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Nifuroxazide microcapsule powder and production method thereof

The technology of nifuryl hydrazide microcapsule powder and nifuryl hydrazide is applied in the field of veterinary drug manufacture and animal feed additives, and can solve the problems of application effect and expansion of application scope restriction, low dissolution rate, influence on drug effect and the like, To achieve the effect of favorable absorption and medication effect, adsorption and uniformity improvement, and good feeding effect

Active Publication Date: 2012-09-12
SHANGHAI E K M BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the market mainly supplies the market demand with raw materials and powder formulations with a content of 20%. Due to the low water solubility of this product, the bioavailability is low, which affects the full play of the drug effect.
At present, there are no more products that are more convenient to use and can improve the application effect more effectively, so the improvement of the application effect of the product and the expansion of the application range have been restricted. Furthermore, the current commercially available products generally have low water solubility and dissolution Problems such as low concentration, precipitation and darkening of color often occur during the application process, which directly affect the effect of medication
[0004] Aiming at the deficiencies of the above-mentioned technologies, the present invention provides a production method of nifurofen hydrazide microcapsule powder, and the prepared microcapsule powder effectively overcomes the deficiencies of poor water solubility and low dissolution rate of nifurofarzide, and can effectively Improve the dissolution rate and solubility of the drug, and improve the stability of the drug
After searching, no literature reports or patent applications related to the preparation of nifurofen hydrazide microcapsule powder were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Get 1 kg of nifurofurol hydrazide and pulverize it, and cross a 600 mesh sieve to get nifurofarzide fine powder for subsequent use; get 0.01 kg of cyclamate and dissolve it with 2 kg of 95% ethanol to make cyclamate in ethanol; Put the above nifurofarzide fine powder in a blender, add ethanol solution of cyclohexanesulfonic acid, stir evenly, then add 2kg of 1000 mesh silicon dioxide micropowder, after fully stirring evenly, pass through a 200 mesh sieve to make a capsule core; Put the capsule core into a stainless steel interlayer pot with a stirring device, add 4kg of polyethylene glycol 4000 and stir evenly, heat the interlayer at 75°C to 80°C, melt it and stir it evenly, then immediately pour it into a metal plate in an ice-water bath , make it cool and solidify rapidly, put it into a desiccator to dry for 24 hours, and use a jet mill to make a powder with a particle size of 90 to 100 meshes to obtain the finished nifurofarzide microcapsule powder.

Embodiment 2

[0025] Get 1 kg of nifurofurol hydrazide and pulverize it, and cross a 600 mesh sieve to get nifurofarzide fine powder for subsequent use; get 0.015 kg of cyclamate and dissolve it with 2 kg of 95% ethanol to make cyclamate ethanol solution; Put the above nifurofarzide fine powder in a blender, add ethanol solution of cyclamate, stir evenly, then add 1 kg of 1000 mesh silicon dioxide micropowder, stir well, pass through a 200 mesh sieve to make a capsule core; Put the capsule core into a stainless steel interlayer pot with a stirring device, add 3kg of polyethylene glycol 6000 and stir evenly, heat the interlayer at 75°C to 80°C to melt and stir evenly, then immediately pour it into a metal plate in an ice-water bath , make it cool and solidify rapidly, put it into a desiccator to dry for 24 hours, and use a jet mill to make a powder with a particle size of 90 to 100 meshes to obtain the finished nifurofarzide microcapsule powder.

Embodiment 3

[0027] Get 1 kg of nifurofurol hydrazide and pulverize it, and cross a 600 mesh sieve to get nifurofarzide fine powder for subsequent use; get 0.02 kg of cyclamic acid and dissolve it with 2 kg of 95% ethanol to make cyclamic acid ethanol solution; Put the above nifurofarzide fine powder in a blender, add ethanol solution of cyclamate, stir evenly, then add 3kg1100 mesh silicon dioxide micropowder, after fully stirring evenly, pass through a 200 mesh sieve to make the capsule core; Put the capsule core into a stainless steel interlayer pot with a stirring device, add 6kg of polyethylene glycol 6000 and stir evenly, heat the interlayer at 75°C to 80°C, melt it and stir it evenly, then immediately pour it into a metal plate in an ice-water bath , make it cool and solidify rapidly, put it into a desiccator to dry for 24 hours, and use a jet mill to make a powder with a particle size of 90 to 100 meshes to obtain the finished nifurofarzide microcapsule powder.

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Abstract

The invention discloses nifuroxazide microcapsule powder and a production method thereof. The nifuroxazide microcapsule powder is characterized by consisting of nifuroxazide, n-cyclohexylsulphamic acid, silicon dioxide micro powder and polyethylene glycol in a weight ratio of 1: (0.01-0.02): (1-3): (3-6). The production method comprises the following steps of: dissolving the n-cyclohexylsulphamicacid by using 95 percent ethanol, stirring with fine nifuroxazide powder to wet the fine nifuroxazide powder uniformly, adding the silicon dioxide micro powder to form a core material, mixing the core material and the polyethylene glycol 4000 or polyethylene glycol 6000 uniformly, performing interlayer heating at the temperature of between 75 and 80 DEG C to melt the mixture, cooling, curing, drying, crushing with airflow to form powder with the particle diameter of 90 to 100 meshes, and thus obtaining the nifuroxazide microcapsule powder. The nifuroxazide microcapsule powder is low in heat loss rate and high in flowability, has a good feeding effect, and facilitates industrialized production.

Description

technical field [0001] The invention relates to the technical field of feed additives for animals, and also to the field of veterinary drug manufacturing, in particular to a nifurofen hydrazide microcapsule powder and a production method thereof. Background technique [0002] Nifuroxazide, whose chemical name is 4-hydroxy-2 ‘ -(5-Nitrofuryl methylene)-benzohydrazide, yellow or bright yellow powder, usually hardly or slightly soluble in water. Nifurofen hydrazide has a broad antibacterial spectrum, high antibacterial activity, and low inhibitory concentration. It has no cross-resistance with sulfonamides, quinolones and other antibiotics. Its antibacterial activity is hardly affected by other organic substances, and its effect is stable. Because the product can effectively prevent intestinal or urinary system diseases caused by Escherichia coli, Salmonella, Pasteurella (including Listeria), Aerobacter, Proteus, Necroptosis and Staphylococcus in livestock and poultry, and can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/345A61K47/34A61K47/04A61P31/04A23K1/17A23K20/195
Inventor 张奎昌张婷婷张路
Owner SHANGHAI E K M BIOTECH
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