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Fospropofol disodium and alfentanil pharmaceutical composition and application thereof

A technology of fospropofol sodium and composition, applied in the directions of drug combination, antipyretic, pharmaceutical formula, etc., can solve the problems of weak analgesic effect, short duration, poor stability and the like, and achieve good analgesia and good water solubility. Sex, the effect of reducing the number of doses

Inactive Publication Date: 2012-07-18
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Propofol is a short-acting phenolic alkanes drug with quick onset, short duration, quick and stable recovery, but weak analgesic effect and insoluble in water. It is clinically used as an emulsion with poor stability

Method used

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  • Fospropofol disodium and alfentanil pharmaceutical composition and application thereof
  • Fospropofol disodium and alfentanil pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] According to the commonly used doses of alfentanil and fospropofol sodium and related experiments, the formula of the compound preparation is determined as:

[0021] Alfentanil 5mg

[0022] Fospropofol Sodium 2500mg

[0023] Sodium chloride 9mg

[0024] Add water for injection to 10ml

[0025] Add an appropriate amount of 0.1mol / L hydrochloric acid to adjust the pH value to 6.0-7.0, mix well, and bottle (2ml per bottle)

[0026] The preparation method of the present invention comprises the following steps: add a small amount of sterilized water for injection into the liquid preparation container, add sodium chloride and alfentanil and fospropofol sodium in accurate prescription quantities, stir to dissolve, and slowly add pH regulators such as hydrochloric acid, sodium dihydrogen phosphate, etc., adjust the pH range to 6.0-7.0, add water to the full amount, then add 0.01%-1.0% (W / V) medicinal charcoal, stir for 30-60min, sand Decarburize the filter rod by coarse fil...

Embodiment 2

[0028] Alfentanil 5mg

[0029] Fospropofol Sodium 3000mg

[0030] Sodium chloride 9mg

[0031] Add water for injection to 10ml

[0032] The preparation method is the same as in Example 1.

Embodiment 3

[0034] Alfentanil 5mg

[0035] Fospropofol Sodium 1250mg

[0036] Glucose 40mg

[0037] Add water for injection to 10ml

[0038] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a pharmaceutical composition having abirritation and sedation, which comprises alfentanil and fospropofol disodium, wherein the weight ratio of alfentanil and fospropofol disodium is 1: (100 to 2500). The pharmaceutical composition is used in a form of a conventional medicine preparation, and a preferential medicament form is injection. By combining narcotic analgesic and narcotic sedative, better abirritation and better sedation can be realized, and times for applying medicine can be reduced, so that the anesthesia induction process is more convenient.

Description

technical field [0001] The invention relates to a compound medicine, in particular to a compound medicine of fospropofol sodium and alfentanil, and belongs to the technical field of medicine. Background technique [0002] At present, anesthesia and sedative anesthesia are used simultaneously for induction of anesthesia in surgery. In clinical practice, anesthesia and analgesics such as fentanyl and anesthesia and sedative propofol are often combined. Alfentanil (alfentanil) is an ultra-short-acting opioid drug with fast onset, fast disappearance, strong analgesic effect, little effect on the cardiovascular system, but extremely weak sedative effect. Adverse reactions include cardiovascular depression, opioid central nervous system effects, respiratory depression, etc. Propofol is a short-acting phenolic alkanes drug with quick onset, short duration, rapid and stable recovery, but weak analgesic effect and insoluble in water. It is clinically used in the form of emulsion wit...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/454A61P29/00A61P25/20
Inventor 熊利泽文爱东贾娜关月王超
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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