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Calibration method for multi-passage time domain fluorescence chromatography imaging system

An imaging system and fluorescence tomography technology, applied in medical science, sensors, diagnostic recording/measurement, etc., can solve the problems of poor resolution and specificity of DOT imaging, and achieve the effect of eliminating differences, effective matching, and large dynamic range.

Active Publication Date: 2013-07-10
TIANJIN UNIV
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Problems solved by technology

However, the endogenous optical contrast between tumor and normal tissue is in the same order of magnitude as that between anatomical structures, resulting in poor resolution and specificity of DOT imaging, and the use of external contrast enhancement is the solution to the above difficulties an efficient way

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  • Calibration method for multi-passage time domain fluorescence chromatography imaging system
  • Calibration method for multi-passage time domain fluorescence chromatography imaging system
  • Calibration method for multi-passage time domain fluorescence chromatography imaging system

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Embodiment Construction

[0046] The present invention will be described below in conjunction with the accompanying drawings and embodiments.

[0047] The present invention for figure 1 In the shown multi-channel time-domain fluorescence breast tomography system, the attenuation rate of all the neutral filters in the N filters at a wavelength of 780nm and the transmittance of the 830nm long-pass filter are calibrated, and the specific implementation The scheme is as follows:

[0048] In calibration, the frequency and intensity of the laser can be set according to the actual measurement needs. For example, set the frequency of the two wavelength lasers to be 20MHz, and the laser intensity to be 23%. The calibration device used to calibrate the attenuation rate of all neutral filters and the transmittance of 830nm long-pass filter in the multi-channel fluorescence breast tomography system is as follows: figure 2 shown. The material of the calibration device is plexiglass as a transparent medium. It ...

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Abstract

The invention belongs to the technical field of tissue optical measurement and relates to a calibration method for a time domain fluorescence chromatography imaging system. The method is used for calibrating transmission factors of each passage of a system and comprises the following steps that: a calibration device used for replacing an imaging cavity in an imaging system is built; a source optical fiber and a detection optical fiber are respectively inserted onto the imaging cavity; some pieces of lens paper are placed into an insertion groove, and the detection optical fiber is connected with the first passage; a 780nm laser is opened, and the attenuation rate of all neutral filters arranged on a filter wheel corresponding to the passage is calibrated; the 780nm laser is turned off, an830nm laser is turned on, and the transmission rate of 830nm long pass filters arranged on a filter wheel corresponding to the passage is calibrated; and the steps are repeated, and the calibration of the relative attenuation rate of all neutral filters arranged on the filter wheel on each passage and the transmission rate of the 830nm long pass filters is completed. The differences on the systempassage transmission performance can be eliminated.

Description

technical field [0001] The invention belongs to the technical field of tissue optical measurement, and in particular relates to a method for calibrating a time-domain fluorescence tomography system. Background technique [0002] Diffuse Optical Tomography (DOT) technology has become a hot research field of molecular imaging because of a series of important indicators such as high specificity, high sensitivity, real-time and safety. The pathological basis of optical breast tomography comes from the "angiogenesis" effect of tumor growth, and the changes in tissue hemodynamics caused by this effect can be sensitively reflected in the changes in optical parameters of the tumor site. However, the endogenous optical contrast between tumor and normal tissue is in the same order of magnitude as that between anatomical structures, resulting in poor resolution and specificity of DOT imaging, and the use of external contrast enhancement is the solution to the above difficulties an eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00
Inventor 高峰武林会张伟卢奕名陈玮婷赵会娟
Owner TIANJIN UNIV
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