Composite medicine carrying vessel stent and preparation method thereof

Abstract

The invention discloses a composite medicine carrying vessel stent and a preparation method thereof and relates to vessel stents, in particular to a femtosecond laser patterning gradient composite medicine carrying vessel stent. Surface microstructures having good wettability with carried medicines are processed on the surface of a metal stent through femtosecond laser, a hyaluronic acid (HA) carried vascular endothelial growth factor (VEGF) medicine layer formed by HA and VEGF which are co-deposited is arranged on the surface of the metal stent, and a medicine coating for inhibiting multiplication of vascular smooth muscle cells (VSMCs) or a medicine coating for inhibiting multiplication of the VSMCs and a medicine coating for inhibiting platelet aggregation, namely, an anticoagulant medicine coating, are coated on the VEGF medicine layer. The composite medicine carrying vessel stent overcomes the shortcomings that beneficial effects of medicines for inhibiting VSMCs and medicines for promoting vascular endothelial cells (VECs) are inhibited due to mutual influence when the medicines for inhibiting VSMCs and medicines for promoting VECs are carried on the surface of the vessel stent simultaneously in the prior art; and covering of the medicines on the surface of the stent is incomplete due to the fact that the binding force between a base body and a medicine carrying layer coated on the surface of the smooth metal stent is poor, and the medicine carrying layer is easily stripped and falls off when the vessel stent is opened.

Description

technical field [0001] The technical solution of the present invention relates to a vascular stent, specifically a composite drug-loaded vascular stent and a preparation method thereof. Background technique [0002] For the convenience of writing, the Chinese term names used in the following English abbreviations are first listed: ISR-in-stent restenosis, VSMC-smooth muscle cells, RS-restenosis, DES-drug-eluting stents, VEC-vascular endothelial cells, HA- Hydroxyapatite, VEGF-vascular endothelial growth factor, RAPA-rapamycin, HP-heparin, PLGA-polylactic acid-glycolic acid copolymer, PBS-phosphate buffer saline. [0003] Cardiovascular disease is one of the major diseases threatening human health, and coronary atherosclerotic heart disease (CHD for short) is the most important component of cardiovascular disease. The initial treatment of coronary heart disease mainly relies on drug therapy, but its curative effect is not good, and long-term medication is required. At prese...

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a composite drug-loaded vascular stent and a preparation method thereof, which is a femtosecond laser patterned gradient composite drug-loaded vascular stent and a preparation method thereof, which overcomes the problem of inhibiting VSMC in the prior art. When the drug and the drug that promotes VEC are simultaneously loaded on the surface of the stent, the beneficial effects of both are inhibited, and the drug-loaded layer coated on the surface of the smooth metal stent has poor binding force to the matrix. When stretching, it is easy to peel off and fall off the drug-loaded layer due to deformation, resulting in incomplete drug coverage on the surface of the stent

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