Process for preparing polysucrose

A process method, the technology of polysucrose, which is applied in the field of compound preparation, can solve the problems of insufficient polysucrose yield and purity, and achieve the effects of short reaction process, less pollution and fewer procedures

Active Publication Date: 2012-09-26
ADANA FOOD TECH LIUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a process for preparing polysucrose, which can prepare polysucrose under milder conditions, and solve the problem that the yield and purity of polysucrose in the prior art are not high enough

Method used

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  • Process for preparing polysucrose
  • Process for preparing polysucrose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Put 80g of sucrose, 24ml (ie 24g) of distilled water, 40g of epibromopropane into a device with a thickness of 2cm on a ceramic membrane loaded with D201 resin, and react at 25°C for 2 hours. The pH of the reaction is 12, and the mixture is Polymerization is carried out on the strongly basic anion exchange resin, the temperature is raised to 60°C, and the reaction is continued for 2 hours, and then the reaction solution is eluted with distilled water, and the product low cross-linked polysucrose is adsorbed on the resin. The product was purified with acetone, and the low cross-linked polysucrose was eluted and graded with absolute ethanol. The selected low cross-linked polysucrose had a weight average molecular weight of 300,000.

[0015] Add 5 g of low cross-linked polysucrose, 20 ml of distilled water, and 3 ml of epibromohydrin to a 250 ml three-necked flask with a stirring device, and stir thoroughly to make it evenly mixed. Add 3ml of Span 85 to 150ml of chlorobenzene...

Embodiment 2

[0017] In a 250 ml three-necked flask with a stirring device, 5 g of the low cross-linked polysucrose prepared in Example 1, 20 ml of distilled water, and 4 ml of epibromohydrin were added, and fully stirred to make them uniform. Add 3 ml of Tween 85 to 150 ml of chlorobenzene into the mixture, and adjust the pH to 13 with aqueous sodium hydroxide. Then reacted in a water bath at 70°C for 1.5 hours, and a large number of microspheres appeared. After curing at 90°C for 9.5 hours, the product was filtered, washed with absolute ethanol and distilled water several times to obtain transparent spherical particles, dried, yield 95.9%, product purity 98.2 %.

Embodiment 3

[0019] In a 250 ml three-necked flask with a stirring device, 5 g of the low cross-linked polysucrose prepared in Example 1, 20 ml of distilled water, and 4 ml of epibromohydrin were added, and fully stirred to make them uniform. Add 4.2ml of Span 85 to 150ml of liquid paraffin into the mixture, and adjust the pH to 12 with aqueous sodium hydroxide. Then reacted in a water bath at 75°C for 1.5 hours, a large number of microspheres appeared, cured at 95°C for 10 hours, the product was filtered, washed with absolute ethanol and distilled water several times to obtain transparent spherical particles, dried, yield 94.6%, product purity 99.2 %.

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Abstract

The invention discloses a process for preparing polysucrose. The process includes following steps: placing sucrose, distilled water and epibromohydrin after mixing into a device loaded with strong-base anion exchange resin; subjecting the mixture to polymerization reaction on the strong-base anion exchange resin at the temperature of 25 DEG C to 30 DEG C, heating to 60 DEG C to 65 DEG C for re-reaction, eluting the product after the reaction with the distilled water, and absorbing low cross-linked polysucrose of the product on the resin; purifying the product with acetone, and subjecting the purified product to graded eluting with anhydrous ethanol and selecting proper low cross-linked polysucrose; mixing the proper low cross-linked polysucrose with the distilled water and the epibromohydrin, dissolving dispersant into oil phase to be added to the mixture, adjusting the pH of the system with sodium hydroxide solution, performing water bath heating reaction, heating and solidifying; and filtering the obtained product and repeatedly washing with the anhydrous ethanol and the distilled water to get transparent polysucrose granule. The process for preparing the polysucrose is simple, easy to implement and higher in reaction activity, so that productivity and purity of the polysucrose are improved.

Description

Technical field [0001] The invention relates to the technical field of compound preparation, in particular to a process method for preparing water-soluble polymers. Background technique [0002] Ficoll is a typical sucrose polymer. It is a water-soluble white powdery polymer with a particle size of about 10 nanometers in solution and can be stored at room temperature. According to its molecular weight, it is further divided into: Ficoll 800, Ficoll 400, Ficoll 200, Ficoll 100, Ficoll 70, Ficoll 10. The endogenous viscosities are: 24.5, 17, 12, 8, 7, 2.5 cp. Ficoll has the characteristics of good biocompatibility, high reactivity, and good water solubility, and is currently mainly used in the field of cell separation. And because of its good performance, it has great application potential in the field of protein adsorption, tissue engineering, and immunology. [0003] The current synthetic methods of sucrose-based polymers are mainly chemical synthesis and enzymatic synthesis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00C08J3/24
Inventor 邱新荣金琼曹慧赟
Owner ADANA FOOD TECH LIUZHOU
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