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Compound clotrimazole combination for treating livestock dermatomycosis and preparation method thereof

A technology of dermatophytosis and compound clotrimazole, which is applied in the direction of skin diseases, antifungal agents, and drug combinations, can solve problems such as difficulty in reaching the parasitic site of pathogens, insignificant transdermal promotion effect, and insufficient outstanding effect, etc., to achieve Evenly mixed step by step, significant curative effect, enhanced antifungal effect

Inactive Publication Date: 2012-11-21
QINGDAO LVMAN BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, antifungal drugs are mostly used in the treatment of this disease, because most of the pathogens of this type of disease parasitize on the surface and deep part of the skin of affected animals at the same time, and nowadays most antifungal drugs are single preparations, and oral antifungal drugs have toxic side effects such as carcinogenicity and teratogenicity ; The transdermal preparations for the treatment of such diseases have no obvious transdermal promotion effect, and it is difficult to reach the parasitic site of the pathogen when treating deep fungal infections.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method for the compound clotrimazole composition for the treatment of livestock dermatophytosis, carried out as follows: (every part is calculated by 10g)

[0021] (1) Weigh 30 parts of stearic acid, 30 parts of white petrolatum, 240 parts of liquid paraffin, 20 parts of castor oil, and 4 parts of ethyl paraben in parts by weight, mix and heat in a water bath at 60°C to 65°C until melted Finally, add 20 parts of ketoconazole and 30 parts of clotrimazole, and stir until uniform;

[0022] (2) Weigh 10 parts of sodium lauryl sulfate, 10 parts of PEG-4000 and 600 parts of distilled water, heat at the same temperature, and stir until uniform;

[0023] (3) Slowly add (1) to (2), add 10 parts of essence, stir evenly and filter to get the product.

Embodiment 2

[0025] A preparation method for the compound clotrimazole composition for the treatment of livestock dermatophytosis, carried out as follows: (every part is calculated by 10g)

[0026] (1) Weigh 40 parts of stearic acid, 40 parts of white petrolatum, 260 parts of liquid paraffin, 30 parts of castor oil, and 4 parts of ethyl paraben in parts by weight, mix and heat in a water bath at 60°C to 65°C until melted Finally, add 30 parts of ketoconazole and 40 parts of clotrimazole, and stir until uniform;

[0027] (2) Weigh 20 parts of sodium lauryl sulfate, 20 parts of PEG-400, and 500 parts of distilled water, heat at the same temperature, and stir until uniform;

[0028] (3) Slowly add (1) to (2), add 20 parts of essence, stir well and filter to get the product.

Embodiment 3

[0030] A preparation method for the compound clotrimazole composition for the treatment of livestock dermatophytosis, carried out as follows: (every part is calculated by 10g)

[0031] (1) Weigh 50 parts of stearic acid, 50 parts of white petrolatum, 280 parts of liquid paraffin, 40 parts of castor oil, and 4 parts of ethyl paraben in parts by weight, mix and heat in a water bath at 60°C to 65°C until melted Finally, add 40 parts of ketoconazole and 50 parts of clotrimazole, and stir until uniform;

[0032] (2) Weigh 30 parts of sodium lauryl sulfate, 30 parts of PEG-400, and 400 parts of distilled water, heat at the same temperature, and stir until uniform;

[0033] (3) Slowly add (1) to (2), add 30 parts of essence, stir evenly and filter to get the product.

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PUM

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Abstract

The invention relates to a compound clotrimazole combination for treating livestock dermatomycosis and a preparation method thereof. The combination is prepared by uniformly mixing the following components in parts by weight: 3-5 parts of clotrimazole, 2-4 parts of ketoconazole, 1-3 parts of lauryl sodium sulfate, 3-5 parts of octadecanoic acid, 3-5 parts of white vaseline, 24-28 parts of liquid paraffin, 2-4 parts of castor oil, 0.4 parts of ethylparaben, 1-3 parts of PEG-400 (polyethylene glycol-400), 1-3 parts of essence, 40-60 parts of distilled water and the like. The compound clotrimazole combination has the beneficial effects of reasonable formulation, simplicity in preparation, quite obvious curative effect and special livestock dermatomycosis treatment effect proven by clinical application.

Description

technical field [0001] The invention relates to a compound clotrimazole composition for treating dermatophytosis of livestock and a preparation method thereof, belonging to the field of animal medicine, in particular to a compound clotrimazole composition for treating dermatophytosis of livestock and a preparation method thereof. Background technique [0002] Livestock dermatophytosis is a zoonotic infectious disease with high morbidity, strong contagiousness and difficult cure caused by fungi parasitic on the skin and mucous membranes of livestock. Suffering animals showed flushing of the skin, accompanied by exudative inflammation, and then turned into rust-colored or brown plaque lesions, and finally spread to the whole body. At this time, the affected animals lose their appetite, their growth and development are hindered, and their resistance decreases. They may be infected with other diseases or die from excessive emaciation. [0003] In livestock, the disease mainly i...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P31/10A61P17/00A61K31/4174
Inventor 周庆福刘文利
Owner QINGDAO LVMAN BIOLOGICAL ENG
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