Application of hexahydric cyclic carbonate in biodegradable materials

A biodegradable material, cyclic carbonate technology, applied in the field of medical polymer materials, can solve problems such as side reactions

Active Publication Date: 2013-02-06
杨立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned methods will have some side reactions during the reaction process,

Method used

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  • Application of hexahydric cyclic carbonate in biodegradable materials
  • Application of hexahydric cyclic carbonate in biodegradable materials
  • Application of hexahydric cyclic carbonate in biodegradable materials

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1 Preparation of 5,5'-oxydimethylenebis(5-ethyl-1,3-dioxan-2-one)

[0029] The reaction equation is

[0030]

[0031] 22.5 g (0.09 mol) of bis(trimethylolpropane), 57.0 g (0.53 mol) of ethyl chloroformate and 600 ml of tetrahydrofuran were mixed in a 1000 ml three-necked flask. The three-necked flask was placed in an ice-salt bath, and stirring was started to stabilize the temperature at -10°C. 56.0g (0.55mol) triethylamine and 100ml tetrahydrofuran were placed in a constant pressure titration funnel, and slowly added dropwise to the three-necked flask at -10°C, ensuring that the temperature did not exceed 0°C during the dropwise addition. After the dropwise addition, the temperature was naturally raised to room temperature, and the reaction was continued for 12-24 h. After completion of the reaction, suction filtration with a 1000ml suction filter bottle to generate triethylamine salt by filtration, the filtrate is concentrated by rotary evaporation and th...

Example Embodiment

[0032] Example 2 Preparation of 5,5'-oxydimethylene bis(5-ethyltrimethylene carbonate) homopolymeric cross-linked product

[0033] Under anhydrous and oxygen-free conditions, 0.1 mol of 5,5'-oxydimethylene bis(5-ethyltrimethylene carbonate) was added to the polymerization tube, and stannous octoate was added after decompression and vacuuming for 3 times. (The molar ratio of monomer to stannous octoate is 5000:1), evacuated under reduced pressure for 3 times (vacuum degree<15Pa), and sealed the tube under vacuum condition. Bulk polymerization was carried out at 130° C. for 24 h to obtain a homopolymerized cross-linking product of the cross-linking agent.

Example Embodiment

[0034] Example 3 Cross-linking polymerization of 5,5'-oxydimethylene bis(5-ethyl-1,3-dioxan-2-one) and trimethylene carbonate

[0035] For the reaction equation see figure 2 . Under anhydrous and anaerobic conditions, 0.2mol trimethylene carbonate and 5×10 -5 mol5,5'-oxydimethylene bis(5-ethyl-1,3-dioxane-2-one) was added into the polymerization tube, and stannous octoate ( The ratio of the total number of moles of trimethylene carbonate and crosslinking agent to the moles of stannous octoate is 5000:1), evacuated under reduced pressure for 3 times (vacuum degree<15Pa), and sealed under vacuum conditions. Polymerization at 130 °C for 24 h to obtain cross-linking of 5,5'-oxydimethylenebis(5-ethyl-1,3-dioxan-2-one) with trimethylene carbonate polymer.

[0036] By adjusting the amount of 5,5'-oxydimethylenebis(5-ethyl-1,3-dioxan-2-one) used, crosslinked polymers with different degrees of crosslinking can be obtained.

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Abstract

The invention relates to application of a hexahydric cyclic carbonate in biodegradable materials, belonging to the field of medical high polymer materials. The invention provides application of a hexahydric cyclic carbonate in biodegradable materials. The hexahydric cyclic carbonate is 5,5'-oxybis(methylene)bis(5-ethyl-1,3-dio-xan-2-one). The 5,5'-oxybis(methylene)bis(5-ethyl-1,3-dio-xan-2-one) can be self-crosslinked or crosslinked with any other aliphatic cyclic ester monomer to obtain a crosslinked polymer; and the obtained crosslinked polymer can be used as a biodegradable material.

Description

Technical field: [0001] The invention belongs to the field of medical polymer materials, and more particularly relates to the application of a six-membered cyclic carbonate in biodegradable materials. Background technique: [0002] Biodegradable linear polyester biomaterials have always been one of the hotspots in the field of medical materials due to their excellent biocompatibility and biodegradability, such as polytrimethylene carbonate, polycaprolactone, polyethylene glycol Esters, polylactide and its copolymers, etc., have been widely used in tissue engineering repair, drug release, surgical sutures, etc. Although biodegradable linear polyester can be degraded into small molecular compounds in the body and absorbed by the body, avoiding the trouble of secondary surgical removal. However, the lack of sufficient structural stability hinders or limits their application in many fields, for example, biodegradable linear polyesters are not suitable as drug carriers for long-...

Claims

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Application Information

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IPC IPC(8): C08G64/30C08G63/664C08G69/40
Inventor 杨立群顾忠伟李建新关艳敏杨丹孟舒
Owner 杨立群
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