Preparation method of anti-adhesion absorbable hernia patch

An anti-adhesion and hernia technology, applied in medical science, prosthesis, surgery, etc., can solve rare problems and achieve excellent mechanical properties

Inactive Publication Date: 2013-02-06
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been many reports on the breakthrough of electrospinning technology in recent decades, however, there are few examples of using this technology for practical production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prepare an anti-adhesion absorbable hernia mesh as follows:

[0025] (1) Preparation of solution: Dissolve PCL (molecular weight 80000) in trifluoroethanol to prepare an electrospinning solution with a PCL concentration of 10 wt %; dissolve PLGA (molecular weight 60000), PCL (molecular weight 60000) and metronidazole in In DMF, be prepared into the electrospinning solution that concentration is 40wt%, wherein PLGA: PCL=85: 15, PLGA: metronidazole=100: 5;

[0026] (2) Spinning support base: the PCL solution obtained in (1) is placed in the feed injector of the multi-spinneret electrospinning machine, the temperature of the spinning environment is controlled to be 25 ° C, and the temperature between the spinneret and the roller is adjusted. The distance is 7-15cm, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn on the high-voltage power supply and the feeding syringe pump, adjust the voltage to 10-35KV, and the feeding speed of the solution ...

Embodiment 2

[0029] Prepare an anti-adhesion absorbable hernia mesh as follows:

[0030] (1) Preparation of solution: PCL (molecular weight 150000) is dissolved in the mixed solvent of DMF and acetone (volume ratio is 8: 2), is mixed with the electrospinning solution that PCL concentration is 15wt%; PLGA (molecular weight 80000), PLA-b-PEG (molecular weight 80,000), metronidazole, and 6-aminocaproic acid were dissolved in DMF to prepare a concentration of 35 wt% electrospinning solution, wherein PLGA:PLA-b-PEG=90:10, PLGA: Metronidazole: 6-aminocaproic acid = 100: 2: 2;

[0031] (2) Spinning support base: the PCL solution obtained in (1) is placed in the feed injector of the multi-spinneret electrospinning machine, the temperature of the spinning environment is controlled to be 25 ° C, and the temperature between the spinneret and the roller is adjusted. The distance is 7-15cm, and the air velocity in the environment is controlled at 0.5-0.8m 3 / hr; Turn on the high-voltage power supply ...

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Abstract

The invention relates to a preparation method of an anti-adhesion absorbable hernia patch. The preparation method adopts a two-step spinning method and includes first degrading a polycaprolactone (PCL) fiber layer with long period as a support base layer in electrospinning mode, then degrading a poly lactic-co-glycolic acid (PLGA) fibrous membrane as a function layer in electrospinning mode and reasonably selecting a solvent in the PLGA electrospinning process to obtain a double-layer fibrous membrane material with a double-layer fibrous membrane firmly. The fibrous membrane material prepared by the method combines excellent dynamic performance of PCL and histocompatibility of PLGA and can be widely used in the hernia repair technology.

Description

Technical field: [0001] The invention relates to the field of degradable polymer materials and composite materials, in particular to a preparation method of an anti-adhesion absorbable hernia patch. Background technique: [0002] At present, almost all hernia repair operations will implant hernia mesh material for treatment. With the progress and development of materials, more and more materials have been designed and developed for hernia repair. From non-degradable e-PTFE and polypropylene, to partially degradable polypropylene-polyester composites, and fully degradable polyester, as well as biofilms extracted from animals that have basically no immune rejection, etc. . Although there are so many types of hernia mesh, clinical research statistics have found that there are still many problems in the performance of the current hernia mesh, such as the occurrence of postoperative infection and secondary infection, postoperative adhesion, foreign body sensation, etc. . Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L27/44A61L31/14
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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