Kasugamycin hydrochloride soluble granules and preparation method of the granules

Abstract

The invention relates to kasugamycin hydrochloride soluble granules. The kasugamycin hydrochloride soluble granules comprise the following raw materials by weight: 4-20% of kasugamycin hydrochloride, 2-5% of a wetting agent, 4-20% of a dispersing agent, 1-10% of a binder and 50-80% of a filler. The preparation method of the kasugamycin hydrochloride soluble granules comprises the following steps: uniformly mixing the raw materials proportionally; grinding the raw materials to be 1.5-3mum through a wet method or a dry method; and pelletizing by way of extrusion, fluidized bed or spray-drying, screening and taking granules with sizes of 0.27mm to 1.7mm as qualified products. The kasugamycin hydrochloride soluble granules and the preparation method have the beneficial effects that the utilization rate of effective components is increased; almost no harms are posed on the environment, people, livestock and other beneficial organisms; dust is avoided in production process, granule disintegrating speed is fast and package pollution is avoided; and the advantages of good storage stability, simplicity in process, convenience in use and suitability for large-area popularization and application are gained.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to a pesticide kasugamycin hydrochloride soluble granule and a preparation method thereof. Background technique [0002] Traditional formulations of pesticides such as emulsifiable concentrates, powders and wettable powders account for 80% of my country's formulation output, and other commonly used formulations include aqueous emulsions, microemulsions, and suspensions. With the development of society, people pay more and more attention to environmental protection, cleanliness, etc., so the shortcomings of traditional dosage forms are becoming more and more prominent. The emulsifiable concentrate contains a large amount of organic solvents such as xylene and toluene, which not only cause serious pollution to the environment, but also cause waste of petrochemical resources. The main problem of powder is dust drift, which is only used in arid areas and some specific places. Due t...

AI Technical Summary

Problems solved by technology

Water-emulsion and microemulsion are two popular environmental-friendly dosage forms, but they both have the same problems: the decomposition of active ingredients of pesticides and the instability of solutions

However, due to the late appearance of soluble granules, in order to make full use of and enhance the advantages of this dosage form, there are still many areas that need to be improved in the types and dosages of various excipients, as well as the preparation methods.