Method for preparing sevelamer carbonate

A technology of sevelamer carbonate and sevelamer hydrochloride, which is applied in the field of biomedicine, can solve the problems of high impurity content of sevelamer carbonate and the impact on the quality of sevelamer carbonate, so as to save reaction time and solvent, Strong anti-pollution ability and accelerated mass transfer speed

Inactive Publication Date: 2012-11-28
NEW FOUNDER HLDG DEV LLC +2
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Yet the impurity content in the carbonic acid sevelamer that this method prepares is high, has influenced the quality of carbonic acid sevelamer

Method used

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  • Method for preparing sevelamer carbonate
  • Method for preparing sevelamer carbonate

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Add 300g of sevelamer hydrochloride granules to 2000ml of 5% sodium hydroxide solution. After stirring for 4 hours, add deionized water to wash until the pH value of the washing solution is nearly neutral to obtain alkaline sevelamer cation Resin.

[0051] Put 2000ml sulfonic acid cation exchange resin into an empty resin column with a height-to-diameter ratio of 10:1 after conventional pretreatment, add 600g sodium carbonate solution, and wash with water until the effluent aqueous solution is neutral. Ingredients are carbonate ions. The above aqueous solution is continuously added to the alkaline sevelamer cationic resin, washed with water, and circulated until the outflowing aqueous solution is neutral, and the cationic resin is collected to obtain sevelamer carbonate. Then sevelamer carbonate was added to the Soxhlet extraction reactor, 2L of isopropanol was added to extract impurities, and finally the residue in the Soxhlet extraction reactor was collected, washed wit...

Embodiment 2

[0053] Add 300g of sevelamer hydrochloride granules to 2000ml of 5% potassium hydroxide solution and stir for 4 hours to obtain an alkaline dispersion of sevelamer, and then pour the dispersion into a height-to-diameter ratio of 10:1 In the empty resin column, add deionized water to wash until the pH value of the eluent is nearly neutral, and then wash the resin with methanol until the weight content of water in the methanol is less than 0.3% to obtain the basic sevelamer cation Resin.

[0054] Load 2000ml of sulfonic acid cation exchange resin into an empty resin column with a height-to-diameter ratio of 10:1, add 600g of sodium carbonate solution and wash with water until the outflowing aqueous solution is neutral, and the main component of the aqueous solution is carbonate ion . The above aqueous solution is continuously added to the above alkaline sevelamer cation resin, the volume ratio of carbonate solution and alkaline sevelamer cation resin is 6:1, washing with water and...

Embodiment 3

[0056] This example is basically the same as Example 1, except that after adding sevelamer carbonate to the Soxhlet extraction reactor, 10 times the volume of sevelamer carbonate is added to extract impurities, and finally the Soxhlet extraction reaction is collected The residue in the vessel, the ether was removed, filtered, ground, and sieved to obtain 250 g of a white granular solid, namely: carbonate of Sevelamer, with a purity of 99.3%.

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Abstract

The invention provides a method for preparing sevelamer carbonate. The method comprises the following steps: a) washing alkaline sevelamer with water until neutrality to obtain an alkaline sevelamer cationic resin; and b) mixing a carbonic acid solution and the alkaline sevelamer cationic resin to obtain the sevelamer carbonate. By the method for preparing the sevelamer carbonate, the sevelamer carbonate has high purity; and in addition, by a Soxhlet extraction method, the mass transfer velocity can be improved and the reaction time is saved.

Description

Technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of sevelamer carbonate. Background technique [0002] Aliphatic polyamine cationic resins mainly include sevelamer hydrochloride, sevelamer, sevelamer carbonate and any other possible salts, colesevelam hydrochloride, etc. These products have been used in the treatment of diseases, mainly for the treatment of hyperphosphatemia, hyperlipidemia, diabetes, gout, lowering uric acid, and even adsorption of related ions. The application principle of this type of aliphatic polyamine is essentially the adsorption of resin. The adsorption effect of resin has been widely used in industry, agriculture or environmental protection industries. [0003] Sevelamer carbonate is an aliphatic polyamine polymer, and its preparation method has been disclosed in the prior art. The preparation method is disclosed in the US Patent Application Publication No. US2010 / 013742, which is specifical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G73/02
Inventor 郭欲晓徐环昕易崇勤王振国丁继军李劲任爱国
Owner NEW FOUNDER HLDG DEV LLC
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