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Compound common andrographis herb taste-masking particles and preparation method thereof

A technology of taste-masking granules and Andrographis paniculata, applied in the field of pharmacy, can solve the problems of difficult taste-masking, large differences in properties, complex components, etc., and achieves the effects of obvious effect, simple preparation process, and easy industrial production.

Active Publication Date: 2014-05-07
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above studies mainly focus on the taste-masking research on single herbs, while the Andrographis paniculata compound preparation contains traditional Chinese medicines and chemical medicines, with complex components and large differences in properties, and includes Andrographis paniculata, amantadine hydrochloride, chlorpheniramine maleate, etc. Bitter ingredients, difficult to mask taste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Andrographis paniculata compound taste-masking granules include the following raw materials: Andrographis paniculata extract powder 40g, mixed extract powder 1450g, acetaminophen 2450g, amantadine hydrochloride 480g, chlorpheniramine maleate 8g, acesulfame potassium 80g, coating material 80g, made into 10000 capsules.

[0020] Among them, Andrographis paniculata extract powder is prepared by decocting the washed Andrographis paniculata with water 5 times the weight of the medicinal materials twice, each time for 60 minutes, combining the two decoctions, filtering and concentrating, and obtaining a liquid infusion with a relative density of 1.15 at 60°C. Cream, let the liquid extract cool to 20°C, slowly add ethanol while stirring to make the alcohol content of the liquid extract reach 60%, refrigerate for 48 hours, filter, and dry to obtain.

[0021] Among them, the mixed extract powder is to mix honeysuckle, Radix Isatidis, and dandelion of the same quality, add water ...

Embodiment 2

[0027] Andrographis paniculata compound taste-masking granules include the following raw materials: Andrographis paniculata extract powder 41.7g, mixed extract powder 1500g, acetaminophen 2500g, amantadine hydrochloride 500g, chlorpheniramine maleate 10g, acesulfame potassium 100g, coating Material 90g, made into 10000 grains.

[0028] Wherein the coating material includes the following weight ratio materials: 7 parts of film-forming material, 12 parts of plasticizer, 12 parts of antistatic agent; Sesame oil, plasticizer are PEG6000 and triethyl citrate of equal quality, and antistatic agent is magnesium stearate, talcum powder and micropowder cellulose of equal quality.

[0029] The preparation method of Andrographis paniculata compound taste-masking granules is as follows:

[0030] (1) Precisely weigh the medicinal powder and auxiliary materials according to the prescription, mix them in a high-efficiency pulverizer for 7 minutes, use 10% starch slurry to make soft material...

Embodiment 3

[0034] Andrographis paniculata compound flavor-masking granules include the following raw materials: Andrographis paniculata extract powder 43g, mixed extract powder 1550g, acetaminophen 2550g, amantadine hydrochloride 520g, chlorpheniramine maleate 12g, acesulfame potassium 120g, coating materials 100g, made into 10000 capsules.

[0035] Wherein the coating material comprises the following materials in weight ratio: 10 parts of film-forming material, 15 parts of plasticizer, 15 parts of antistatic agent; The plasticizer is triethyl citrate, and the antistatic agent is magnesium stearate and talcum powder of equal quality.

[0036] The preparation method of Andrographis paniculata compound taste-masking granules is as follows:

[0037](1) Precisely weigh the drug powder and auxiliary materials according to the prescription, mix them in a high-efficiency pulverizer for 10 minutes, make soft materials with 10% starch slurry, pass through a 250um sieve, granulate, bake at 50°C f...

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PUM

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Abstract

The invention discloses compound common andrographis herb taste-masking particles and a preparation method thereof. The taste-masking particles comprise common andrographis herb extract powder, mixed extract powder, acetaminophen, amantadine hydrochloride, chlorpheniramine maleate, acesulfame potassium, and a coating material; and the coating material comprises a film forming material, plasticizer and an antistatic agent. The compound common andrographis herb particles are coated by the compound coating material, so that the bitter taste and the peculiar smell of common andrographis herb extract, amantadine hydrochloride, chlorpheniramine maleate and the like are completely masked, and the medicine taking compliance is improved. The taste-masking particles also can be used for preparing various dry suspensions which are suitable for special crowds of children, the old and the like. The preparation process is relatively simple, and the compound common andrographis herb taste-masking particles are obvious in effect and are easy to industrially produce.

Description

technical field [0001] The invention relates to a compound taste-masking granule of Andrographis paniculata and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Chuanxinlian compound granule is a traditional Chinese medicine compound preparation, the main ingredients are andrographis paniculata, honeysuckle, dandelion, isatidis, acetaminophen, chlorpheniramine maleate and amantadine hydrochloride. The main effects are clearing heat and detoxifying, dispelling wind and relieving exterior syndrome. For common cold, influenza, wind-heat syndrome caused by exogenous pathogenic factors, symptoms include fever, headache, nasal congestion, runny nose, cough, sore throat. [0003] Andrographis paniculata has the effects of clearing heat and detoxifying, cooling blood and reducing swelling, and the contained andrographolide has antibacterial effect, and has no side effects and toxicity. Acetaminophen has antipyretic and analgesic effec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/355A61K9/16A61K47/32A61K47/34A61K47/38A61K47/42A61K47/44A61P11/00A61P25/04A61P29/00A61P31/16A61K31/13A61K31/167A61K31/4402
Inventor 罗晓健张国松饶小勇杨世林张尧王琦雷景邦黄恺孙莎莎
Owner JIANGXI HERBFINE HI TECH