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Breast nodule treatment medicine composition and preparation process and application thereof

A composition and drug technology, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of patients with fear, severe effects, and side effects, etc., to achieve definite curative effect and improve pathological symptoms , the effect of inhibiting precancerous lesions

Inactive Publication Date: 2012-10-10
四川省中医药科学院中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the current common prescriptions often contain products that have long-term safety hazards (such as Toosendan, Aokita, Sanzi mushroom, cat's claw, golden fruit olive, Chuanwu, Tiannanxing, star anise lotus, Chonglou , frankincense, myrrh), or medicinal materials with limited resources (such as ratwort, deer grass, cordyceps, black ants, antlers (cream), saponins), some drugs have severe effects, or have side effects that make people feel sick. Patients are fearful, so less drugs are actually used for the treatment of breast addiction, which is extremely disproportionate to the needs of such a large group of breast addiction patients

Method used

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  • Breast nodule treatment medicine composition and preparation process and application thereof
  • Breast nodule treatment medicine composition and preparation process and application thereof
  • Breast nodule treatment medicine composition and preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0047] 【prescription】

[0048] 556g white peony, 333g melon skin, 333g curcuma, 333g Cyperus cyperi, 333g green skin, 444g angelica, 111g scorpion, 444g turtle shell (made with vinegar), 333g kelp, 556g banzhilian, 444g prunella vulgaris, 444g poria cocos into 1000g granules.

[0049] 【Method】

[0050] Add 10 times the amount of water for the above twelve flavors, angelica, zedoary, Cyperus cyperi, and Qingpi, heat to extract the volatile oil for 4 hours, collect the aromatic water and redistill it to 462ml, add 34.67g of β-cyclodextrin, and grind it with a colloid mill for 30min. Put the grinding liquid in the refrigerator overnight, centrifuge, filter, dry and pulverize at 40°C for later use; extract the volatile oil and collect the medicinal liquid in another device for later use; add 10 times the dregs to the skin of Trichosanthes L., Scorpion, Turtle Shell, Kelp, and Poria amou...

Embodiment 2

[0052] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0053] Take by weighing the bulk drug according to the following formula:

[0054] 700g of white peony root, 250g of trichosanthes peel, 250g of curcuma, 400g of Cyperus cyperi, 250g of green peel, 350g of angelica, 80g of scorpion, 350g of turtle shell, 250g of kelp, 400g of Scutellaria barbata, 350g of Prunella vulgaris, 350g of poria cocos;

[0055] After being prepared into granules according to the method of Example 1, an appropriate disintegrant was added, and the tablet was compressed to obtain the tablet of the pharmaceutical composition of the present invention.

Embodiment 3

[0056] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0057] Take by weighing the bulk drug according to the following formula:

[0058] 500g of white peony root, 350g of Trichosanthes barbatus, 350g of curcuma, 350g of Cyperus cyperi, 350g of Qingpi, 500g of angelica, 120g of scorpion, 500g of turtle shell, 350g of kelp, 600g of Scutellaria barbata, 500g of Prunella vulgaris, 500g of Poria cocos;

[0059] After collecting the dry powder obtained by spray drying according to the method of Example 1, mix it with β-cyclodextrin-included volatile oil, add an appropriate amount of microcrystalline cellulose, mix it well, and pack it into capsules to obtain the capsules of the pharmaceutical composition of the present invention.

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Abstract

The invention discloses a breast nodule treatment medicine composition, which is prepared by active pharmaceutical ingredients: by weight, 400-700 parts of white paeony roots, 250-400 parts of snakegourd peel, 250-400 parts of rhizoma curcuma, 250-400 parts of rhizoma cyperi, 250-400 parts of green tangerine peel, 350-550 parts of Chinese angelica, 80-140 parts of scorpio, 350-550 parts of turtle shell, 250-400 parts of kelp, 400-700 parts of sculellaria barbata, 350-550 parts of selfheal and 350-550 parts of poria cocos. The medicine composition has good anti-inflammatory, analgesic, circulation promoting and stasis removing functions, and is capable of not only improving pathological symptoms of proliferation of mammary gland effectively but inhibiting precancerous lesion of breast cancer, and accordingly a new pharmacy choice is provided for clinical treatment of proliferation of mammary gland and prevention of breast cancer.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating breast addiction, a preparation method and application thereof. Background technique [0002] Breast addiction mainly refers to cystic hyperplasia of the breast. Western medicine believes that it is a disease that is neither inflammation nor tumor, but a disease of breast structure disorder that is formed by breast fibrous tissue and epithelial hyperplasia accompanied by cysts. Therefore, foreign scholars It's called fibrocystic mastopathy. The clinical manifestation of breast addiction is that breast pain and breast lump are the main clinical features. In order to facilitate the unification of the meaning of the disease name between Chinese and Western medicine, the State Administration of Traditional Chinese Medicine formulated the "Diagnostic and Curative Criteria for Diseases and Syndromes of Traditional Chinese Medicine" in 1995, which standardized the name and meaning of the dise...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P15/14A61K35/64A61K35/56A61K35/586A61K35/646
Inventor 谢守德严素芳李希欧亚龙张嵩陈东辉冯建安
Owner 四川省中医药科学院中医研究所
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