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Polyether random copolymer and preparation method thereof

A technology of random copolymers and polyethers, applied in the field of polymers, can solve the problems of no modifiable side groups, limited applications, and can not provide hydrophobic groups, etc., and achieves high use value and good cell targeting. The effect of stability and wide application prospects

Active Publication Date: 2013-01-16
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polyethers in the prior art do not have modifiable side groups and cannot provide hydrophobic groups, making them mainly used in the modification of protein drugs, which limits the application of polyethers in the biomedical field

Method used

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  • Polyether random copolymer and preparation method thereof
  • Polyether random copolymer and preparation method thereof
  • Polyether random copolymer and preparation method thereof

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preparation example Construction

[0052] The present invention provides a preparation method of the polyether random copolymer described in the above technical scheme, which comprises the following steps:

[0053] Polymerizing the anionic initiator, the first polymerization monomer and the second polymerization monomer in an anhydrous solvent to obtain a polyether random copolymer;

[0054] The anionic initiator is prepared according to the following method:

[0055] Under an inert gas atmosphere, reacting a fused-ring aromatic hydrocarbon with a benzene ring number of 1 to 5 and an alkali metal in an anhydrous solvent to obtain the first reaction product;

[0056] Reacting the first reaction product with an alcohol compound having 1 to 10 carbon atoms to obtain an anionic initiator;

[0057] The first polymerized monomer and the second polymerized monomer are selected from ethylene oxide, propylene oxide, butylene oxide, 2-isopropoxyethylene oxide, 2-(3-allyl Oxy) ethylene oxide, 2-phenoxy ethylene oxide, 2-benzyloxy ...

Embodiment 1

[0072] Under a dry inert gas atmosphere, add 5 g (0.039 mol) of naphthalene, 1.52 g (0.039 mol) of potassium and 100 mL of anhydrous tetrahydrofuran to a clean and dry reaction flask, and after reacting at 15°C for 5 hours, add 3-allyl alcohol 2.26g (0.039mol), reacted at 15°C for 24h to obtain an initiator solution.

Embodiment 2

[0074] Under a dry inert gas atmosphere, add 5 g (0.039 mol) of naphthalene, 1.52 g (0.039 mol) of potassium and 100 mL of anhydrous tetrahydrofuran to a clean and dry reaction flask, and after reacting at 25°C for 5 hours, add 3-allyl alcohol 2.26g (0.039mol), reacted at 25°C for 24h to obtain an initiator solution.

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Abstract

The invention provides a polyether random copolymer which has a structure as shown in formula (I). The polyether random copolymer provided by the invention has an amphiphilic group, which provides the obtained polyether random copolymer with amphiphilicity, and thus the polyether random copolymer can be self-assembled into nanoparticles and can be used as a drug carrier and the like; in addition, end groups and / of side groups of the polyether random copolymer provided by the invention have double bond function groups, and thus through reactions of a mercapto group with the double bonds, the modification of the polyether random copolymer is realized; the polyether random copolymer is provided with functions of tissue and cell targeting, environment responsiveness and the like; therefore, the polyether random copolymer provided by the invention has high application value and wide application prospects in biomedicine. Experiment results show that the polyether random copolymer provided by the invention can be modified by folic acid further, and the obtained folic acid-modified polyether random copolymer has cell targeting; the method for preparing the polyether random copolymer provided by the invention has a yield of about 90%.

Description

Technical field [0001] The invention relates to the technical field of polymers, in particular to a polyether random copolymer and a preparation method thereof. Background technique [0002] Polyether, that is, polyethylene oxide, is a type of (-CH 2 CH 2 O-) is a polymer of structural units. Polyether has a very wide range of applications in the biomedical field because it has the following excellent properties: [0003] 1. The synthesis method is simple and controllable. Polyethers are mainly prepared by anionic living ring-opening polymerization, which is the classic and most effective method for synthesizing block copolymers with clear structures. End-functionalized polymers can be obtained by anionic polymerization technology, and block copolymers can be obtained by sequential feeding; [0004] 2. Very good solubility in water. Polyether has high solubility in water, phosphate buffer solution and physiological saline; [0005] 3. The toxic and side effects to the human body a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/22C08G65/12A61K47/34
Inventor 陈学思丁建勋庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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