Process for preparing effective components of schisandrachinensis

A preparation process and technology of effective parts, applied in the field of continuous preparation of schisandra lignans, can solve the problems of unclear health effects, crossed effective parts, low extraction efficiency, etc., to improve human immunity, improve sleep, and avoid waste of resources Effect

Active Publication Date: 2014-05-07
SHENYANG PHARMA UNIVERSITY
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Problems solved by technology

[0004] In view of the above problems in the development of Schisandra chinensis, we have continuously prepared different effective parts of Schisandra chinensis, which can meet the needs of developing health care products or medicines with schisandra lignans, polyphenols, organic acids, and polysaccharides, prepared by this technology The effective parts of the product have the advantages of clear health care purpose, little crossover between effective parts, and the problem of solvent residue caused by extraction with toxic solvents can be avoided, and the waste of resources in the extraction process of Schisandra chinensis is solved to a large extent, and the extraction efficiency is low. The health benefits are not clear, and there are problems such as crossover of effective parts

Method used

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  • Process for preparing effective components of schisandrachinensis
  • Process for preparing effective components of schisandrachinensis

Examples

Experimental program
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Effect test

Embodiment 1

[0015] The dried mature fruit of Schisandra chinensis was crushed to 50 mesh, placed in supercritical CO 2 In the extraction device, the pressure of the extraction kettle: 35MPa, the temperature: 45°C, the flow rate: 8L / min; the pressure of the separation kettle: 4.5MPa, the temperature: 30°C, and the extraction was carried out for 6 hours to obtain supercritical oil of Schisandra chinensis, and the yield of the oil was 14.2 %. This part mainly contains unsaturated fatty acids, lignans and volatile oil components; the determination conditions of lignans are reversed high performance liquid chromatography, and the chromatographic conditions are acetonitrile / water gradient elution (see Table 1 for details), and the flow rate is: 1.0ml / min, column temperature 30℃, chromatographic column: PLATISIL ODS column (250mm×4.6mm, 5μm); detection wavelength 250nm, the standard used is schisandrin A, schisandrin A and schisandrin B, three kinds of oil The sum of the component contents is 1...

example 2

[0023] (1) Grind the dried and mature fruits of Schisandra chinensis to 40 mesh, and place them in supercritical CO 2 In the extraction device, the pressure of the extraction kettle: 25MPa, the temperature: 35℃, the flow rate: 4L / min; the pressure of the separation kettle: 3MPa, the temperature: 25℃, and the extraction was performed for 2 hours to obtain supercritical oil of Schisandra chinensis, which mainly contained unsaturated Fatty acid, lignan and volatile oil components, its content determination method is the same as example 1, and the chromatogram sees figure 1 (b), the results showed that the oil yield was 8.25%, and the sum of the three lignan contents was 12.1%.

[0024] (2) Add 5 times the amount of 30% ethanol to the dry residue at 25°C, stir and extract once, each extraction time: 4 hours, then filter with 6 layers of gauze, suction filter the filtrate, and extract the obtained clear filtrate Concentrate under reduced pressure to make a thick extract, dry the t...

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Abstract

The invention relates to a comprehensive process for preparing various effective components of schisandrachinensis. The preparation process is simple and concrete and can avoid phenomena of resource waste, effective component damage, unclear treating and health-caring purpose of the product and the like which are general in the conventional extracting method. According to the comprehensive technology, various effective components of the schisandrachinensis are respectively prepared, therefore, the comprehensive technology has an important application prospect on comprehensive development of schisandrachinensis healthcare product and medicine.

Description

technical field [0001] The invention relates to a preparation process for continuously preparing schisandra lignans, polyphenols, organic acids and polysaccharides. Background technique [0002] Schisandra chinensis (S.chinensis) is a perennial woody vine medicinal plant of Magnoliaceae, and its medicinal parts are dry mature fruits. Among them, the quality of Schisandra produced in Liaoning Province is the best. It is commonly called "Northern Wuwei" or "Liao Wuwei". The effect of replenishing qi and promoting body fluid, tonifying kidney and calming heart. It contains lignans, polyphenols, organic acids, unsaturated fatty acids and polysaccharides. Modern pharmacological research results show that lignans have strong liver protection, sleep improvement and anti-senile dementia effects; polyphenolic compounds are mainly anthocyanins, have strong antioxidant activity, and have a natural red color; Organic acids are mainly malic acid, maleic acid and citric acid, which are ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/57C08B37/00A61P1/16A61P25/20A61P25/28A61P39/06A61P1/14A61P37/04A23L1/30
CPCY02P20/54
Inventor 贾景明胡高升韩志福
Owner SHENYANG PHARMA UNIVERSITY
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