Preparation method of polylactic-acid hollow fiber dialysis membrane

A technology of polylactic acid and dialysis membrane, applied in semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of poor biocompatibility, environmental pollution, non-biodegradable, etc., and reduce the mortality rate of dialysis , Good removal effect, less protein adsorption effect

Active Publication Date: 2013-03-13
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the membrane materials used in the above patents are all petroleum-based synthetic polymers, which have poor biocompatibility, are not biodegradable, and post-processing will cause environmental pollution.
There is no patent report on the preparation of polylactic acid hemodialysis membrane material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step (1). Add 10g of polylactic acid and 0.5g of polyvinylpyrrolidone to 89.5g of N-methylpyrrolidone, stir at 40°C for 30 hours, fully dissolve, and obtain a uniformly mixed spinning solution;

[0036] Step (2). Filter and defoam the homogeneously mixed spinning solution at 50°C and under negative pressure, and let it stand for 6 hours; keep the temperature of the defoamed spinning solution constant and pass it through at an extrusion speed of 0.1mL / min The outer channel of the spinneret with a diameter of 0.3 mm, the temperature of 25 ° C deionized water as the core fluid, the flow rate of 0.1 mL / min through the inner channel of the spinneret with a diameter of 0.2 mm, and the inner and outer channels of the spinneret The core liquid and the spinning liquid after defoaming are extruded to obtain the primary fiber;

[0037] Step (3). The nascent fibers are directly entered into a coagulation bath at 25° C. for solidification to form nascent polylactic acid hollow fiber...

Embodiment 2

[0041] Step (1). Add 25g of polylactic acid, 10g of polyethylene glycol, 5g of polycaprolactone and 5g of graphene into 55g of dimethyl sulfoxide, stir at 50°C for 28 hours, fully dissolve, and obtain a well-mixed spinning silk liquid;

[0042] Step (2). Filter and defoam the homogeneously mixed spinning solution at 52°C and under negative pressure, and let it stand for 8 hours; the spinning solution after defoaming keeps the temperature constant and passes through the diameter at an extrusion speed of 1mL / min. The outer channel of the spinneret with a diameter of 0.4mm, the core liquid at a temperature of 30°C passes through the inner channel of a spinneret with a diameter of 0.3mm at a flow rate of 1mL / min, and the core liquid and desorbent in the inner and outer channels of the spinneret The foamed spinning solution is extruded to obtain primary fibers;

[0043] The core liquid is a mixture of deionized water and ethanol, and the mass percentage of deionized water in the c...

Embodiment 3

[0048] Step (1). Add 15g of polylactic acid, 5g of glycerin, 5g of polymethyl methacrylate and 5g of silicon dioxide into 70g of dimethylacetamide, stir at 60°C for 26 hours, fully dissolve, and obtain a well-mixed spinning silk liquid;

[0049] Step (2). Filter and defoam the homogeneously mixed spinning solution at 55°C and under negative pressure, and let it stand for 9 hours; the spinning solution after defoaming keeps the temperature constant and passes through the diameter at an extrusion speed of 2mL / min. The outer channel of the spinneret is 0.8mm, and the core liquid with a temperature of 38°C passes through the inner channel of the spinneret with a diameter of 0.6mm at a flow rate of 5mL / min, and the core liquid in the inner and outer channels of the spinneret and the defoamed The spinning solution is extruded to obtain primary fibers;

[0050] The core liquid is a mixture of deionized water and dimethyl sulfoxide, and the mass percentage of deionized water in the c...

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Abstract

The invention relates to a preparation method of a polylactic-acid hollow fiber dialysis membrane, which aims to overcome the defects that the conventional dialysis membrane material is poor in biocompatibility and easy to cause environmental pollution. The preparation method comprises the following steps of: adding polylactic acid, a pore-forming agent, a toughening agent and an inorganic filler to a solvent, stirring the components at 40-120 DEG C for 8-12 hours to obtain a spinning solution, and then deforming the spinning solution; carrying out extrusion moulding on the defoamed spinning solution and core liquid which respectively pass through an external channel and an inner channel of a spinning nozzle, thus obtaining nascent fibers; curing the nascent fibers in coagulating bath after the nascent fibers pass through air gaps of 0 to 50cm, thus forming a nascent polylactic-acid hollow fiber membrane; collecting the nascent polylactic-acid hollow fiber membrane by a coiler at a speed of 1-30 m / min, thus obtaining the polylactic-acid hollow fiber membrane; and finally soaking the membrane in circulating deionized water at 20-45 DEG C for 6 to 48 hours, and taking out and drying the membrane. The preparation method has the advantages of little pollution and energy conservation; and the prepared dialysis membrane is good in biocompatibility and low in adsorption capacity of proteins, has a good elimination effect on urotoxy matters, and is biodegradable.

Description

technical field [0001] The invention belongs to the technical field of polymer material dialysis membranes, and in particular relates to a preparation method of polylactic acid hollow fiber dialysis membranes. technical background [0002] In the early 19th century, John Abel of the Johns Hopkins School of Medicine in the United States and his colleagues first used collodion to make a tubular dialyzer and named it an artificial kidney. The dialyzer was placed in normal saline, and hirudin was used as an anticoagulant to perform hemodialysis on rabbits for 2 hours, and satisfactory results were obtained, thus creating a hemodialysis business. Subsequently, the United States and European countries successively carried out research on dialysis, especially after the First World War, many patients with acute renal failure caused by war injuries required dialysis treatment, which promoted the development of artificial kidneys. The shape of the dialyzer successively went through t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/48B01D69/08B01D67/00
Inventor 刘富薛立新高爱林
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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