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Gastrointestinal motility promoting medicinal oral disintegrating tablets and preparation method thereof

A technology for oral disintegrating tablets and gastrointestinal motility, which is used in pharmaceutical formulations, drug combinations, and medical preparations with inactive ingredients, etc., and can solve the problems of slow disintegration of preparations, affecting the patient's taste and compliance, and having a gritty feeling.

Inactive Publication Date: 2012-07-04
QUANTUM HI TECH BEIJING RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In China, the preparation technology of orally disintegrating tablets started relatively late. At present, the direct compression method is mostly used to prepare orally disintegrating tablets. Most disintegrants are insoluble in water, so the orally disintegrating tablets prepared by this method often have a gritty feeling after tasting, which affects the taste and compliance of patients when taking it; and the disintegration of the preparation will be very slow

Method used

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  • Gastrointestinal motility promoting medicinal oral disintegrating tablets and preparation method thereof
  • Gastrointestinal motility promoting medicinal oral disintegrating tablets and preparation method thereof
  • Gastrointestinal motility promoting medicinal oral disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0154] The preparation formula of the present invention is made up of following components:

[0155] Domperidone 10.00g

[0156] Glycine 4.00g

[0157] Pullulan 4.40g

[0158] Xanthan gum 0.10g

[0159] Sucralose 0.10g

[0160] Mint essence 0.20g

[0161] Purified water 181.20g

[0162] A total of 1000 pieces were made.

[0163] The specific preparation method is as follows: add domperidone, glycine, pullulan, sucralose, and peppermint essence into the fully dissolved xanthan gum solution, and mix to form a uniform solution; after degassing the solution, accurately Pour into the mold; pre-freeze at -40°C to -170°C for 1 to 60 minutes, then transfer to a freeze dryer, and freeze dry for 1 to 10 hours at a pressure of 0.01mbar to 10mbar and at a temperature of -30°C to 30°C , that is, to obtain the orally disintegrating domperidone tablet of the present invention; in the above method, after the pre-freezing step, an ice crystal incubation step can also be added before bei...

Embodiment 2

[0165] The preparation formula of the present invention is made up of following components:

[0166] Domperidone 10.00g

[0167] Mannitol 4.00g

[0168] Pullulan 4.40g

[0169] Xanthan gum 0.10g

[0170] Sucralose 0.10g

[0171] Mint essence 0.20g

[0172] Purified water 181.20g

[0173] A total of 1000 pieces were made.

[0174] The specific preparation method is as follows: Domperidone, mannitol, pullulan, sucralose, and peppermint essence are added to the fully dissolved xanthan gum solution, and mixed to form a homogeneous solution; the following preparation method is the same as in Example 1 .

Embodiment 3

[0176] The preparation formula of the present invention is made up of following components:

[0177] Domperidone 10.00g

[0178] Glycine 2.00g

[0179] Mannitol 2.40g

[0180] Pullulan 2.80g

[0181] Sodium alginate 2.00g

[0182] Konjac Gum 0.60g

[0183] Acesulfame K 0.20g

[0184] Mint essence 0.20g

[0185] Purified water 179.80g

[0186] A total of 1000 pieces were made.

[0187] The specific preparation method is as follows: Domperidone, glycine, mannitol, pullulan, sodium alginate, acesulfame potassium, and peppermint essence are added to the fully dissolved konjac gum solution, and mixed to form a homogeneous solution; the following preparation Method is with embodiment 1.

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Abstract

The invention discloses gastrointestinal motility promoting medicinal oral disintegrating tablets and a preparation method thereof, and relates to gastrointestinal motility promoting medicinal oral disintegrating tablets and a formulation and a technology for preparing the gastrointestinal motility promoting medicinal oral disintegrating tablets by adopting a freeze drying method. The gastrointestinal motility promoting medicinal oral disintegrating tablets are prepared from main medicaments and medicinal auxiliary materials, have good mouthfeel, do not have grit feeling, and greatly improve the medication compliance of patients; the tablets do not require water during administration, can be quickly disintegrated after the tablets enter the mouth, do not cause vomiting reflex, and provide great convenience for the patients; the tablets are suitable to be taken in journey under the condition that a water source is not easily obtained; the tablets have the advantages of convenience in administration, quick absorption, low first pass effect, low irritation to digestive tract mucosa and the like, and have a broad market application prospect; and the gastrointestinal motility promoting medicinal oral disintegrating tablets can obviously reduce the side effects of a gastrointestinal motility promoting medicament. In addition, the invention also relates to the preparation method for the gastrointestinal motility promoting medicinal oral disintegrating tablets.

Description

Technical field: [0001] The invention relates to an orally disintegrating tablet of a drug for promoting gastrointestinal motility and a preparation method thereof, in particular to an orally disintegrating tablet of a drug for promoting gastrointestinal motility prepared by a freeze-drying method. Background technique: [0002] Factors such as the accelerated pace of life in modern society and changes in diet structure have led to an increasing number of patients with hypogastric motility in my country. Decreased gastric motility often leads to functional dyspepsia, gastroesophageal reflux and other diseases, which greatly affects people's quality of life, and many people even face the threat of cancer. Relevant data show that the total number of gastrointestinal diseases in my country is about 300 million, ranking first in the world. According to the survey of domestic epidemiologists, about 50% of outpatients in gastrointestinal specialist clinics are related to gastric ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/36A61K45/00A61K31/454A61P1/14
Inventor 王丛威王洪飞赵淑欣王丽滨周立运
Owner QUANTUM HI TECH BEIJING RES INST