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Azithromycin granules and preparation method thereof

A technology of azithromycin and granules, which is applied in the field of chemical pharmacy, can solve the problems that the bitter taste of medicine cannot be effectively masked, and the patient's medication compliance is poor, and achieves the effects of low production cost, high production efficiency and improved taste.

Inactive Publication Date: 2012-09-12
SICHUAN BAILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the extremely bitter taste of azithromycin, although the prepared granules are added with flavoring sweeteners, they still cannot effectively cover the bitter taste of the drug, making patients, especially children, poorly compliant with the drug.

Method used

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  • Azithromycin granules and preparation method thereof

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Effect test

Embodiment 1

[0033] Embodiment 1: A kind of azithromycin granule (specification 0.1g), its prescription is as follows:

[0034] Azithromycin 100g

[0035] Trisodium Phosphate 20g

[0036] Hydroxypropyl Methyl Cellulose 5g

[0037] Acesulfame K 10g

[0038] Sweet Orange Flavor 10g

[0039] Sucrose 855g

[0040] Appropriate amount of pure water.

[0041] Make 1000 bags.

[0042] Preparation:

[0043] (1) Azithromycin, trisodium phosphate, acesulfame potassium, and sucrose in the prescription were crushed separately and passed through a 100-mesh sieve;

[0044] (2) Hydroxypropyl methylcellulose and aromatics are directly passed through a 100-mesh sieve.

[0045] (3) Weigh the raw and auxiliary materials of the prescribed amount, dry mix them in a mixer for 10 minutes, mix them evenly, use pure water as a wetting agent, granulate with a 16-mesh screen, dry the granules at 55°C for about 3 hours, and granulate , Sieve the particles between 10-60 meshes, and pack them separately.

Embodiment 2

[0046] Embodiment 2: a kind of azithromycin granule (specification 0.125g), its prescription is as follows:

[0047] Azithromycin 125g

[0048] Trisodium Phosphate 20g

[0049] Hydroxypropyl Methyl Cellulose 5g

[0050] Acesulfame K 10g

[0051] Sweet Orange Flavor 10g

[0052] Sucrose 830g

[0053] Appropriate amount of pure water.

[0054] Make 1000 bags.

[0055] Preparation:

[0056] (1) Azithromycin, trisodium phosphate, acesulfame potassium, and sucrose in the prescription were crushed separately and passed through a 100-mesh sieve;

[0057] (2) Hydroxypropyl methylcellulose and aromatics are directly passed through a 100-mesh sieve.

[0058] (3) Weigh the raw and auxiliary materials of the prescribed amount, dry mix them in a mixer for 10 minutes, mix them evenly, use pure water as a wetting agent, granulate with a 16-mesh screen, dry the granules at 55°C for about 3 hours, and granulate , Sieve the particles between 10-60 meshes, and pack them separately.

[...

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Abstract

The invention discloses azithromycin granules, which consist of the following components in parts by weight: 5-20 parts of azithromycin, 1.5-3.0 parts of sodium triphosphate, 0.4-0.6 parts of hydroxypropyl methyl cellulose, 0.8-1.2 parts of acesulfame, 0.8-1.2 parts of sweet orange taste essence, 80-95 parts of sugar and a proper amount of pure water. The invention also discloses a preparation method of the azithromycin granules. The conception is skilful, the mouthfeel of the medicament is effectively improved through a simple medicinal composition, an unexpected effect of covering the bitterness of the medicament is achieved, and dissolution of the medicament in vivo is not influenced. The preparation method has the advantages of simple process, no need of special equipment and low production cost.

Description

technical field [0001] The invention belongs to the technical field of chemical pharmacy, and relates to azithromycin granules and a preparation method thereof. Background technique [0002] Azithromycin (Azithromycin), originally developed by SourPliva in Yugoslavia, was the first to be marketed in the country. Pfizer of the United States, after acquiring the global development rights, pushed it to the global market. The product was launched in the UK in September 1990, and was approved by the FDA in the United States at the end of 1991. Azithromycin is a macrolide antibiotic developed and produced in recent years. It is a broad-spectrum antibiotic obtained by modifying the chemical structure of erythromycin. It is suitable for respiratory tract, skin and soft tissue infections caused by sensitive bacteria, and transmission caused by chlamydia. disease. Azithromycin inhibits the synthesis of bacterial proteins by hindering the process of bacterial transpeptidation. Its me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7052A61K47/38A61P31/04
Inventor 王一茜龚涛杜书良廖彬
Owner SICHUAN BAILI PHARM CO LTD
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