsphere and a preparation method thereof. Background technique [0002] Liquid phase chip technology, also known as flow microbead technology, is to combine the soluble substance to be tested in the solution on the optically coded microsphere similar to the size of the cell through the specific affinity reaction between biomolecules. The instrument is a new generation of molecular diagnostic technology platform for simultaneous rapid qualitative and quantitative analysis of multiple components in the same trace sample. In European and American countries, liquid-phase chip technology, as an emerging diagnostic technology with superior performance, is constantly developing new clinical diagnostic applications, including pathogen detection, human leukocyte antigen (HLA) typing detection, cytokine detection, etc. The carrier of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/14C08J7/16C08J7/02
CPCC08J7/02C08J7/16C08J9/141C08J2203/14C08J2205/042C08J2325/06
Inventor 王华林张涛张科登
Owner 湖北新纵科病毒疾病工程技术有限公司
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