Oil-in-water compound fluconazole nano-emulsion and preparation method thereof
A fluconazole nanometer, oil-in-water type technology, applied in the field of medicine, can solve the problems of difficult body absorption, low drug loading in aqueous solution, and low bioavailability, so as to improve bioavailability, increase drug loading, The effect of improving solubility
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Embodiment 1
[0049] Example 1 A kind of oil-in-water type compound fluconazole nanoemulsion drug, the quality of each component:
[0050] RH-40 25.00g, ethanol 10.00g, butyl acetate 15.00g, fluconazole 1.00g, magnolol 0.35g, distilled water 48.65g.
[0051] Above-mentioned each component is made compound recipe fluconazole nanoemulsion medicine, comprises the following steps:
[0052] 1) Add the above amount of fluconazole into the oil to make it fully dissolved, as the oil phase;
[0053] 2) Mix the amount of magnolol with the co-surfactant to fully dissolve it;
[0054] 3 adding the amount of surfactant and co-surfactant into the oil phase and mixing;
[0055] 4) Use distilled water as the water phase, stir the oil phase quickly at room temperature, slowly add the water phase dropwise while stirring, and keep stirring until the system becomes a transparent liquid, and the oil-in-water compound fluconazole nanoemulsion is obtained.
Embodiment 2
[0056] Example 2 A kind of oil-in-water type compound fluconazole nanoemulsion drug, the quality of each component:
[0057] Tween-80 35.00g, polyethylene glycol 600 3.00, ethanol 2.00g, ethyl acetate 3.00g, fluconazole 0.05g, magnolol 0.70g, distilled water 56.25g.
Embodiment 3
[0058] Example 3 A kind of oil-in-water type compound fluconazole nanoemulsion drug, the quality of each component:
[0059] 40.00 g of RH-40, 1.80 g of ethanol, 2.00 g of 1,2-propanediol, 15.00 g of carvacrol, 2.50 g of fluconazole, 0.01 g of magnolol, and 38.69 g of distilled water.
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