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Phenylephrine hydrochloride oral instant membrane and preparation method thereof

A technology of phenylephrine hydrochloride and oral instant film, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. The effect of high medication compliance and simple preparation process

Inactive Publication Date: 2013-01-16
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the structure of ephedrine and its synthetic derivative Methamphetamine (Methamphetamine) is similar, it can be extracted to produce methamphetamine, which has caused serious social harm and public health problems

Method used

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  • Phenylephrine hydrochloride oral instant membrane and preparation method thereof
  • Phenylephrine hydrochloride oral instant membrane and preparation method thereof
  • Phenylephrine hydrochloride oral instant membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Each tablet contains 10.0mg of phenylephrine hydrochloride, and the composition of every 1000 tablets of phenylephrine hydrochloride film is:

[0023]

[0024] The preparation method of phenylephrine hydrochloride oral cavity instant film provided by the invention comprises the steps:

[0025] A. Prepare the drug resin suspension containing phenylephrine hydrochloride: take phenylephrine hydrochloride, dissolve it with 500 times (V / W) water, add polacrilin potassium resin after stirring and dissolving at room temperature, and continue stirring Ion exchange for 1 hour to obtain phenylephrine hydrochloride drug resin suspension;

[0026] B. Mixing and film coating: Add microcrystalline cellulose and sucralose to the suspension obtained in A, stir to disperse evenly, then add sodium carboxymethylcellulose, let it stand for swelling for 1 hour, and then add it under stirring 0.3% xanthan gum aqueous solution, after stirring evenly, add 30% glycerin aqueous solution, 0.3...

Embodiment 2

[0030] Each tablet contains 10.0mg of phenylephrine hydrochloride, and the composition of every 1000 tablets of phenylephrine hydrochloride film is:

[0031]

[0032] The preparation method of phenylephrine hydrochloride oral cavity instant film provided by the invention comprises the steps:

[0033] A. Prepare the drug resin suspension containing phenylephrine hydrochloride: take phenylephrine hydrochloride, dissolve it with 500 times (V / W) water, add polacrilin potassium resin after stirring and dissolving at room temperature, and continue stirring Ion exchange for 1 hour to obtain phenylephrine hydrochloride drug resin suspension;

[0034] B. Mixing and film coating: add microcrystalline cellulose and aspartame to the suspension obtained in A, stir to disperse evenly, then add hypromellose, let it stand for swelling for 1 hour, and then add it under stirring 0.3% xanthan gum aqueous solution, after stirring evenly, add 30% glycerin aqueous solution, 0.3% carmine pigment...

Embodiment 3

[0038] Each tablet contains 10.0mg of phenylephrine hydrochloride, and the composition of every 1000 tablets of phenylephrine hydrochloride film is:

[0039]

[0040]

[0041] The preparation method of phenylephrine hydrochloride oral cavity instant film provided by the invention comprises the steps:

[0042] A. Preparation of drug resin suspension containing phenylephrine hydrochloride: take phenylephrine hydrochloride, dissolve it in 500 times (V / W) water, add polacrilin bell resin after stirring and dissolving at room temperature, and continue stirring Ion exchange for 1 hour to obtain phenylephrine hydrochloride drug resin suspension;

[0043] B. Mixing and film coating: Add microcrystalline cellulose and sucralose to the suspension obtained in A, stir to disperse evenly, then add sodium carboxymethylcellulose, let it stand for swelling for 1 hour, and then add it under stirring 0.3% xanthan gum aqueous solution, after stirring evenly, add 30% glycerin aqueous solut...

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Abstract

The invention belongs to the field of a medicine technology which relates to a phenylephrine hydrochloride oral instant membrane and a preparation method of the phenylephrine hydrochloride oral instant membrane. The phenylephrine hydrochloride oral instant membrane is good in taste, capable of being quickly dissolved or disintegrated in an oral cavity, quickly released, and rapidly absorbed and taken effect in gastrointestinal tracts after the phenylephrine hydrochloride oral instant membrane is swollen. The phenylephrine hydrochloride oral instant membrane provided by the invention is utilized to eliminate nasopharyngeal mucosa hyperemia, relieve nasal mucosa hyperemia and swelling, and alleviate a nasal obstruction symptom caused by cold, influenza, an allergic reaction or non-allergic rhinitis and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a phenylephrine hydrochloride oral instant film and a preparation method thereof. Nasal congestion caused by allergic rhinitis, etc. Background technique [0002] Colds are upper respiratory tract catarrhal diseases caused by viruses, mixed infections or allergies; most are caused by respiratory viruses, of which coronaviruses and rhinoviruses are the main pathogenic viruses. The virus invades the mucous membrane, especially the nasal mucous membrane, which can dilate blood vessels, congest the tissue, increase secretions, affect the ventilation of the nasal cavity, block one or both sides of the nasal cavity, and cause nasal congestion. It can be relieved after blowing the nose, often accompanied by dizziness, headache, fatigue, lack of concentration, memory loss, backflow of nasal mucus, sputum entering the pharynx and spitting out of the mouth. [0003] Nasal congest...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/32A61K31/137A61K47/48A61K47/36A61K47/40A61K47/32A61P11/00A61K47/38
Inventor 赵伟卢欣李化淋
Owner 天津市聚星康华医药科技有限公司
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