Fc fusion protein of long-acting recombinant human growth hormone

A fusion protein, hgh-l-vfc technology, applied in the fields of molecular biology and medicine, can solve the problems of no half-life GH derivatives, difficulties in the construction of hGH-L-vFc fusion protein and the like
CN102875683BActive Publication Date: 2014-06-11PHARMAB
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PHARMAB
Publication Date
2014-06-11

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Abstract

The invention discloses a Fc fusion protein of long-acting recombinant human growth hormone. The Fc fusion protein (hGH-L-vFc fusion protein) disclosed herein contains human growth hormone, flexible peptide linker of about 2-20 amino acids, and human IgG Fc mutant. The Fc mutant is not lytic and has tiny side effect of adverse Fc-mediator. The invention further discloses a method for preparing or generating the fusion protein with high expression level. The hGH-L-vFc fusion protein disclosed herein has prolonged serum half-life period and increased biological activity, so as to improve the pharmacokinetics and drug efficacy, and needs few times of injection required in treatment.
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Description

technical field

[0001] The present invention relates to the fields of molecular biology and medicine. More specifically, the present invention relates to a long-acting recombinant human growth hormone Fc fusion protein and its preparation method and use. Background technique

[0002] Human growth hormone (hGH) is a peptide hormone with a full-length 191 amino acids and a molecular weight of 22 kDa, which is produced and released by the pituitary gland. It is involved in the regulation of normal growth and development in most people, is the main hormone that stimulates body growth, and exhibits a variety of biological effects, including linear growth, physique formation, lactation, macrophage activation, and insulin-like effects. In addition, growth hormone can stimulate the metabolism of bone, cartilage and muscle.

[0003] Growth hormone and its specific growth hormone receptor (hGHR) bind to each other on the surface of target cells, mediating biochemical cascade reactio...

Claims

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