Method for extracting and separating ginkgolide B from ginkgo leaves
A technology of ginkgolide and ginkgo biloba, applied in the direction of organic chemistry, etc., can solve the problems of ginkgolide B, such as complex process, difficult industrial production, and high cost, and achieve the effects of good dispersibility, small solvent loss, and low cost
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specific Embodiment approach 1
[0027] Specific embodiment one: a kind of method of extracting and separating ginkgolide B from ginkgo leaf of the present embodiment is as follows:
[0028] 1. Take ginkgo biloba leaves, add 10 to 15 times the mass of ethanol solution with a mass percentage of 50% to 95%, heat and reflux for 1 to 3 hours, filter, collect the filtrate, concentrate under reduced pressure to remove ethanol, and obtain concentrated solution A;
[0029] 2. Add water to the concentrated solution A obtained in step 1 to dissolve until the concentrated solution A contains 0.1-0.3 g / mL of crude drug, then place it at room temperature for 24-48 hours, take the upper layer, and set aside;
[0030] 3. Concentrate the supernatant liquid obtained in step 2 under reduced pressure until the crude drug content is 0.5~1.5g / mL, then pass through the macroporous resin column at a speed of 0.5~3BV / h, and first elute with water at a speed of 0.5~3BV / h, Then use ethanol solution with a mass percentage of 50%~95% to...
specific Embodiment approach 2
[0039] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the ginkgo leaf described in step one is ginkgo leaf coarse powder. Others are the same as in the first embodiment.
specific Embodiment approach 3
[0040] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the macroporous resin described in step three is one or more of NKA-9, ADS-2, SA-1, SA-2 A mixture composed in any ratio. Others are the same as in the first or second embodiment.
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