Cataplasm substrate and application thereof

A poultice and matrix technology, which is applied to the poultice matrix and its application field, can solve the problems of poor sticking property, insufficient viscoelasticity, easy slipping and the like, and achieves fast onset of medicinal properties, good compliance, Use good effect

Active Publication Date: 2013-03-20
HENAN LINGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, in order to solve the defects of the prior art, the object of the present invention is to provide a cataplasm matrix and its application, which can effectively solve the problems of insufficient viscoelasticity, poor applicability, and easy slipping of the applicator in the prior art.

Method used

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  • Cataplasm substrate and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] When the present invention is implemented, it can be calculated by the following weight percentages: polyacrylic acid 4.2%, sodium carboxymethyl cellulose 4%, polyvinylpyrrolidone 4%, polyethylene oxide 1.5%, glycerin 26%, purified water 58.5%, glycerin Aluminum hydroxyaluminum 0.1%, disodium edetate 0.15%, tartaric acid 0.15%, crospovidone 1% and Genma BP 0.4%, among them, (1) sodium carboxymethyl cellulose, poly Add vinylpyrrolidone and polyethylene oxide into purified water and heat to dissolve, then add tartaric acid and Genma BP, mix and stir to form a water phase, and set aside; The polyvidone is mixed and stirred evenly to form an oil phase, and the water phase and the oil phase are mixed together, and stirred evenly to obtain the product.

[0014] Also by weight: 420g polyacrylic acid, 400g sodium carboxymethylcellulose, 400g polyvinylpyrrolidone, 150g polyethylene oxide, 2600g glycerin, 5850g purified water, 10g aluminum glycolate, 15g disodium edetate, tartari...

Embodiment 2

[0016] When the present invention is implemented, it is calculated by the following percentages by weight: 4.8% polyacrylic acid, 2.5% sodium carboxymethyl cellulose, 4% polyvinylpyrrolidone, 30% glycerin, 55.79% purified water, 0.06% aluminum glycylate, hydrogen Made of 0.4% alumina, 0.1% ethylenediaminetetraacetic acid, 0.2% tartaric acid, 2% silicon dioxide and 0.15% jalandan, among which, (1) first add sodium carboxymethylcellulose and polyvinylpyrrolidone to purify Heat to dissolve in water, then add tartaric acid and galadan, mix and stir evenly to form a water phase, and set aside; (2) Mix glycerin, polyacrylic acid, aluminum glycolate, aluminum hydroxide, ethylenediaminetetraacetic acid and silicon dioxide For the oil phase, mix the water phase and the oil phase together, stir evenly, and you get it.

[0017] Also by weight: 480g polyacrylic acid, 250g sodium carboxymethylcellulose, 400g polyvinylpyrrolidone, 3000g glycerin, 5579g purified water, 6g aluminum gl...

Embodiment 3

[0019] When the present invention is implemented, it is calculated by the following weight percentages: polyacrylic acid 8%, gelatin 3.2%, carbomer 2%, propylene glycol 30%, purified water 54.37%, aluminum chloride 0.3%, ethylenediaminetetraacetic acid tetra 0.18% sodium, 0.25% citric acid, 1.5% sodium carboxymethylcellulose and 0.2% methyl paraben, among which (1) add gelatin and carbomer to purified water and heat to dissolve, then add citric acid , methyl paraben and stir evenly to form a water phase, and set aside; (2) Mix propylene glycol, polyacrylic acid, aluminum chloride, tetrasodium edetate and sodium carboxymethylcellulose to form an oil phase, and The water phase and the oil phase are mixed together and stirred evenly, that is to say.

[0020] Also by weight: 800g polyacrylic acid, 320g gelatin, 200g carbomer, 3000g propylene glycol, 5437g purified water, 30g aluminum chloride, 18g tetrasodium edetate, 25g citric acid, 150g sodium carboxymethyl cellulose Made ...

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Abstract

The invention relates to a cataplasm substrate and application thereof. The cataplasm substrate can effectively solve the problems of insufficient viscoelasticity, bad adhesion and easiness for adhesion dropping in the prior art. The cataplasm substrate is prepared from the following materials in percentage by weight: 4%-8% of polyacrylic acid, 5%-10% of tackifiers, 25%-35% of humectants, 40%-65% of purified water, 0.05%-0.5% of cross-linking agents, 0.05%-0.2% of cross-linking regulating agents, 0.1%-0.5% of pH regulating agents, 0.5%-10% of filling agents and 0.01%-0.5% of antiseptics and through the following steps of: firstly dissolving the tackifiers by using the purified water, then adding the pH regulating agents and the antiseptics and mixing and stirring to obtain a uniform water phase for standby; then mixing the polyacrylic acid, the humectants, the cross-linking agents, the cross-linking regulating agents and the filling agents, and stirring to obtain a uniform oil phase; and then mixing the water phase and the oil phase together, uniformly stirring to obtain the cataplasm substrate. The cataplasm substrate disclosed by the invention has the advantages of good dependence on skin, no stimulation, quick medical effect, repeated viscosity, moisture preservation and air ventilation and good using effect and is an innovation of the cataplasm substrate.

Description

technical field [0001] The invention relates to medicine, in particular to a cataplasm matrix and its application. Background technique [0002] Catapult refers to the plaster made by mixing the extracts of medicinal materials, medicinal materials or chemical drugs with a suitable hydrophilic matrix, and then coating them on the backing material. As early as 1963, Saitama Daiichi Pharmaceutical Co., Ltd. took the lead in inventing the dosage form of catarrh and launching related products. In 1999, "Compound Zijing Xiaoshang Ointment" obtained the first new drug certificate for cataplasm in China. [0003] Compared with traditional plasters, cataplasms have the advantages of large drug loading, good transdermal effect, high bioavailability, controllable dosage and components, strong moisture retention, good compatibility with skin, and no organic solvent pollution. , In addition, the cataplasm base contains moisturizing ingredients such as water, glycerin, and sorbitol, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K47/38A61K47/36A61K47/34A61K47/32
Inventor 熊维政程剑军江开勇武惠斌杨义厚卢玉斌李磊郑志鹏吕平黄燕琴李绪栋马正伟
Owner HENAN LINGRUI PHARMA
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