Preparation method of anti-adhesion absorbable hernia patch

Abstract

The invention relates to a preparation method of an anti-adhesion absorbable hernia patch. The preparation method adopts a two-step spinning method and includes first degrading a polycaprolactone (PCL) fiber layer with long period as a support base layer in electrospinning mode, then degrading a poly lactic-co-glycolic acid (PLGA) fibrous membrane as a function layer in electrospinning mode and reasonably selecting a solvent in the PLGA electrospinning process to obtain a double-layer fibrous membrane material with a double-layer fibrous membrane firmly. The fibrous membrane material prepared by the method combines excellent dynamic performance of PCL and histocompatibility of PLGA and can be widely used in the hernia repair technology.

Description

Technical field:

[0001] The invention relates to the field of degradable polymer materials and composite materials, in particular to a preparation method of an anti-adhesion absorbable hernia patch. Background technique:

[0002] At present, almost all hernia repair operations will implant hernia mesh material for treatment. With the progress and development of materials, more and more materials have been designed and developed for hernia repair. From non-degradable e-PTFE and polypropylene, to partially degradable polypropylene-polyester composites, and fully degradable polyester, as well as biofilms extracted from animals that have basically no immune rejection, etc. . Although there are so many types of hernia mesh, clinical research statistics have found that there are still many problems in the performance of the current hernia mesh, such as the occurrence of postoperative infection and secondary infection, postoperative adhesion, foreign body sensation, etc. . Ther...