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Palonosetron oral cavity membrane preparation and preparation method thereof

A technology of palonosetron and oral film, which is applied in the field of biomedicine to achieve the effects of complete dissolution and absorption, simple production process, and good taste

Inactive Publication Date: 2012-09-05
FOSHAN DAYI TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the various problems existing in the current dosage form of palonosetron as a medicine for treating vomiting, and provides a kind of palonosetron oral film and its preparation method to solve the above problems

Method used

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  • Palonosetron oral cavity membrane preparation and preparation method thereof
  • Palonosetron oral cavity membrane preparation and preparation method thereof
  • Palonosetron oral cavity membrane preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The palonosetron oral film composition of the present embodiment is as follows:

[0023]

[0024]

[0025] Preparation method: (1) soak polyvinyl alcohol in an appropriate amount of purified water, and dissolve it in a water bath at 80-90°C after swelling; (2) soak and dissolve agar in purified water, add palonosetron and stir evenly, and then add carboxylate Methyl starch, mannitol; (3) After mixing the above two liquids, add glycerin and stevioside, add purified water to a sufficient amount, remove air bubbles, apply a film, dry and divide into 1.0mg palonosetron containing each The diaphragm of the film is packaged after being sterilized by ultraviolet light.

Embodiment 2

[0027] The palonosetron oral film composition of the present embodiment is as follows:

[0028]

[0029] Preparation method: (1) Soak polyvinyl alcohol in an appropriate amount of purified water, and dissolve it in a water bath at 80-90°C after swelling; (2) Soak and dissolve gum arabic in purified water, add palonosetron and stir evenly, and then add Calcium hydrogen phosphate; (3) After mixing the above two liquids, add glycerin, mint, stevioside, add purified water to a sufficient amount, remove air bubbles, apply a film, dry and divide into tablets containing Palonosetron 2.0mg The film is packaged after ultraviolet sterilization.

Embodiment 3

[0031] The palonosetron oral film composition of the present embodiment is as follows:

[0032]

[0033] Preparation method: (1) Soak polyvinyl alcohol in an appropriate amount of purified water, and dissolve it in a water bath at 80-90°C after swelling; (2) Soak and dissolve gelatin in purified water, add palonosetron and stir evenly, and then add starch (3) After mixing the above two liquids, add glycerin, peppermint, stevioside, add purified water to a sufficient amount, remove air bubbles, apply a film, dry and divide into diaphragms containing 1.5 mg of palonosetron , packaged after ultraviolet sterilization.

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Abstract

The invention relates to the technical field of biological medicine, in particular to a palonosetron oral cavity membrane preparation and a preparation method thereof. The palonosetron oral cavity membrane preparation and the preparation method thereof have the following advantages: (1) the oral cavity membrane preparation overcomes the bitter taste of palonosetron, has a good mouthfeel, and is completely dissolved and absorbed so that a patient can easily accept the palonosetron, and the oral cavity membrane preparation can be taken in any occasion without water, and is particularly suitable for patients who undergo chemotherapy and possibly vomit if drinking water; (2) the palonosetron oral cavity membrane preparation can quickly release a medicine and has the characteristics of quick effect acting and quick release; and (3) the palonosetron oral cavity membrane preparation is simple in production process and low in cost and is convenient to carry.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a palonosetron oral film and a preparation method thereof. Background technique [0002] Nausea and vomiting of varying degrees almost always occur in cancer chemotherapy, for example, the incidence rate of cisplatin therapy exceeds 99%. Chemotherapy-induced nausea and vomiting (CINV) is one of the top three factors that make patients fear chemotherapy, which seriously affects the quality of life, treatment compliance and efficacy of patients. Therefore, the development of chemotherapy adjuvant drugs has played a vital role in improving the efficacy of chemotherapy and reducing adverse reactions. [0003] The 5-HT3 receptor in the human body participates in the vomiting reflex, and the vomiting caused by the excitement is especially sensitive to cancer chemotherapy stimulation. Since cisplatin and other drugs enter the blood vessels, its metabolite 5-hydroxyindoleacetic acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/473A61P1/08
Inventor 阴元魁雍智全闻亚磊陈宝林唐良伟庄东杰
Owner FOSHAN DAYI TECH LTD
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