Anti-CD4 protein monoclonal antibody and its active fragment and application

A monoclonal antibody and protein technology, applied in the fields of prevention, immunotherapy and diagnosis, can solve problems such as interference
CN102649818BActive Publication Date: 2014-10-08XIAMEN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2014-10-08

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Abstract

Provided are an anti-CD4 protein monoclonal antibody, active fragments and uses thereof. The antibody of the present invention can block the binding of the human immunodeficiency virus and human CD4 protein for invasion into cells. The antibody of the present invention can be used for detecting, diagnosing, preventing and treating diseases of which target cells are CD4 cells, especially AIDS caused by the human immunodeficiency virus (HIV). Further provided are corresponding hybridoma cell lines, isolated nucleic acids molecule and oligopeptides, as well as pharmaceutical compositions and kits comprising the monoclonal antibody.
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Description

field of invention

[0001] The present invention relates to a monoclonal antibody that can specifically bind to a human surface antigen differentiation cluster 4 (Cluster of Differentiation 4, CD4) protein, a conservative variant or an active fragment thereof, and a related coding sequence of a polypeptide or a polypeptide analog thereof, to produce the Cell lines of monoclonal antibodies, and methods and uses of the antibodies or fragments for prevention, immunotherapy and diagnosis; prevention or treatment of primates, including humans, whose source of infection is CD4 + Diseases caused by the main target cells of cells: These diseases include acquired immunodeficiency syndrome (AIDS, AIDS), AIDS-related diseases, and human immunodeficiency virus (human immunodeficiency virus, HIV) infection. Background technique

[0002] Since the discovery of HIV in the last century, many researchers have devoted themselves to research on HIV molecular biology, immunity, and vaccines. How...

Claims

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