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Percutaneous absorption preparation for treating bone joint disease

A technology for transdermal absorption preparations and bone and joint diseases, applied in the field of pharmaceutical preparations, can solve problems such as poor transdermal absorption, and achieve rapid onset and obvious therapeutic effects

Inactive Publication Date: 2012-09-19
山东卫康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The transdermal absorption preparation of the present invention delivers active ingredients such as glucosamine to bone and joint sites in a rapid and high amount, which solves the problem of poor transdermal absorption of existing preparations, thereby realizing the local synergistic treatment of bone and joint diseases with various active ingredients good curative effect

Method used

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  • Percutaneous absorption preparation for treating bone joint disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0018] The preparation of embodiment 1-5 transdermal absorption cream

[0019] Prescription composition:

[0020] Table 1 Embodiment 1-5 transdermal absorption cream prescription (by weight)

[0021] components Example 1 Example 2 Example 3 Example 4 Example 5 Glucosamine Hydrochloride 7.2 7.0 5.0 5.5 6.0 Sea cucumber freeze-dried powder 11.2 10.5 8.0 10.0 6.5 Menthol 7.0 8.1 5.0 6.0 6.0 ice flakes 4.2 3.8 3.0 4.0 4.0 clove oil 5.6 6.0 4.0 4.8 5.0 stearic acid - 1.0 1.5 1.2 1.8 Glyceryl monostearate - - 1.5 2.0 1.8 cetostearyl alcohol - - 4.0 3.8 4.5 Tween 60 - 3.2 4.0 5.0 5.0 Isopropyl palmitate - - 4.0 3.2 3.5 white oil - - 6.0 5.5 5.8 glycerin - 6.0 8.0 10.0 10.0 Jamie (preservative) Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount deionized water 64.4 54.2 46.0 40.0 ...

Embodiment 6

[0026] Example 6 Study on anti-inflammatory immune effect of the transdermal absorption cream of the present invention on rats with rheumatoid arthritis

[0027] Preparation of blank transdermal absorption cream (by weight):

[0028] (1) Prepare the oil phase component solution: ① 1.5 parts of stearic acid, ② 1.5 parts of glyceryl monostearate, ③ 4 parts of cetostearyl alcohol, ④ 4 parts of Tween 60, ⑤ 4 parts of isopropyl palmitate , ⑥ 6 parts of white oil, ⑦ 5 parts of menthol, ⑧ 3 parts of borneol, ⑨ 4 parts of clove oil;

[0029] (2) Preparation of aqueous component solution: ① 5 parts of glucosamine hydrochloride, ② 8 parts of 800-1000 mesh sea cucumber freeze-dried powder, ③ 8 parts of glycerin, ④ 46 parts of deionized water, ⑤ appropriate amount of Jiemei (preservative);

[0030] (3) Weigh the various components in the water phase and the oil phase according to the formula requirements, and then heat the water phase and the oil phase to 85-90°C in two containers resp...

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Abstract

The invention discloses a percutaneous absorption preparation for treating a bone joint disease, which relates to the technical field of medical preparations. The percutaneous absorption preparation is prepared from a D-glucosamine hydrochloride, sea cucumber lyophiled powder and medical auxiliary materials according to a specified mixture ratio. Active ingredients in the D-glucosamine hydrochloride and sea cucumber lyophiled powder are used for treating the bone joint disease in a synergetic way, and directly enter blood circulation of bone joint positions quickly at high flux; and the percutaneous absorption preparation has quick response and a good treatment effect, is environment-friendly, acts for a long time and does not cause rebounding.

Description

Technical field [0001] The present invention involves the field of pharmaceutical preparation technology, especially a translucent absorption preparation that treats bone joint diseases. Background technique [0002] Bone and joint diseases are a common type of disease in middle -aged and elderly people, and there is a trend of youth. Bone joint disease is one of the diseases with a very high disability rate. It is a difficult disease.Bone joint disease is a worldwide common problem. According to statistics from the World Health Organization, patients with bone joint diseases are 50%or more people over 50%, 80%of people over 55 years old, and elderly people over 60 years old.Diseases with bone and joint diseases.The total number of patients with bone and joint diseases has exceeded 150 million. Moreover, as my country enters an aging society, the incidence of bone joint disease will increase high year by year.Patients suffering from bone joint disease are suffering from pain and ...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K47/44A61K9/06A61P19/02A61P29/00A61K31/7008A61K35/616
Inventor 张中民苗涛王宗继焦念强
Owner 山东卫康生物医药科技有限公司
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