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Superfine composite fiber film, preparation method and use thereof

A technology of ultra-fine composite fibers and fiber membranes, applied in the fields of medical science, textiles and papermaking, bandages, etc., can solve problems such as dysfunction, artificial materials stay in the body, cannot be removed, etc., and achieve high porosity and suitable tissue adhesion. The effect of convenient performance and mechanical strength

Active Publication Date: 2012-05-02
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these patches physically separate the lesion by applying the patch to the lesion so that there are no adhesions, they are not absorbed in the body, thus creating the problem of retention of artificial materials in the body
In addition, the non-absorbent sheet or membrane thus pasted can itself cause dysfunction by adhering to the organ
In this case, such adhering to the organ will not be removed even by reoperation

Method used

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  • Superfine composite fiber film, preparation method and use thereof
  • Superfine composite fiber film, preparation method and use thereof
  • Superfine composite fiber film, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Solution preparation: PLGA (molecular weight is 80,000, wherein the molar ratio of lactide to glycolide is 95:5) and PELA (molecular weight is 10,000, wherein the molar ratio of polylactide to polyethylene glycol Ratio is 2: 8) is dissolved in the mixed solvent of N, N dimethylformamide (DMF) and acetone (volume ratio is 5: 5), obtains the mixing of PLGA and PELA that total polymer mass volume concentration is 50% solution. In the solution, the mass ratio of PLGA to PELA is 95:5.

[0032] (2) Electrospinning: the PLGA solution obtained in step (1) is placed in the feeding syringe of the electrospinning equipment. Adjust the distance between the spinneret and the roller to 12cm, the ambient temperature for spinning is 25°C, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr, turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20kV, and the feeding speed of the solution is 20 μl / min, and perform spinning. Th...

Embodiment 2

[0035] (1) Solution preparation: mix PLGA (molecular weight of 200,000, wherein the molar ratio of lactide to glycolide is 3:1) and PELA (molecular weight of 10,000, wherein the molar ratio of polylactide to polyethylene glycol Ratio is 50:50) is dissolved in the mixed solvent of N,N dimethylformamide (DMF) and acetone (volume ratio is 9:1), obtains the mixing of PLGA and PELA that total polymer mass volume concentration is 35% solution. In the solution, the mass ratio of PLGA to PELA is 80:20.

[0036] (2) Electrospinning: the PLGA solution obtained in step (1) is placed in the feeding syringe of the electrospinning equipment. Adjust the distance between the spinneret and the roller to 12cm, the ambient temperature for spinning is 25°C, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr, turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20kV, and the feeding speed of the solution is 20 μl / min, and perform spinning...

Embodiment 3

[0039] (1) Solution preparation: PLGA (molecular weight is 40,000, wherein the molar ratio of lactide to glycolide is 3:1) and PELA (molecular weight is 80,000, wherein the molar ratio of polylactide to polyethylene glycol Ratio is 9: 1) is dissolved in the mixed solvent of N, N dimethylformamide (DMF) and acetone (volume ratio is 1: 9), obtains the mixing of PLGA and PELA that total polymer mass volume concentration is 45wt% solution. In the solution, the mass ratio of PLGA to PELA is 75:25.

[0040] (2) Electrospinning: the PLGA solution obtained in step (1) is placed in the feeding syringe of the electrospinning equipment. Adjust the distance between the spinneret and the roller to 12cm, the ambient temperature for spinning is 25°C, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr, turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 20kV, and the feeding speed of the solution is 20 μl / min, and perform spinning. ...

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Abstract

The invention relates to a biodegradable and bioabsorbable superfine composite fiber film, which consists of poly lactic-co-glycolic acid of the weight ratio ranging from 75wt% to 100wt% and poly latic acid-b-polyethylene glycol of the weight ratio ranging from 0wt% to 25wt%. The preparation method includes the following steps of mixing the poly lactic-co-glycolic acid and the poly latic acid-b-polyethylene glycol into N, N-dimethylformamide or acetone or mixture of the N-dimethylformamide and the acetone so as to obtain uniform polymer solution, then stirring the uniform polymer solution at room temperature to obtain uniform mixed liquid, and finally injecting the uniform mixed liquid into an electrostatic spinning device to conduct electrostatic spinning, and accordingly the poly lactic-co-glycolic acid and the poly lactic acid-b-polyethylene glycol superfine composite fiber film is obtained. The superfine composite fiber film has excellent biocompatibility and adjustable biodegradation, has the advantages of light and soft texture and fine permeability simultaneously, and can be used as excellent internal adhesion-proof materials.

Description

technical field [0001] The present invention relates to a biodegradable and bioabsorbable postoperative anti-adhesion ultrafine composite fiber membrane, its preparation method and its application, in particular to a polylactide (PLGA) and polylactide-b- Ultrafine composite fiber membrane prepared from polyethylene glycol (PELA), its preparation method and its use. Background technique [0002] Postoperative adhesions are a scientific problem with high incidence and recurrence rates in the field of surgery. Complications caused by postoperative adhesions not only bring great pain to patients' daily life, but also greatly increase the risk of secondary surgery. Therefore, how to prevent postoperative adhesions and reduce the pain of patients has become a research topic in the medical field. For a long time, the medical community has done a lot of work in the research of preventing postoperative adhesions, and the most obvious effect is the physical isolation method. Curren...

Claims

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Application Information

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IPC IPC(8): D04H1/435D04H1/728A61L31/06A61L31/14A61L15/26A61L15/50
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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