Separation and purification process of tetrahydroxy stilbeneglycoside

A tetrahydroxy stilbene, separation and purification technology, applied in organic chemistry, chemical instruments and methods, preparation of sugar derivatives, etc., can solve the problems of large sample loss, low recovery rate, unstable separation and purification, etc., to simplify separation Purification steps, overall process conditions are mild, soluble and stable
CN102659863AInactive Publication Date: 2012-09-12FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FOURTH MILITARY MEDICAL UNIVERSITY
Publication Date
2012-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a separation and purification process for extracting tetrahydroxy stilbeneglycoside from roots and stems of Polygonum multiflorum. The process comprises the following steps of: firstly, extracting the Polygonum multiflorum by ethanol to obtain a leaching solution; removing an ethanol solvent to obtain a brown extract; adding ethyl ether into the brown extract to carry out cold soaking treatment and removing an ether layer; adding water into an extract obtained by the cold soaking treatment to dissolve; utilizing ethyl acetate to extract and collect an ester layer; removing a solvent to obtain a brown crude product; adding alkali liquid into the crude product to adjust a pH (Potential of Hydrogen) to 8-10; then utilizing the ethyl acetate to extract; adding cyclohexane and ethanol into an extracted water layer; carrying out rotary evaporation to remove the solvent to obtain a TSG (TetrahydroxyStilbene Glucoside) salt crude product; and acidifying and extracting by the ethyl acetate to obtain a pure product. According to the separation and purification process disclosed by the invention, various complicated column chromatographs are avoided and a synthesis process is greatly simplified; and whole process conditions are moderate, and a toxic and harmful solvent is not used, so that the separation and purification process is suitable for industrial production.
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Description

technical field

[0001] The invention relates to a separation and purification process for extracting stilbene glycoside monomers from the rhizomes of Polygonum multiflorum, belonging to the technical field of separation and extraction of natural products. Background technique

[0002] Vascular dementia (VD) refers to a group of advanced neurocognitive dysfunctions based on brain tissue damage caused by ischemic, hemorrhagic, and acute and chronic ischemic-hypoxic cerebrovascular diseases. It is the second leading cause of dementia after Alzheimer's disease. Its clinical manifestations include memory impairment, cognitive impairment, personality changes, loss of orientation, abnormal behavior, and low daily social and living abilities. According to the epidemiological survey, VD accounts for about 20% of senile dementia in European and American countries, and about 60% in my country; the prevalence rate of VD in Japan reaches 1.1%-3.0%. With the acceleration of the aging pr...

Claims

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