37results about How to "Fast onset of action" patented technology

The invention relates to a cataplasm substrate and application thereof. The cataplasm substrate can effectively solve the problems of insufficient viscoelasticity, bad adhesion and easiness for adhesion dropping in the prior art. The cataplasm substrate is prepared from the following materials in percentage by weight: 4%-8% of polyacrylic acid, 5%-10% of tackifiers, 25%-35% of humectants, 40%-65% of purified water, 0.05%-0.5% of cross-linking agents, 0.05%-0.2% of cross-linking regulating agents, 0.1%-0.5% of pH regulating agents, 0.5%-10% of filling agents and 0.01%-0.5% of antiseptics and through the following steps of: firstly dissolving the tackifiers by using the purified water, then adding the pH regulating agents and the antiseptics and mixing and stirring to obtain a uniform water phase for standby; then mixing the polyacrylic acid, the humectants, the cross-linking agents, the cross-linking regulating agents and the filling agents, and stirring to obtain a uniform oil phase; and then mixing the water phase and the oil phase together, uniformly stirring to obtain the cataplasm substrate. The cataplasm substrate disclosed by the invention has the advantages of good dependence on skin, no stimulation, quick medical effect, repeated viscosity, moisture preservation and air ventilation and good using effect and is an innovation of the cataplasm substrate.

The invention discloses a rapid hemostatic product for war wounds, as well as a preparation method and application thereof. The rapid hemostatic product comprises a substrate with added microbial transglutaminase (mTG), wherein the amino acid sequence of the transglutaminase is the protein sequence coded by the gene shown in SEQ ID NO.: 3, or a protein sequence shown in SEQ ID NO.: 4. More specifically, the rapid hemostatic product is selected from a hemostatic agent, a hemostatic device, a hemostatic first-aid kit or a common hemostatic product, the substrate is in a fluid or semi-solid form, which can be absorbed by a human body, or in a malleable gel or colloid form, and the rapid hemostatic product contains the microbial transglutaminase and gelatin. The rapid hemostatic product has the advantages of rapid hemostasis, convenience for use, organ adhesion prevention, wound healing promotion, low toxic and side effects, complete absorption and the like; except for hemostasis in a war, the rapid hemostatic product can also be widely applied to rapid hemostasis for wounds in fire control, accidents and other wild environments.

The invention relates to a formula and a preparation method of a preparation delivered through a mucous membrane. The formula of the preparation delivered through the mucous membrane is characterized in that substances are mainly delivered through surfaces of oral cavity, vagina and nasal mucous membranes and one or more proteins or hydrolysis products with mucous membrane gluing or mucous membrane penetrability and one or more substances to be delivered are contained in the formula of the preparation. Compared with the prior art, the formula of the preparation delivered through the mucous membrane has the advantages that no toxicity and stimulation are produced in a using process, the preparation delivered through the mucous membrane is easy to use, and medical cost and side effect are obviously reduced, so that the preparation delivered through the mucous membrane is especially applicable to being medically and widely used.

The invention relates to ribavirin lipid microspheres of a targeting drug delivery system and a method for preparing the same, in particular to ribavirin lipid microsphere effervescent granules and a method for preparing the same. The method comprises the steps of: adopting film dispersion technology to obtain the ribavirin lipid microspheres by combining a certain amount of yolk lecithin, cholesterol and deoxysodium cholate with an active component, namely ribavirin, and then mixing the ribavirin lipid microspheres with certain excipient to obtain the effervescent granules. The effervescent granules have the advantages of quick response, high bioavailability, and less toxic and side effects, so that the satisfactory technical effect is achieved.

The invention discloses a compound injection for treating poultry viral diseases and a preparation method thereof. The compound injection comprises the following raw materials in parts by weight: 2 to 4 parts of radix astragali extract, and 6 to 8 parts of chicken alpha-interferon. The provided compound injection for treating poultry viral diseases is prepared by compounding radix astragali extract and alpha-interferon together, and thus has a faster effect and better curative effect on treating poultry viral diseases. Moreover, the injection has the advantages of no drug residue, no side or toxic effect, user-friendliness, safety, and reliability. The compound injection has the biological functions of strengthening the organism immunity, enhancing the vaccine immunity effect, and reducing the stress reactions. The compound injection can treat viral diseases, also can adjust the organism immunity and strengthen the infection resistant performance of the organism, and thus can be used to prevent poultry viral diseases and prevent and treat unknown tumor diseases.

The invention discloses a traditional Chinese medicine preparation for treating dizziness, palpitation, insomnia and forgetfulness and a preparation method of the traditional Chinese medicine preparation. The preparation is prepared from the following components in parts by weight: 80-120 parts of hairyvein agrimony, 40-80 parts of eclipta, 40-80 parts of caulis spatholobi, 40-80 parts of radix rehmanniae praeparata, 40-80 parts of radix rehmanniae, 40-80 parts of cortex albiziae, 45-75 parts of vine multiflower knotweed, 30-50 parts of sodium alginate, 10-20 parts of hydroxypropyl methyl cellulose, 20-40 parts of calcium sulfate, 20-30 parts of crosslinking polyvingypyrrolidone, 20-40 parts of glucan, 5-15 parts of sodium dodecyl sulfate and 1-3 parts of aerosil. The preparation is a dispersed tablet, and the preparation method comprises the steps of preparing dry paste powder from medicinal materials through extraction; preparing a clathrate compound from the dry paste powder; and further preparing the dispersed table from the clathrate compound. The product is capable of obviously improving the solubleness of an indissolvable drug in the medicinal material extract dry paste powder, shortening the disintegration time limit and improving the bioavailability. The preparation method is simple in process, low in production cost and low in energy consumption, and industrial production is easy to implement.

The invention discloses a traditional Chinese medicine composition for treating epidermis injury and a preparation method thereof. The composition is prepared from more than thirty traditional Chinese medicines in certain ratio and the more than thirty medicines are namely poison nut, catechu, platycodon root, radix trichosanthis, mongolian dandelion herb, lycopodium clavatum, excrementum pteropi, myrrh, herba houttuyniae, callicarpa bodinieri and the like; the preparation method comprises the following steps: smashing the raw materials, decocting and condensing the raw materials to obtain a traditional Chinese medicine extract. The traditional Chinese medicine composition provided by the invention has the functions of stimulating the circulation of the blood to relax muscles and joints, promoting blood circulation to remove blood stasis, diminishing inflammation and pain stopping and is suitable for treating pain and swelling caused by epidermis injury and repairing cells; the traditional Chinese medicine composition prepared by adopting the method can quickly repair worn epidermal cells, quickly diminish swelling and stop pain and effectively improve clinical signs and symptoms of a patient in a shorter period of time; the traditional Chinese medicine composition is small in toxic or side effects, can be directly absorbed and utilized by the skin through skin permeation, quickly takes effect, has mild taste, is suitable for people with various skin types, has no allergic response and is convenient to prepare and use and stable in curative effect.

The invention discloses an extrusion device for skin injury treatment ointment. The device comprises a shell, wherein a fixed tube is arranged in the shell; one end of the fixed tube is an outlet, and extends out of the shell; a piston is arranged in the fixed tube; a storage cavity is formed between the piston and the outlet of the fixed tube; the storage cavity is filled with a Chinese medicinal composition for treating skin injury; a piston rod is arranged on the piston; a rack is arranged at the lower end of the piston rod; a first rotating shaft and a second rotating shaft are vertically arranged in the shell; a first connecting wheel and a bevel gear are arranged on the first rotating shaft; a linkage gear is arranged on the sidewall of the shell, and is matched with the rack and the bevel gear respectively; the second rotating shaft is positioned below the outlet of the fixed tube; a second connecting wheel is arranged on the second rotating shaft, and is connected with the first connecting wheel through a transmission belt; a rotary table is arranged at the top of the second rotating shaft, and is positioned at the lower part of the outlet of the fixed tube on the outer side of the shell; an eccentric handle is arranged on the rotary table.

The invention relates to a dampness removing and parasite destroying traditional Chinese medicine composition and a preparation method thereof. The dampness removing and parasite destroying traditional Chinese medicine composition is made from, by weight, 90-120 parts of folium callicarpae formosanae, 40-70 parts of boric acid, 90-120 parts of sophora flavescens, 8-20 parts of camphor, 90-120 parts of herba agrimoniae, 8-20 parts of alumen, 90-120 parts of radix stemonae, 3-6 parts of borneol, 90-120 parts of common cnidium fruit and 4-7 parts of benzalkonium bromide. The dampness removing and parasite destroying traditional Chinese medicine composition has efficacies of heat clearing, detoxicating, parasite destroying and itching relieving and is applicable to bacterial vaginitis with downward flow of dampness and heat, colpomycosis and trichomonas vaginitis, and according to clinical observation, curative effects are obvious, and no toxic or side effect is found.

The invention discloses a rapid hemostatic product for clinical operation wounds, as well as a preparation method and application of the rapid hemostatic product. The rapid hemostatic product comprises a matrix containing a microbial transglutaminase (mT6), wherein the amino acid sequence of the transglutaminase is the protein sequence coded by the gene shown in SEQ ID NO.: 3, or the protein sequence shown in SEQ ID NO.: 4. Specifically, the rapid hemostatic product is selected from a hemostatic, a hemostatic device, a hemostatic first-aid kit or a common hemostatic product; the matrix adopts a fluid or semisolid form, which can be absorbed by a human body, or a plastic gel or colloid form. The rapid hemostatic product contains the microbial transglutaminase and gelatin. The rapid hemostatic product has the advantages of rapid hemostatic property, convenience for use, prevention on organ adhesion, promotion on wound healing, low toxic and side effects, complete absorption and the like. The rapid hemostatic product can be used as a medical hemostatic material or product for clinical operation wounds, can stop bleeding rapidly, prevents organ adhesion, is easy to absorb, has little possibility of spreading diseases, and is low in cost.

A vaginal IgY effervescent tablet specifically to kill Candida albicans for treating mycotic vaginitis of woman, even if gravida and puerpera, is disclosed.

The invention belongs to the technical field of weight reducing medicines, and provides a pharmaceutical composition with a fat reducing effect. The pharmaceutical composition with the fat reducing effect comprises a photosensitizer and rosiglitazone; the photosensitizer comprises one or a mixture of more of photoporphyrin, viltipofen, temopofen, chlorin e6, zinc phthalocyanine and 5-aminolevulinic acid; and the mass ratio of the photosensitizer to the rosiglitazone is 3: 1-10: 1. When the pharmaceutical composition is applied, the pharmaceutical composition powder is diluted and dissolved bynormal saline, and then the pharmaceutical composition is administrated in an intravenous injection mode. Photodynamic cell killing of the photosensitizer is combined with cell browning induction of the rosiglitazone, so that an optimal weight losing strategy combining 'fast and slow ' and 'local and integrity' is realized. The two drug effects are good complementary pairs, and experimental results show that the two drug effects have quite good synergistic effects. In addition, the rosiglitazone also has an obvious inhibition effect on adverse reactions possibly caused by photosensitizer treatment.

The invention provides a broad spectrum external traditional Chinese medicine preparation for skins. The preparation comprises the following components in percentage by weight: 20-56% of a cinnamomum burmannii extract, 15-30% of an asarum insigne extract, 15-25% of an extract of red psychotria leaves, 3-5% of a dye yam extract, 4-8% of eugenol, 3-4% of wintergreen oil and 4-8% of a transdermal agent. The broad spectrum external traditional Chinese medicine preparation for skins has the major functions of stopping bleeding, relieving pain and diminishing swelling, diminishing inflammation and relieving itching, eliminating putridity and engendering flesh and promoting wound healing and is suitable for blood seepage of damage outside the skins and symptoms for relieving pain and diminishing swelling, and can be further used for treating mange, skin and external diseases, unknown pyogenic infections and skin itch harmful to the skins, killing sarcoptes mites and louses, preventing mosquito bite and protecting the skins. The broad spectrum external traditional Chinese medicine preparation for skins provided by the invention changes the delivery system through merger of groups of traditional Chinese medicines integrated with the transdermal agent, so that the functions of the traditional Chinese medicines can be adequately exerted, and the use range of the preparation is expanded. The preparation has the characteristics of less dosage, good curative effect, short course and multipurpose by broad spectrum.

The invention relates to clindamycin phosphate freeze-drying powder for injection. The clindamycin phosphate freeze-drying powder for injection is prepared from the following components in parts by weight: 100 parts of clindamycin phosphate, 5 to 15 parts of sodium chloride, 2 to 6 parts of mannitol, and 10 to 30 parts of sodium hydroxide. A preparation method comprises the steps of preparing rawmaterials; preparing a medicine liquid; filtering; sub-packaging in a sterile way; vacuum freeze drying and packaging, wherein vacuum freeze drying comprises pre-freezing, one-stage drying, two-stagedrying, three-stage drying and four-stage drying. According to the clindamycin phosphate freeze-drying powder for injection provided by the invention, through adjusting and accurately controlling a product recipe, processing steps and control parameters, the stability performance of the product is further ensured; through the sufficient verification of a stability test, an acceleration test and along-term test, the clindamycin phosphate freeze-drying powder prepared by adopting the method provided by the invention is not changed in appearance, remarkably increased in related substances, and remarkably reduced in main content, so that the storage stability and the clinic application safety of the clindamycin phosphate freeze-drying powder are ensured maximally.

The invention relates to a human glucagon-like peptide-1 analogue containing medicine composition delivered via an oral mucosa. The medicine composition comprises a high-concentration glucagon-like peptide-1 analogue, hyaluronidase, and one or more mucosa absorbents, or further comprises or does not comprise one or more thickening agents. The medicine composition has excellent permeation absorbency and biological activity, and is high in bioavailability and safe and nontoxic in formula. The invention further provides a preparation method of the medicine composition, and application of the medicine composition in preparing a medicine for treating hyperglycemia and / or diabetes mellitus. The medicine composition is convenient to use, has no toxicity or stimulation in a using process, takes effect quickly, and can significantly improve clinical medication compliance of a patient.

The invention discloses a hangover soup and a preparation method thereof. The formula of the medicine and food homologous combination formula is: 5-10 grams of imperial chrysanthemum, 3-8 grams of medlar, 10-15 grams of Hovenia dulcis, and 1-5 grams of honey gram. By breaking the plant cell wall, the traditional Chinese medicinal material of the present invention can better absorb water and nutrients and maintain active ingredients, release phytochemicals, and can be fused with dietary fiber, vitamins and other influencing elements, which can be quickly absorbed by the human body, increasing The medicinal effect and accelerated absorption of Jiejiu decoction make the medicinal effect of Jiejiu decoction fast and effective; the innovative decoction process of Jiejiu decoction of the present invention, the decoction concentration obtained by decocting the same dose of medicinal materials is higher than that of the traditional method Or make it into the decoction concentration obtained by the granular method, fully bring into play the efficacy of traditional Chinese medicine, and the efficacy and effect of the medicine are good.

The invention provides a broad spectrum external traditional Chinese medicine preparation for skins. The preparation comprises the following components in percentage by weight: 20-56% of a cinnamomum burmannii extract, 15-30% of an asarum insigne extract, 15-25% of an extract of red psychotria leaves, 3-5% of a dye yam extract, 4-8% of eugenol, 3-4% of wintergreen oil and 4-8% of a transdermal agent. The broad spectrum external traditional Chinese medicine preparation for skins has the major functions of stopping bleeding, relieving pain and diminishing swelling, diminishing inflammation and relieving itching, eliminating putridity and engendering flesh and promoting wound healing and is suitable for blood seepage of damage outside the skins and symptoms for relieving pain and diminishing swelling, and can be further used for treating mange, skin and external diseases, unknown pyogenic infections and skin itch harmful to the skins, killing sarcoptes mites and louses, preventing mosquito bite and protecting the skins. The broad spectrum external traditional Chinese medicine preparation for skins provided by the invention changes the delivery system through merger of groups of traditional Chinese medicines integrated with the transdermal agent, so that the functions of the traditional Chinese medicines can be adequately exerted, and the use range of the preparation is expanded. The preparation has the characteristics of less dosage, good curative effect, short course and multipurpose by broad spectrum.

The invention discloses a traditional Chinese medicine preparation for resolving phlegm to relieve the cough and a preparation method thereof. The preparation is prepared from the following components in parts by weight: 210 to 240 parts of radix platycodonis, 100 to 130 parts of liquorice roots, 70 to 90 parts of a radix polygalae liquid extract, 0.5 to 0.8 part of menthol, 1.2 to 1.4 parts of mandarin oil, 4 to 6 parts of ephedrine hydrochloride, 45 to 65 parts of a radix stemonae liquid extract, 12 to 16 parts of beta-cyclodextrin, 40 to 60 parts of polyvinylpolypyrrolidone, 10 to 20 parts of hydroxypropyl methyl cellulose, 100 to 200 parts of pregelatinized starch, 15 to 25 parts of sodium carboxymethyl starch, 12 to 16 parts of lauryl sodium sulfate and 3 to 5 parts of superfine silica powder. The preparation is made into dispersible tablets. The preparation method of the preparation comprises the steps of preparing a thick paste from the radix platycodonis and the liquorice roots through extraction, then preparing dry paste powder from the radix polygalae liquid extract, the ephedrine hydrochloride and the radix stemonae liquid extract together with the thick paste, preparing an inclusion from the menthol and the mandarin oil, and further preparing the dispersible tablets. According to the traditional Chinese medicine preparation, the disintegration time limit can be obviously shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost and low in energy consumption, thereby being favorable for realizing industrial production.

The invention belongs to the technical field of weight-loss drugs, and provides a pharmaceutical composition with a fat-reducing effect, including a photosensitizer and rosiglitazone; wherein the photosensitizer includes photoporphyrin, verteporfin, temoporfin, One of chlorin e6, zinc phthalocyanine, and 5-aminolevulinic acid or a mixture of them; the mass ratio of the photosensitizer to rosiglitazone is 3:1-10:1. During administration, the pharmaceutical composition powder of the present invention is diluted and dissolved with physiological saline, and then administered through intravenous injection. The present invention combines the photodynamic cell killing of the photosensitizer with the browning induction of rosiglitazone to realize the optimal weight loss strategy combining "fast-slow" and "local-whole". The two drugs are a good complementary pair, and the experimental results show that they have quite good synergistic effects; in addition, rosiglitazone also has a significant inhibitory effect on the adverse reactions that may be caused by photosensitizer treatment.

The invention discloses a gynecological antipruritic tablet and a preparation method thereof. The gynecological antipruritic tablet is mainly prepared from, by weight, 435 parts of herba patriniae, 435 parts of spreading hedyotis herb, 435 parts of dandelions, 150 parts of membranaceous beautyleaf roots, 435 parts of radix rubiae, 435 parts of caulis spatholobi, 290 parts of angelica sinensis and100 parts of rhizoma corydalis (stir-baking with vinegar). The gynecological antipruritic tablet produced by the preparation method has the advantages that the disintegration speed is high, the dissolution is better, the absorption is faster, the action is fast, the bioavailability is high, the adverse reactions are few, and taking is convenient; pharmacological experiment results show that the gynecological antipruritic tablet is superior to a gynecological antipruritic tablet prepared by a traditional method in inflammation resistance, bacteriostasis and other aspects; clinical trial resultsshow that the gynecological antipruritic tablet has a better curative effect on the treatment of damp-heat type elytritis, is safe and reliable to take, and has no side effects.

A measuring and pay-off device special for an electric transmission line rod tower ground resistor comprises a base and a rotating shaft. A hinge base is mounted in the middle of the top face of the base, a connecting block is hinged to the hinge base, and the connecting block is fixedly provided with a fixing shaft. The fixing shaft is matched to be provided with a connecting sleeve, the connecting sleeve is provided with a connecting rod, and a handle is mounted at the upper end of the connecting rod. Wire coils are mounted at the two ends of the rotating shaft, a crank is mounted on the end face of the outer side of each wire coil, a shaft sleeve is mounted in the middle of the rotating shaft, and the shaft sleeve and the connecting rod are fixedly connected. The measuring and pay-off device special for the electric transmission line rod tower ground resistor has the advantages that the hinge base, the connecting sleeve and the rotating shaft are matched with all related components, take-up and pay-off operation of insulated connecting wires on the wire coils can be achieved at various angles through the cranks, and the phenomena of deformation, cracking and the like caused by winding and binding of the insulated connecting wires in the wire take-up and pay-off process can be avoided. The measuring and pay-off device special for the electric transmission line rod tower ground resistor further has the advantages of being simple and compact in structure, low in manufacturing cost and easy and convenient to use.

The invention discloses a preparation method of Yinqiao powder ultrafine powder. The Yinqiao powder ultrafine powder is prepared from 100 parts of honeysuckle flowers, 100 parts of fructus forsythiae,60 parts of radix platycodi, 60 parts of herba menthae, 50 parts of fermented soybean, 40 parts of herba lophatheri, 60 parts of fructus arctii, 40 parts of spica schizonepetae, 100 parts of rhizomaphragmitis and 40 parts of liquorice roots. The preparation method comprises the following steps of taking each kind of medical material according to the proportion; grinding the materials into 20 to100 meshes of Yinqiao powder primary powder; crushing 20 to 100 percent of the Yinqiao powder primary powder by an ultrafine crushing machine; putting the materials into the ultra-fine crushing machine to be crushed for 10 to 30min to obtain the Yinqiao powder ultrafine powder. The preparation method has the advantages that the repeated performance and the stability are good; the prepared Yinqiaopowder ultrafine powder has the small particle diameter. Compared with the conventional Yinqiao powder fine powder, the Yinqiao powder ultrafine powder has the advantages that the anti-inflammatory effect is better; the effect acting is fast; the swelling inhibition rate is improved; the half medicine dose is reduced; the dose reduction and effect enhancing effects are achieved.

The invention relates to a human parathyroid hormone containing medicine composition delivered via an oral mucosa. The medicine composition comprises high-concentration human parathyroid hormone, an absorption penetrating promoter, a mucosa absorbent, a thickening agent, a buffer solution, an antioxidant and a stabilizing agent. The medicine composition has excellent stability, permeation absorbency and biological activity and is high in bioavailability and safe and nontoxic in formula.The invention further provides a preparation method of the medicine composition, and application of the medicine composition in preparing a medicine for treating and / or preventing osteoporosis. The medicine composition is convenient to use, has no toxicity or stimulation in a using process, takes effect quickly, and can significantly improve clinical medication compliance of a patient.

The invention relates to a special health-care medicinal liquor for treatment of lumbar disc herniation and rheumatic bone diseases. The special health-care medicinal liquor mainly overcomes the problems of slow treatment effect and long treatment course of conventional drugs. The special health-care medicinal liquor is characterized by comprising, by weight, 18 to 28 parts of Cortex Illicii, 17 to 27 parts of obscured homalomena rhizomes, 15 to 25 parts of Mongolian jurinea tomentum, 500 parts of liquor and 3 to 5 parts of scorpion. The special health-care medicinal liquor of the invention has the advantages of obvious treatment effect, fast action, small possibility of recurrence, short treatment period and convenient treatment.

The present invention provides a clenbuterol aerosol inhalation solution preparation and a preparation method thereof. The clenbuterol aerosol inhalation solution preparation comprises clenbuterol, astabilizer, an osmotic pressure regulator, an appropriate amount of a pH regulator, and water. The clenbuterol aerosol inhalation solution preparation is reasonable in compositions, uses an atomized inhalation manner to conduct direct inhalation from mouth and nose, can avoid a first-pass effect of the liver and destruction and degradation of gastrointestinal tract, greatly reduces drug metabolismprocesses of the liver and kidneys, reduces organ damages to patients, is even in drug distribution, has a drug average particle diameter of about 0.2 [mu]m and a ratio of inhalable particles as highas 74% or more, is quick in taking effect, simple in the preparation method and low in cost, and has a very good development prospect.

An automatic telescopic measurement rod comprises a handle, wherein the handle is hollow, a storage battery and a motor are installed in the handle, a button for controlling on and off of the storage battery is installed on the handle, an electric telescopic rod is installed at the front end of the handle, the rear end of the handle is hinged to a baffle, an output shaft of the motor is connected with the electric telescopic rod, a digital displayer is installed on the electric telescopic rod, a displacement sensor is installed at the free end of the electric telescopic rod, the digital displayer and the displacement sensor transmit data through a transmission line, a bracket is installed at the tail end of an external pipe of the electric telescopic rod, and two limiting rollers are installed on the bracket, are located on two sides of an inner pipe of the electric telescopic rod and make contact with the inner pipe of the electric telescopic rod; the storage battery is connected with the motor, the displacement sensor and the digital displayer; the handle, the electric telescopic rod and the bracket are arranged on a base, and the base is matched with the handle and the electric telescopic rod through a supporting frame.