Method for preparing Shenshuaining preparations with polymeric flocculation and precipitation technology

Abstract

The invention provides a method for preparing Shenshuaining preparations with a polymeric flocculation and precipitation technology. The method specifically comprises the following steps of: preparing the following bulk drugs: Radix Pseudostellariae, Coptis, prepared pinellia tuber, tangerine peel, Poria cocos, rhubarb, etc.; preparing rhubarb powder; preparing a rhubarb thick paste, adding a flocculating agent into a percolation solution; preparing a medicinal thick paste, and adding a flocculating agent into an extracting solution; preparing a mixed thick paste; mixing the mixed thick paste and the rhubarb powder uniformly; conducting drying and crushing so as to obtain Shenshuaining medicinal powder; preparing the Shenshuaining powder into capsules, tablets, granules, pulvis, and oral liquid preparations; conducting inspection on the preparations with high-performance liquid chromatography, taking a mobile phase composed of methanol and water (45:55), controlling the detection wavelength at 254nm and the theoretical plate number greater than or equal to 5000, with the total alkaloid content, in terms of berberine hydrochloride, greater than 3.2mg in per 0.35g of the preparations. The Shenshuaining preparations of the invention have enhanced chemical stability, stable product quality, better content homogeneity, very low content deviation, and greatly increased effective components. When the preparations are absorbed, the contents can be rapidly released, and the in vivo utilization rate and absorption rate are high.

Description

technical field [0001] The invention relates to a method for preparing a traditional Chinese medicine preparation, in particular to a method for preparing a Shenshuaining preparation by using polymer flocculation and precipitation technology. Background technique [0002] Chronic renal failure is the decline in renal function caused by various chronic kidney diseases. Due to the abnormal excretion and regulation of the kidneys, the extreme disturbance of water, electrolyte and acid-base balance, as well as the retention of nitrogen metabolites in the body, CRF is extremely harmful to people's health. One of the diseases is one of the key project topics that the medical field urgently needs to solve. At present, hemodialysis, peritoneal dialysis and kidney transplantation are mainly used in the treatment of CRF at home and abroad. The cost is high and it is a heavy burden on society, family and individual. Traditional Chinese medicine plays an important role in delaying the...

AI Technical Summary

Problems solved by technology

2. Alcohol-soluble ingredients such as alkaloids, glycosides, and flavonoids are not completely extracted, and are affected by the addition of alcohol during the impurity removal process, which causes the content to be significantly reduced.

3. Oral solid preparations, because polysaccharides and other substances are removed during alcohol precipitation, and several times the amount of starch, dextrin and other auxiliary materials need to be added after the alcohol is recovered and concentrated by ethanol, which not only wastes resources, but also greatly increases the cost.

The production cycle of water extraction and alcohol precipitation method is long, and the general production cycle is more than 4-5 days

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