Method for preparing efficient antibacterial tracheal intubation catheter

Abstract

The invention relates to the field of medical treatment, in particular to a technology of a silver loaded nano titanium dioxide (TIO2) medical polyethylene tracheal intubation catheter with the modified surface. The invention adopts an irradiation grafting reaction to modify the surface of the medical polyethylene intubation, and the surface modification is achieved through the steps: activating the surface of a base material, preparing silver loaded nano TIO2 hydrophobic antibacterial masking liquid, and conducting the antimicrobial modification to the surface of the base material and the like. The invention reduces the complicating diseases due to retention of the tracheal intubation catheter as far as possible, prolongs the catheter retention time, is suitable for clinical application, reduces the complicating diseases, lays the foundation of producing the tracheal intubation catheter with the independent intellectual property, is favor for conversion from nano fundamental researches to the clinical techniques researches, improves the production capability, gains time to successfully rescue patients, and can reduce the economic burden at the same time.

Description

technical field [0001] The invention relates to the medical field, specifically, a silver-loaded nano-titanium dioxide (TiO 2 ) surface modified medical polyethylene endotracheal tube catheter technology. Background technique [0002] Endotracheal intubation is the technique of inserting a special endotracheal tube into the trachea through the glottis. It is a simple and effective method to establish an unobstructed airway. In addition to general anesthesia patients, in the rescue process of many critically ill patients, in order to effectively carry out mechanical ventilation, remove sputum or blood in the trachea, prevent vomiting and suffocation, and relieve respiratory obstruction, tracheal intubation is often required. The artificial airway established by tracheal intubation has become the most important "lifeline" for patients. Critically ill patients who need emergency tracheal intubation in clinical first aid mainly include: [0003] 1. Spontaneous breathing stops...

AI Technical Summary

Problems solved by technology

[0004] 2. Those who cannot meet the body's ventilation and oxygen supply and need mechanical ventilation;

[0005] 3. Unable to clear upper respiratory tract secretions, reflux of gastric contents or bleeding at any time and aspiration;

[0006] 4. There are upper respiratory tract injuries, stenosis, obstruction, tracheoesophageal fistula, etc. that affect normal ventilation;

[0011] 2. Sputum scab blocks the medical polyethylene plastic endotracheal intubation catheter, which has high adhesion to liquid, and airway secretions such as sputum and blood are very easy to adhere to the surface of the catheter, and critically ill patients or patients using sedative and anesthetic drugs have sputum discharge obstacles , airway secretions adhering to the surface of the catheter form a scab

Although active artificial airway care, such as adequate humidification, heat preservation, and airway suction, can partially reduce sputum plugs and sputum scabs, it will aggravate airway mucosal damage and the formation of sputum scabs is still inevitable [4]

[0012] 3. Airway damage After endotracheal intubation, pressure, friction, and irritation between the catheter and the airway mucosa are prone to airway edema, bleeding, inflammation, and even airway corrosion, and the catheter is easy to become soft and twisted in the body. Poor ventilation, which affects the therapeutic effect

Raad II [6] found that the risk of ventilator-associated pneumonia can be reduced, but the adhesion of the surface of the catheter to airway secretions cannot be changed, which may easily lead to sputum plug obstruction of the endotracheal intubation