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Medical carboxymethyl chitosan anti-adhesion agent and preparation method thereof

A technology of carboxymethyl chitosan and anti-adhesion agent, which is applied in the field of medical anti-adhesion agent and its preparation, and can solve the problems of complex preparation formula, many preparation process steps, and cumbersome process.

Inactive Publication Date: 2012-10-10
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But its preparation formula is very complicated, and preparation process step is many, and process is loaded down with trivial details

Method used

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  • Medical carboxymethyl chitosan anti-adhesion agent and preparation method thereof
  • Medical carboxymethyl chitosan anti-adhesion agent and preparation method thereof
  • Medical carboxymethyl chitosan anti-adhesion agent and preparation method thereof

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Embodiment

[0028] I: Preparation of carboxymethyl chitosan

[0029] 1. Take fresh Alaskan cod crab leg shell, soak in 5% hydrochloric acid at 50°C for 24 hours, wash with purified water until neutral, then soak in 5% sodium hydroxide at 50°C for 24 hours, wash with purified water To neutrality, repeat the above operation once; dry to obtain crude chitin.

[0030] 2. Crush and sieve the crude chitin, take 30-mesh to 60-mesh granules, soak them in 1% hydrochloric acid at 50°C for 2 hours, wash with purified water until neutral; then soak them in 2% sodium hydroxide at 50°C for 2 hours, purify Wash with water until neutral; then soak in 1% hydrochloric acid at 50°C for 2 hours, wash with purified water until neutral; centrifuge and dry to obtain chitin.

[0031] 3. Take the chitin obtained in step 2, add it to the sodium hydroxide solution with a concentration of 51% in a ratio of 1:12, feed nitrogen, and carry out the acetylation reaction at a temperature of 140°C for 20 minutes; after th...

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Abstract

The invention relates to a medical anti-adhesion agent which comprises carboxymethyl chitosan and equilibrium liquid. The solvent of the equilibrium liquid is water for injection, and the solute of the equilibrium liquid comprises sodium chloride and monopotassium phosphate. The anti-adhesion agent comprises, in weight percent, 0.1%-10% of carboxymethyl chitosan, preferably 0.2%-5% of carboxymethyl chitosan, more preferably 0.5%-4.0% of carboxymethyl chitosan, 0.5%-1% of sodium chloride and 0.1%-2% of monopotassium phosphate. The invention further relates to a method for preparing the anti-adhesion agent. The anti-adhesion agent can be in the form of gel or flushing fluid, is used for preventing postoperative adhesion in general surgery department and gynecology and obstetrics, and can also be used for surgical or trauma flushing. The anti-adhesion agent is non-toxic, non-irritant, biodegradable and free of sensitization, and has fine antibacterial activity and anti-adhesion effects.

Description

technical field [0001] The invention relates to an anti-adhesion product with a new formula, in particular to a medical anti-adhesion agent in the form of carboxymethyl chitosan in gel or flushing solution and a preparation method thereof. Background technique [0002] In medical operations, many patients often experience different degrees of tissue adhesion at the surgical site after surgery, which can cause dysfunction. Preventing this kind of adhesion is of great significance to the rehabilitation of patients. Existing anti-adhesion products mainly use sodium dihydrogen phosphate, disodium hydrogen phosphate or supplemented with sodium gluconate, mannitol, etc. as stabilizers. [0003] For example, the inventor disclosed an anti-adhesion flushing solution in Patent Application No. 200510062206.8, and the phosphate auxiliary materials used in it were sodium dihydrogen phosphate and disodium hydrogen phosphate. However, the buffer solution of this invention mainly uses sod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/06A61K31/722A61K47/02A61P41/00
Inventor 刘胜军张彪高明李素哲李国付李勇刘玉东
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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