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Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation

A technology for phosphatidylserine and stable preparations, which is applied in the fields of biomedicine and food processing, and can solve problems such as difficult production and preparation, easy oxidation and discoloration, and unstable physical and chemical properties

Active Publication Date: 2013-02-06
连平劲创生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its physical and chemical properties are extremely unstable, and it is easy to oxidize, discolor and degrade when applied, resulting in a disgusting smell of expired oil
Not only is it not easy to produce and prepare, but it is also easy to affect the quality of the final product

Method used

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  • Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation
  • Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation
  • Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Add 100 grams of sodium alginate to 1 liter of purified water at 50-60°C and stir to form a uniform aqueous solution. Gradually add 200 grams of ground phosphatidylserine roughened product (containing 50 parts of phosphatidylserine), fully stir and homogenize. Another 1 liter of 50-60° C. purified gelatin aqueous solution was prepared, with a concentration of 5%. Stir constantly in a constant temperature water bath to swell completely. The above-mentioned sodium alginate solution and gelatin solution are combined and fully stirred to form a cystic solution. Add purified water (V / V, 1:1) to the cyst-forming solution, adjust the pH range to 3.9-4.2 with an appropriate amount of 5% dilute acetic acid; 2 As a curing agent, lower the temperature and control the temperature at 10°C to 15°C to form microcapsules of phosphatidylserine. The microcapsules were collected by filtration, washed with water, dried, and set aside.

[0068] In other embodiments of the present invent...

Embodiment 2

[0070] Add 100 grams of sodium alginate to 1 liter of purified water at 50-60° C. and stir to form a uniform aqueous solution, and stir until dispersed. Gradually add 200 grams of ground phosphatidylserine roughened product (containing 50 parts of phosphatidylserine), fully stir and homogenize. Another 1 liter of purified water at a temperature of 50-60° C. is used to fully soak and swell the chitosan at a concentration of 0.5%. The above-mentioned sodium alginate solution and chitosan solution are combined and fully stirred to form a cystic solution. Purified water (V / V, 1:2) was added to the cyst-forming solution, and about 100ml of 0.25M CaCl 2 As a curing agent, lower the temperature and control the temperature at 10°C to 15°C. Forms microcapsules of phosphatidylserine. The microcapsules were collected by filtration, washed with water, dehydrated with absolute ethanol, dried, and set aside.

Embodiment 3

[0072] Mix and grind 50 grams of gum arabic and 200 grams of phosphatidylserine roughened product (containing 40 parts of phosphatidylserine). Add to 1 liter of purified water at 50-60°C and stir to form a homogeneous aqueous solution. Another 1 liter of purified aqueous solution of 5% gelatin at a temperature of 50-60° C. was prepared. Stir constantly in a constant temperature water bath to swell completely. The above-mentioned gum arabic solution and gelatin solution are combined and stirred thoroughly to form a cystic solution. Purified water (V / V, 1:3) was added to the cyst-forming solution, and an appropriate amount of 5% dilute acetic acid was used to adjust the pH range to 4.1-4.5; the stirring was continued for 1 hour. The solution was adjusted to pH 8-9 with 20% sodium hydroxide. About 50ml of 30% formaldehyde solution is used as a curing agent, the temperature is lowered and cured, and the temperature is controlled at 10°C to 15°C to form microcapsules of phosphat...

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Abstract

The invention relates to a stable preparation of phosphatidylserine and a preparation method, application as well as an application product of the stable preparation. The preparation method comprises the following step of processing the phosphatidylserine through microencapsulation, micro-pelletization or liposome encapsulation. The stable preparation of the phosphatidylserine can be independently applied as a medicine or can be added into daily foods, drinks and health-care products, also has an important effect on health care of brains while guaranteeing the color and the taste of the daily foods and the drinks of people and is of great benefit to brain disorder such as nutritional supplement of brain development of students, overstrain of nerves of the adults, and memory loss, brain atrophy and senile dementia of the middle aged and elderly people.

Description

technical field [0001] The invention relates to the technical field of biomedicine and food processing, more specifically, to a stable preparation of phosphatidylserine, its preparation method, application and application product. Background technique [0002] Phosphatidylserine (English name Phosphatidylserine, referred to as PS), is one of the basic phospholipids that constitute the nerve tissue cells in the human body. Half of the phosphatidylserine in the human body is in the brain, which is called "the nutrient of the brain" and plays an important role in maintaining normal brain and nerve functions. With age, the amount of phosphatidylserine in the human body will gradually decrease, and its biological activity will continue to decrease, which is also one of the main reasons for the appearance of senile brain dysfunction. Over time, there will be a series of brain function disorders including memory loss, brain atrophy, and Alzheimer's disease. [0003] Phosphatidyls...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/127A61K9/16A61K31/685A61P25/00A61P3/02A23L1/29A23L33/00
Inventor 张孝友陈文良
Owner 连平劲创生物技术有限公司
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