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Anti-infection mineralized collagen and calcium sulfate bone repair material and preparation method thereof

A technology for mineralized collagen and bone repair, applied in medical science, prosthesis, etc., can solve the problems of poor biocompatibility, short concentration time, non-degradation, etc., achieve good biocompatibility, good injectability, promote The effect of adhesive spreading

Active Publication Date: 2012-11-07
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PMMA has the disadvantages of short release time of effective drug concentration, poor biocompatibility, inability to degrade, and the need for reoperation to remove.

Method used

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  • Anti-infection mineralized collagen and calcium sulfate bone repair material and preparation method thereof
  • Anti-infection mineralized collagen and calcium sulfate bone repair material and preparation method thereof
  • Anti-infection mineralized collagen and calcium sulfate bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Hydrothermal method to prepare α-type calcium sulfate hemihydrate: CaSO 4 ·2H 2 O, added to the reaction kettle, respectively take CaSO 4 ·2H 2 O 0.25% sodium citrate and aluminum sulfate are added to the reactor, and then CaSO 4 ·2H 2 Deionized water of 5.67 times the mass of O, airtight the reactor, stir at 120°C, and react for 6 hours; after the reaction is completed, the reaction solution is hot and filtered, and then the filter cake is washed with deionized boiling water. The filtrate during the whole process And the temperature of the rinsing liquid is above 90℃; put the drained filter cake in a drying box at 100℃ and dry overnight to obtain α-type calcium sulfate hemihydrate; grind with a mortar, sieving with a 100 mesh stopper, and obtain a uniform particle size Alpha-type calcium sulfate hemihydrate powder.

[0019] Preparation of mineralized collagen: Dissolve collagen with a solid content of 1% in glacial acetic acid, the concentration of the collagen solution is...

Embodiment 2

[0022] The preparation of mineralized collagen and α-type calcium sulfate hemihydrate was the same as in Example 1.

[0023] Add mineralized collagen, vancomycin, and calcium sulfate dihydrate in the proportions of 2 wt %, 10 wt %, and 20 wt% respectively into the remaining α-type calcium sulfate hemihydrate and mix well to obtain anti-infective mineralized collagen-sulfuric acid Calcium bone repair material.

Embodiment 3

[0025] The preparation of mineralized collagen and α-type calcium sulfate hemihydrate was the same as in Example 1.

[0026] Add mineralized collagen, vancomycin, and calcium sulfate dihydrate in the proportions of 2 wt %, 15 wt %, and 20 wt% respectively into the remaining α-type calcium sulfate hemihydrate and mix well to obtain anti-infective mineralized collagen-sulfuric acid Calcium bone repair material.

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PUM

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Abstract

The invention belongs to the technical field of biomedical materials, and discloses an anti-infection mineralized collagen and calcium sulfate bone repair material and a preparation method thereof. The material is composite powder comprising 2-5wt% of mineralized collagen, 5-15wt% of vancomycin, 20-25wt% of calcium sulfate dihydrate and the balance alpha-type calcium sulfate hemihydrate. The alpha-type calcium sulfate hemihydrate is prepared by a hydrothermal method, the mineralized collagen is prepared by a biological mineralization method, and the alpha-type calcium sulfate hemihydrate, the mineralized collagen, the vancomycin and the coagulant calcium sulfate dihydrate are mixed to prepare the anti-infection mineralized collagen and calcium sulfate bone repair material with a certain component ratio. When the liquid / solid ratio is 0.5-0.8mL / g, the material has a fine self-setting performance, is degradable, slowly releases medicines, and is anti-infection. Besides, the material has fine biocompatibility and can promote adhesion and spreading of osteoblasts.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to an anti-infective mineralized collagen-calcium sulfate bone repair material and a preparation method thereof. Background technique [0002] In recent years, the incidence of post-traumatic osteomyelitis is increasing due to increasing traffic accidents and construction engineering accidents. Traumatic osteomyelitis not only has bone tissue infection, but also is often accompanied by fractures, bone exposure, bone defects, etc., which is more difficult to treat. At present, methods such as debridement, perfusion and irrigation are often used. After the infection is cured, bone graft surgery is performed. The treatment time is long, the number of operations is large, and the success rate is low. Many patients have disabilities such as shortened limbs, deformities, and joint dysfunction. [0003] Implanting the drug-loaded bone material into the focal site of the i...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/56A61L27/40A61L27/24A61L27/02
Inventor 连小洁王秀梅崔福斋何志敏张晓军
Owner TSINGHUA UNIV
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