Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method

A technology for relieving sore throat, relieving pain, clearing away heat and detoxification, applied in drug combination, medical formula, drug delivery, etc., can solve problems such as unfavorable quality control, excessive dosage, easy mildew and bacterial infection, etc., and achieve significant economic and social benefits , The effect of reducing the dosage of the patient and improving the bioavailability

Inactive Publication Date: 2012-06-06
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The preparation method of the drug is simple, but the original formulation is a honeyed pill, which is prone to mildew and bacterial contamination, which is not conducive to quality control
It is inconvenient for patients to take and carry, the taste is not good, each pill weighs 3 grams, and the dosage of each dose is too large, children have difficulty swallowing, and the patient's acceptance is poor
And the absorption process from oral administration to the gastrointestinal tract is slow

Method used

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  • Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method
  • Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method
  • Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: preparation of Chinese medicine extract

[0024] 1. Prescription: silkworm excrement 100g rhubarb 100g scrophulariaceae 100g saponins 100g red peony root 100g radix 100g forsythia 100g isatis root 100g rehmannia root 100g honeysuckle 100g rhizome root 100g peony bark 65g indigo 50g fritillaria 50g mint 50g licorice 33g.

[0025] Two. Preparation method:

[0026] Weigh each raw material according to the ratio of raw materials; extract all the medicinal materials with water twice, each time with 10 times the amount of water for 1.5 hours, combine the extracts, concentrate to a relative density of 1.08 at 50-60°C, and obtain a concentrated solution A; Add concentrated solution A to ethanol with a concentration of 60% by volume, stir evenly, place it for 12 hours, and filter to obtain supernatant B; concentrate supernatant B to a relative density of 1.08 at 50-60°C, dry, The dried product I was obtained, which was 562 grams of the active ingredient of the pre...

Embodiment 2

[0027] Embodiment 2: preparation of Chinese medicine extract

[0028] 1. Prescription: silkworm excrement 100g rhubarb 100g scrophulariaceae 100g saponins 100g red peony root 100g radix 100g forsythia 100g isatis root 100g rehmannia root 100g honeysuckle 100g rhizome root 100g peony bark 65g indigo 50g fritillaria 50g mint 50g licorice 33g.

[0029] Two. Preparation method:

[0030] Weigh each raw material according to the raw material ratio; extract all the medicinal materials with water twice, the first time with 10 times the amount of water for 2 hours, the second time with 8 times the amount of water for 1.5 hours, combine the extracts, and concentrate to 50-60 Under the condition of ℃, the relative density is 1.10, and the concentrated solution A is obtained; the concentrated solution A is added with ethanol with a concentration of 70% by volume, stirred evenly, left for 12 hours, and filtered to obtain the supernatant B; the supernatant B is concentrated to The relative...

Embodiment 3

[0031] Embodiment 3: preparation of Chinese medicine extract

[0032] 1. Prescription: silkworm excrement 100g rhubarb 100g scrophulariaceae 100g saponins 100g red peony root 100g radix 100g forsythia 100g isatis root 100g rehmannia root 100g honeysuckle 100g rhizome root 100g peony bark 65g indigo 50g fritillaria 50g mint 50g licorice 33g.

[0033] Two. Preparation method:

[0034] Weigh each raw material according to the ratio of raw materials; extract all the medicinal materials with water twice, each time with 10 times the amount of water for 2 hours, combine the extracts, concentrate to a relative density of 1.08 at 50-60°C, and obtain a concentrated solution A; add concentrated solution A to ethanol with a concentration of 60% by volume, stir evenly and place it for 12 hours, filter to obtain supernatant B; concentrate supernatant B to a relative density of 1.05 under the condition of 50-60°C, Dried to obtain dry matter I, which is 450 grams of the active ingredient of th...

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Abstract

The invention discloses a traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving the throat pain as well as its preparation method, which belongs to the traditional Chinese medicine modernization field. The active component of the traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving the throat pain comprises the following raw material by weight part: 100 parts of silkworm excrement, 100 parts of rheum officinale, 100 parts of radix scrophulariae, 100 parts of semen gleditsiae, 100 parts of radix paeoniae rubrathe, 100 parts of radix ophiopogonis, 100 parts of fructus forsythiae, 100 parts of dyer woad root, 100 parts of glutinous rehmannia, 100 parts of honeysuckle flower, 100 parts of imperata rhizome, 65 parts of tree peony bark, 50 parts of natural indigo, 50 parts of fritillaria cirrhosa, 50 parts of mint and 33 parts of licorice. The invention has the advantages that the quality is stable and controllable, compared with the present sold dosage form, the curative effect is substantially enhanced, the administration dosage by patients is minimized, the biology availability is increased, the method of the invention possesses substantial economical and social benefit.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for clearing heat, detoxifying, relieving sore throat and relieving pain and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] The prevalence of acute pharyngitis in children in my country is 0.5-2.0%, and it has been reported as high as 5.2%, and it has been increasing in recent years due to air pollution. Seriously endanger human physical and mental health, so patients come from a wide range of sources. Pathogenic microorganisms are mainly hemolytic streptococcus, pneumococcus, influenza bacillus and virus. The clinical manifestations are acute onset, with dryness and burning of the pharynx at the beginning, followed by pain, which aggravates when swallowing, and can radiate to the ear. Sometimes general malaise, joint pain, headache, loss of appetite, and varying degrees of fever. Body temperature can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/00A61K9/20A61K9/48A61P11/04A61K35/64
Inventor 潘勤江永萍宋立平李妍刘稚菲韩晓静
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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