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Graphene quantum dot modified electrochemical sensor, and preparation method and application thereof

A graphene quantum dot and sensor technology, applied in the direction of electrochemical variables of materials, can solve problems such as poor stability and performance, and achieve the effect of good biocompatibility and wide application prospects

Inactive Publication Date: 2013-01-16
SHANGHAI JIAO TONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, graphene quantum dot modified electrodes are mostly based on physical adsorption, and their stability is poor.

Method used

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  • Graphene quantum dot modified electrochemical sensor, and preparation method and application thereof
  • Graphene quantum dot modified electrochemical sensor, and preparation method and application thereof
  • Graphene quantum dot modified electrochemical sensor, and preparation method and application thereof

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Embodiment 1

[0026] An electrochemical sensor modified by graphene quantum dots, the electrochemical sensor is a three-electrode system sensor, wherein the counter electrode is a platinum electrode, the reference electrode is a saturated Gangon electrode, and the working electrode is modified by chemically bonded graphene quantum dots gold electrodes.

[0027] Among them, the gold electrode modified by graphene quantum dots is prepared by the following method: (1) the gold electrode (3 mm in diameter) is sequentially used on the polishing cloth with 1.0 μm, 0.3 μm, 0.05 μm Al 2 o 3 Powder polished to a mirror finish. After each polishing, ultrasonically clean in ultrapure water for 1 min, then ultrasonically clean with ultrapure water and ethanol for 5 min, then wash with a large amount of ultrapure water, and blow dry with nitrogen. (2) Immerse the clean gold electrode in hot H 2 o 2 / Concentrated H 2 SO 4 (1 / 3) in the mixed solution for 1 min, take it out and rinse it with a large...

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Abstract

The invention relates to a graphene quantum dot modified electrochemical sensor, and a preparation method and application thereof. A three-electrode system is adopted for the sensor, and a graphene quantum dot modified gold electrode is taken as a working electrode. Chemical bonds are used for bonding carboxylic groups of graphene quantum dots and amino groups on the surface of the modified gold electrode to construct the graphene quantum dot modified electrochemical sensor. The graphene quantum dot modified gold electrode is taken as the working electrode, and chronoamperometry is used for determining a working curve of H2O2 concentration. The linear range of the H2O2 concentration is determined to be 2 mu M to 8mM, and a detection lower limit is 1.3 mu M. In addition, the sensor can be used for detecting the content of H2O2 released by living cells in real time, has the advantages of quick response, wide linear range, low detection lower limit, broad application prospect and the like, and is significant for diagnostic tests in diseases caused by reactive oxygen species (ROS).

Description

technical field [0001] The invention relates to the preparation of an electrochemical sensor, in particular to an electrochemical sensor of a graphene quantum dot modified gold electrode and the H released by living cells. 2 o 2 content detection. Background technique [0002] A series of reactive oxygen species (reactive oxygen species, ROS) produced in the process of cell metabolism play an important role in the process of cell metabolism. When the content of ROS is low, it can be used as a second messenger such as growth factor and signal transmission. However, excessive ROS concentration can lead to a series of physiological lesions such as neuronal degeneration, cardiovascular disease, Alzheimer's disease, cancer and so on. Therefore, the determination of ROS content is of great significance to the study of physiological lesions and early diagnosis. However, in ROS · OH, O 2 -·Isomolecules cannot exist stably and are inconvenient for detection. As a kind of ROS, h...

Claims

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Application Information

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IPC IPC(8): G01N27/26G01N27/30
Inventor 郭守武张艳吴海霞杨海军
Owner SHANGHAI JIAO TONG UNIV
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