Process for extracting oxyresveratrol from mulberry twigs

A technology for oxidizing stilbene triphenols and mulberry branches, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of polluting the environment, resource value not being well developed, etc., and achieves a simple and suitable preparation process. Mass-produced, easy-to-handle effects

Inactive Publication Date: 2013-02-27
SUZHOU POLYTECHNIC INST OF AGRI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the traditional sericulture production, a small part is used as fuel, and most of the mulberry branches are discarded, not only the resource value has not been well developed, but also polluted the environment

Method used

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  • Process for extracting oxyresveratrol from mulberry twigs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for extracting oxystilbene from mulberry branches, which comprises the following steps carried out in sequence:

[0028] (1) Mulberry branches (Hunan, Huanglutou old branches, oxystilbene triphenol content 1.1‰) were dried in the shade (moisture content 10%), weighed 500kg of powder after crushing and sieving (40 mesh), 70% Extract with ethanol-water solution at room temperature for 3 times (4000L×1, 2500L×2, 12hr×3, solution circulation / stirring for 10min every 2hr), combine the 3 ethanol extracts, concentrate under vacuum at 55℃ to 100L fluid.

[0029] (2) After degreasing the 100L fluid obtained in step (1) with petroleum ether, extract it three times with ethyl acetate (100L×3), combine the three ethyl acetate extracts, and recover the solvent under vacuum to obtain a fluid substance, 30 After vacuum drying at ℃, 4.7 kg of solid powder was obtained, and the content of oxystilbene triphenol was measured to be 11.3%.

[0030] (3) Add 4.7 kg of the solid powd...

Embodiment 2

[0033] A method for extracting oxystilberol from mulberry branches, which is basically the same as in Example 1, except that the elution in steps (3) and (4) is isocratic segmental elution, with a concentration of 10% The difference is an interval section, the elution volume of each section is 2 column volumes, and the eluent flow rate is 1 column volume / hour. Finally, 510 g of oxystilbene triphenol crystals were obtained, and the content of oxystilbene triphenols was 96.97% as detected by HPLC.

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Abstract

The invention relates to a process for extracting oxyresveratrol from mulberry twigs which serve as raw materials. The process comprises the steps of (1) extracting mulberry twigs by using an alcohol-water solution to obtain crude extracts; (2) conducting degreasing treatment on crude extracts to obtain semi-finished products; (3) dissolving semi-finished products with an alcohol-water solution to produce a loading solution with the turbidity lower than 0.5 degree, using a macroporous resin D101 separation column, conducting wet method loading, standing till resin reaches adsorption equilibrium, conducting gradient elution or isocratic sectional elution with the alcohol-water solution serving as an elution solution, collecting the elution solution with the oxyresveratrol mass fraction larger than 40%, combining, concentrating, and drying to obtain crude products; and (4) repeating purification in Step (3) for crude products, collecting the elution solution with the oxyresveratrol mass fraction larger than or equal to 96.97%, combining, concentrating, and drying to obtain the oxyresveratrol. By the aid of the process, the oxyresveratrol can be extracted from mulberry twigs efficiently, and the process is simple to operate, low in cost and applicable to large-scale production.

Description

technical field [0001] The invention discloses a method for extracting oxystilbene triphenol from mulberry branches. Background technique [0002] Oxystilberol is an iridoid glucoside, which has a variety of beneficial biological activities: such as tyrosinase inhibitory activity, fruit and vegetable antiseptic antibacterial activity, anti-herpes simplex virus activity, anti-varicella zoster virus activity and Anti-AIDS virus and other activities, but also has anti-inflammatory, anti-inflammatory, anti-oxidation, anti-apoptosis and neuroprotective effects. [0003] Mulberry branches are the twigs of the Moraceae plant mulberry, and mulberry branches account for about 64% of the annual dry matter of mulberry gardens, and are the substances with the highest proportion of biomass in sericulture resources. However, in the traditional sericulture production, a small part is used as fuel, and most of the mulberry branches are discarded. Not only the value of its resources has not...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/21C07C37/70
Inventor 余雁
Owner SUZHOU POLYTECHNIC INST OF AGRI
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