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Hemlock parsley phthalide type ingredient effective part as well as preparation method and application of hemlock parsley phthalide type ingredient effective part

An effective part, the technology of Ligusticum chuanxiong phthalide, which is applied in the field of extraction of effective components of Chinese medicinal materials, can solve the problems of supercritical fluid extraction equipment expensive, volatile components hydrolyzed, deteriorated, oxidized, etc., to achieve quality control and myocardial ischemia protection , the effect of clear chemical composition

Inactive Publication Date: 2012-10-10
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the steam distillation process will lead to hydrolysis and deterioration, rearrangement, oxidation, polymerization and resinization of volatile components, the volatile oil components are not exactly the same as the original components of Ligusticum chuanxiong, and the actual measured sample components and contents inconsistent with reality
The equipment of supercritical fluid extraction method is expensive, and the efficiency of percolation method is low, so it is difficult to modernize large-scale production
At present, the preparation by solvent method mainly focuses on solvent extraction and extraction process, and there are few reports on further purification process.

Method used

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  • Hemlock parsley phthalide type ingredient effective part as well as preparation method and application of hemlock parsley phthalide type ingredient effective part
  • Hemlock parsley phthalide type ingredient effective part as well as preparation method and application of hemlock parsley phthalide type ingredient effective part
  • Hemlock parsley phthalide type ingredient effective part as well as preparation method and application of hemlock parsley phthalide type ingredient effective part

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1. The preparation process of the active parts of the phthalides in Ligusticum chuanxiong

[0035] After pulverizing 1 kg of Rhizoma Chuanxiong medicinal material to be extracted, add 10 L of aqueous ethanol solvent (ethanol concentration is 80%), soak at room temperature for 24 hours, extract twice at 45° C. for 1 hour each time, filter to remove medicinal residues, and combine twice A total of 20 L of the filtrate was collected under reduced pressure at 45°C until the solvent had no alcohol smell, and 3 L of the concentrated solution of Rhizoma Chuanxiong was obtained. Add 1L of water to the concentrated extract of Chuanxiong Rhizoma Rhizoma Chuanxiong, mix well to prepare the extract, then add 2L of petroleum ether saturated with water in advance, extract once at 25°C, let stand for 48 hours to separate the layers, and collect the organic The petroleum ether extract of Ligusticum chuanxiong was obtained, the remaining water phase was added to 2 L of ethyl ace...

Embodiment 2

[0036] Example 2. Preparation process of effective parts of Angelica phthalides

[0037] After crushing 1 kg of angelica medicinal materials to be extracted, add 10 L of aqueous ethanol solvent (ethanol concentration is 80%), soak at room temperature for 24 hours, extract twice at 45° C. for 1 hour each time, filter to remove medicinal residues, and combine twice A total of 20 L of the filtrate was collected under reduced pressure at 45°C until the solvent had no alcohol smell, and 3 L of the concentrated solution of Angelica sinensis was obtained. Add 1L of water to the concentrated solution of angelica extract, mix well to make the solution to be extracted, then add 2L of petroleum ether saturated with water in advance, extract once at 40°C, let stand for 48 hours to separate the layers, and collect the organic phase, add an appropriate amount of anhydrous sodium sulfate to remove water, and obtain angelica petroleum ether extract. Pack 200g of silica gel (100-200 mesh) int...

Embodiment 3

[0038] Example 3. The preparation process of the effective parts of the compound chuanxiong angelica phthalide components

[0039] Grinding 1 kg of Rhizoma Chuanxiong and Angelica sinensis to be extracted (the ratio of the two medicinal materials is 1:1), adding 10 L of aqueous ethanol solvent (75% ethanol concentration), soaking at room temperature for 24 hours, and extracting twice at 45 ° C, each After 1 hour, the medicinal residues were removed by filtration, and a total of 20 L of the two filtrates were combined, and the solvent was recovered under reduced pressure at 45°C until there was no alcohol smell, and 3.5 L of the compound medicinal material extraction concentrate was obtained. Add 1L of water to the concentrated extraction solution, mix well to prepare the extraction solution, then add 1.5L of n-hexane saturated with water in advance, extract 3 times at 40°C, let stand for 2 hours to separate the layers, and collect the organic phase Obtain n-hexane extract. Ad...

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Abstract

The invention discloses a phthalide type ingredient effective part as well as a preparation method and an application of the phthalide type ingredient effective part and belongs to the technical field of traditional Chinese medicine and natural product extraction and application. The preparation method of the phthalide type ingredient effective part comprises the following steps that hemlock parsley medicinal materials are extracted by an ultrasonic extraction method, a solvent extraction method, a microwave extraction method, a solvent backflow extraction method or a supercritical fluid extraction method, extracts are added with water to be dispersed and are then respectively extracted by two different-polarity solvents, extraction liquid is purified by positive-phase silica gel, the content of the phthalide type ingredient effective part accounts for more than 50 percent of the total weight of the extracts, and in addition, different solid phase extraction operation modes can be adopted according to different ingredient requirements. The phthalide type ingredient effective part, the preparation method and the application have the advantages that the preparation speed is fast, the phthalide type ingredient content in the product is high, the ingredient is definite, the quality is controllable, and good economic benefits and social benefits are realized.

Description

technical field [0001] The invention belongs to the technical field of extracting effective components of traditional Chinese medicinal materials, and in particular relates to an effective part of chuanxiong phthalide components, a preparation method and an application. Background technique [0002] The traditional Chinese medicine Chuanxiong and Angelica are the dried rhizomes of the Umbelliferae plants Chuanxiong and Angelica. Pain, headache, rheumatic arthralgia and other symptoms are commonly used traditional Chinese medicines in prescriptions of traditional Chinese medicine, and they are also important raw materials of many Chinese patent medicines. Since 1977, Beijing Institute of Pharmaceutical Research named Tetramethylpyrazine as "Ligustrazine (TMP)" in the article titled "Research on the Active Components of Ligusticum Chuanxiong" published on the 7th issue of "Chinese Medical Journal", its pharmacological research Expand quickly. Ligustrazine can pass through th...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K36/232A61P9/10A61P7/02A61P25/06A23L1/29A23L33/00
Inventor 杨学东伍勋胡立翠
Owner TIANJIN UNIV
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