Method for preparing transparent biological substrate with spectral enhancement function

A spectrum-enhancing, bio-based technology, applied in the field of preparation of transparent bio-substrates, can solve the problems of metal materials being opaque, and achieve the effect of wide range of spectral enhancement conditions, good repeatability, and easy industrialization

Inactive Publication Date: 2014-08-13
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, metal materials are opaque and cannot meet this urgent need.

Method used

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  • Method for preparing transparent biological substrate with spectral enhancement function
  • Method for preparing transparent biological substrate with spectral enhancement function
  • Method for preparing transparent biological substrate with spectral enhancement function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Chemically clean the glass substrate: First, use anhydrous acetone to ultrasonically clean the optical carrier / cover slip (domestic brand - Sailing brand, model 7101) for 10 minutes to remove the grease on the surface of the optical carrier / cover slip and adsorb impurities. All commercially available anhydrous acetones can be used in the present invention, the same below.

[0022] Then put the optical slide / cover slip into the alkaline mixed solution of ammonia, hydrogen peroxide and water and boil for 10 minutes. : 1: 6 preparation, after cooking, rinse off the residual alkaline cleaning solution on the slide / cover slip with deionized water.

[0023] Then put the optical slide / cover slip into the acidic mixed solution of hydrochloric acid, hydrogen peroxide and water and boil for 10 minutes. 1:6 preparation, after cooking, rinse off the residual acidic cleaning solution on the slide / cover slip with deionized water and dry it.

[0024] (2) Deposit indium tin oxid...

Embodiment 2

[0029] (1) Chemically clean the glass substrate: First, use anhydrous acetone to ultrasonically clean the optical carrier / cover slip (domestic brand - Sailing brand, model 7101) for 15 minutes to remove the grease on the surface of the optical carrier / cover slip and adsorb impurities.

[0030] Then put the optical slide / cover slip into the alkaline mixed solution of ammonia, hydrogen peroxide and water and boil for 14 minutes. : 1: 6 preparation, after cooking, rinse off the residual alkaline cleaning solution on the slide / cover slip with deionized water.

[0031] Then put the optical slide / cover slip into the acidic mixed solution of hydrochloric acid, hydrogen peroxide and water and boil for 9 minutes. The acidic mixed solution is composed of 36% hydrochloric acid, 30% hydrogen peroxide and deionized water by volume ratio: 1:6 preparation, after cooking, rinse off the residual acidic cleaning solution on the slide / cover slip with deionized water and dry it.

[0032] (2) Et...

Embodiment 3

[0036] (1) Chemically clean the glass substrate: First, use anhydrous acetone to ultrasonically clean the optical carrier / cover slip (domestic brand - Sailing brand, model 7101) for 8 minutes to remove the grease on the surface of the optical carrier / cover slip and adsorb impurities.

[0037] Then put the optical slide / cover slip into the alkaline mixed solution of ammonia, hydrogen peroxide and water and boil for 15 minutes. : 1: 6 preparation, after cooking, rinse off the residual alkaline cleaning solution on the slide / cover slip with deionized water.

[0038] Then put the optical slide / cover slip into the acidic mixed solution of hydrochloric acid, hydrogen peroxide and water and boil for 15 minutes. 1:6 preparation, after cooking, rinse off the residual acidic cleaning solution on the slide / cover slip with deionized water and dry it.

[0039] (2) Etching step: Etching the surface of the glass substrate: placing the dried optical carrier / cover glass on a heating platform...

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Abstract

The invention discloses a preparation method of a transparent bio-substrate with a spectrum enhancing function, including three steps of cleaning, etching, and depositing an indium tin oxide nano-film on a glass substrate. The invention combines ITO with superior surface plasmon properties The film material is introduced into the ordinary optical slide / cover glass, and a new biological substrate with overall transparency and Raman and fluorescence enhancement functions is obtained. Compared with metal surface plasmon materials that are opaque and prone to oxidation failure, glass-based indium oxide Tin thin film has the advantages of overall high transparency, good thermal stability, and chemical inertness. It can excite and collect Raman / fluorescence spectrum signals from both sides, and greatly enhances the Raman signal of adsorbed trace organic molecular probes. , can also significantly enhance the molecular fluorescence signal.

Description

technical field [0001] The invention belongs to the technical field of spectrum sensing, and specifically relates to a preparation method of a transparent biological substrate with a spectrum enhancing function. Background technique [0002] In 1974, Fleischmann and his collaborators first observed high-quality Raman spectra of a monolayer of pyridine molecules adsorbed on the surface of a rough silver electrode, where the Raman signal intensity of each adsorbed molecule was 6 orders of magnitude higher than that of pyridine molecules in the solution phase . This is a surface-enhancing effect associated with rough surfaces, known as surface-enhanced Raman scattering (SERS). [0003] The rough metal surface also enhances the fluorescence emission of nearby organic molecules by about 2 orders of magnitude, which is called surface-enhanced fluorescence (SEF). The surface-enhanced spectral function of metal materials is mainly derived from the surface plasmon (SPs) resonance f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N21/65B82Y15/00
Inventor 杨益民邱腾刘智畅
Owner SOUTHEAST UNIV
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