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Manufacturing method of antibacterial anti-adhesion medical gluing sucker

A glue application and anti-adhesion technology, applied in the field of smear straws, can solve the problems of poor antibacterial and anti-adhesion performance, low heat resistance and aging resistance, etc., so as to improve the heat resistance and aging resistance, prolong the service life, and improve the antibacterial performance. Effect

Active Publication Date: 2019-12-20
浙江派菲特新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above deficiencies in the prior art, the present invention provides a preparation method of an antibacterial and anti-adhesion medical glue smear straw, to solve the deficiencies of the existing medical glue smear straws with poor antibacterial and anti-adhesion properties, and heat and aging resistance The technical problem of low performance, thus improving the use effect of medical glue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of the antibacterial anti-adhesion medical glue smear straw of the present embodiment, it may further comprise the steps:

[0029] S1: Preparation of vinyl carbonate-based imidazole polycondensate: 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyoxyethyl ) undecyl hydrocarbonate and a catalyst were added to a high-boiling solvent, and under the protection of an inert gas, the reaction was stirred at 105°C for 18 hours, then precipitated in water, and the product was washed with ethanol for 3 times, and then dried to a constant weight , to obtain vinyl carbonate-based imidazole condensation polymer;

[0030] The 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyloxyethyl)undecyl hydrocarbonate, catalyst and high The mass ratio of the boiling point solvent is 2:1:0.3:10; the high boiling point solvent is selected from dimethyl sulfoxide; the catalyst is selected from sodium ethylate;

[0031] S2: Ionization modification of ...

Embodiment 2

[0038] The preparation method of the antibacterial anti-adhesion medical glue smear straw of the present embodiment, it may further comprise the steps:

[0039]S1: Preparation of vinyl carbonate-based imidazole polycondensate: 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyoxyethyl ) Undecyl hydrocarbonate and a catalyst were added to a high boiling point solvent, and under the protection of an inert gas, the reaction was stirred at 125°C for 15 hours, then precipitated in water, and the product was washed with ethanol for 5 times, and then dried to a constant weight , to obtain vinyl carbonate-based imidazole condensation polymer;

[0040] The 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyloxyethyl)undecyl hydrocarbonate, catalyst and high The mass ratio of the boiling point solvent is 1.8:1:0.1:6; the high boiling point solvent is selected from N-methylpyrrolidone; the catalyst is selected from sodium hydride;

[0041] S2: Ionization modificati...

Embodiment 3

[0048] The preparation method of the antibacterial anti-adhesion medical glue smear straw of the present embodiment, it may further comprise the steps:

[0049] S1: Preparation of vinyl carbonate-based imidazole polycondensate: 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyoxyethyl ) undecyl hydrocarbonate and a catalyst were added to a high-boiling solvent, under the protection of an inert gas, stirred and reacted at 105°C for 18 hours, then precipitated in water, washed the product 5 times with ethanol, and dried to constant weight , to obtain vinyl carbonate-based imidazole condensation polymer;

[0050] The 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol, 3,3-bis(2-carboxyloxyethyl)undecyl hydrocarbonate, catalyst and high The mass ratio of the boiling point solvent is 2.1:1:0.5:15; the high boiling point solvent is selected from dimethyl sulfoxide; the catalyst is selected from sodium amide;

[0051] S2: Ionization modification of vinyl carbonate-based imidazo...

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Abstract

The invention discloses a manufacturing method of an antibacterial anti-adhesion medical gluing sucker. The manufacturing method comprises the steps of 1, carrying out reaction on 1-methyl-2-vinyl-1H-benzimidazole-4,7-diol and 3,3-bis(2-carboxy oxyethyl)undecyl hydrogen carbonate to obtain vinyl carbonate imidazole polycondensate; 2, carrying out ionization modification on the vinyl carbonate imidazole polycondensate; 3, carrying out copolymerization reaction on octavinyl cage-type silsesquioxane and allyl diethylene glycol dicarbonate to obtain a carbonate-based cage-type silsesquioxane copolymer; and 4, uniformly mixing the modified vinyl carbonate imidazole polycondensate and the carbonate-based cage-type silsesquioxane copolymer, and then preforming extruding, stretching, cooling and slitting to obtain the medical gluing sucker. The medical gluing sucker has excellent antibacterial and anti-adhesion performance, and good heat and aging resistance.

Description

technical field [0001] The invention relates to the technical field of smearing straws, in particular to a preparation method of antibacterial and anti-adhesion medical glue smearing straws. Background technique [0002] Medical glue is an emerging medical product that replaces sewing needles. The main component of medical glue is a-cyanoacrylate, which has the fastest polymerization speed in biological tissues. Under the action of anions in wound blood and interstitial fluid, medical glue can quickly polymerize and solidify to form a film and inlay tightly with the wound, which can firmly maintain the apposition state of the wound, and the glue film can prevent blood cells and platelets from passing through. Under the joint action of protein, the broken small blood vessels on the wound surface can be effectively stopped bleeding, while the adhesive film isolates the tissue and bacteria, and also has the effect of anti-infection and protection of the wound surface. [0003]...

Claims

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Application Information

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IPC IPC(8): C08L51/08C08L79/04C08F283/12C08F218/00C08G73/06
CPCC08L51/085C08L79/04C08F283/124C08G73/0633C08L2203/02C08L2203/18C08L2201/08
Inventor 林闪光叶善明金艳应磊
Owner 浙江派菲特新材料科技有限公司
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