37results about How to "Fast onset of action" patented technology

The invention relates to a cataplasm substrate and application thereof. The cataplasm substrate can effectively solve the problems of insufficient viscoelasticity, bad adhesion and easiness for adhesion dropping in the prior art. The cataplasm substrate is prepared from the following materials in percentage by weight: 4%-8% of polyacrylic acid, 5%-10% of tackifiers, 25%-35% of humectants, 40%-65% of purified water, 0.05%-0.5% of cross-linking agents, 0.05%-0.2% of cross-linking regulating agents, 0.1%-0.5% of pH regulating agents, 0.5%-10% of filling agents and 0.01%-0.5% of antiseptics and through the following steps of: firstly dissolving the tackifiers by using the purified water, then adding the pH regulating agents and the antiseptics and mixing and stirring to obtain a uniform water phase for standby; then mixing the polyacrylic acid, the humectants, the cross-linking agents, the cross-linking regulating agents and the filling agents, and stirring to obtain a uniform oil phase; and then mixing the water phase and the oil phase together, uniformly stirring to obtain the cataplasm substrate. The cataplasm substrate disclosed by the invention has the advantages of good dependence on skin, no stimulation, quick medical effect, repeated viscosity, moisture preservation and air ventilation and good using effect and is an innovation of the cataplasm substrate.

The invention discloses a rapid hemostatic product for war wounds, as well as a preparation method and application thereof. The rapid hemostatic product comprises a substrate with added microbial transglutaminase (mTG), wherein the amino acid sequence of the transglutaminase is the protein sequence coded by the gene shown in SEQ ID NO.: 3, or a protein sequence shown in SEQ ID NO.: 4. More specifically, the rapid hemostatic product is selected from a hemostatic agent, a hemostatic device, a hemostatic first-aid kit or a common hemostatic product, the substrate is in a fluid or semi-solid form, which can be absorbed by a human body, or in a malleable gel or colloid form, and the rapid hemostatic product contains the microbial transglutaminase and gelatin. The rapid hemostatic product has the advantages of rapid hemostasis, convenience for use, organ adhesion prevention, wound healing promotion, low toxic and side effects, complete absorption and the like; except for hemostasis in a war, the rapid hemostatic product can also be widely applied to rapid hemostasis for wounds in fire control, accidents and other wild environments.

The invention relates to a formula and a preparation method of a preparation delivered through a mucous membrane. The formula of the preparation delivered through the mucous membrane is characterized in that substances are mainly delivered through surfaces of oral cavity, vagina and nasal mucous membranes and one or more proteins or hydrolysis products with mucous membrane gluing or mucous membrane penetrability and one or more substances to be delivered are contained in the formula of the preparation. Compared with the prior art, the formula of the preparation delivered through the mucous membrane has the advantages that no toxicity and stimulation are produced in a using process, the preparation delivered through the mucous membrane is easy to use, and medical cost and side effect are obviously reduced, so that the preparation delivered through the mucous membrane is especially applicable to being medically and widely used.

The invention relates to ribavirin lipid microspheres of a targeting drug delivery system and a method for preparing the same, in particular to ribavirin lipid microsphere effervescent granules and a method for preparing the same. The method comprises the steps of: adopting film dispersion technology to obtain the ribavirin lipid microspheres by combining a certain amount of yolk lecithin, cholesterol and deoxysodium cholate with an active component, namely ribavirin, and then mixing the ribavirin lipid microspheres with certain excipient to obtain the effervescent granules. The effervescent granules have the advantages of quick response, high bioavailability, and less toxic and side effects, so that the satisfactory technical effect is achieved.

The invention relates to a dampness removing and parasite destroying traditional Chinese medicine composition and a preparation method thereof. The dampness removing and parasite destroying traditional Chinese medicine composition is made from, by weight, 90-120 parts of folium callicarpae formosanae, 40-70 parts of boric acid, 90-120 parts of sophora flavescens, 8-20 parts of camphor, 90-120 parts of herba agrimoniae, 8-20 parts of alumen, 90-120 parts of radix stemonae, 3-6 parts of borneol, 90-120 parts of common cnidium fruit and 4-7 parts of benzalkonium bromide. The dampness removing and parasite destroying traditional Chinese medicine composition has efficacies of heat clearing, detoxicating, parasite destroying and itching relieving and is applicable to bacterial vaginitis with downward flow of dampness and heat, colpomycosis and trichomonas vaginitis, and according to clinical observation, curative effects are obvious, and no toxic or side effect is found.

The invention discloses a rapid hemostatic product for clinical operation wounds, as well as a preparation method and application of the rapid hemostatic product. The rapid hemostatic product comprises a matrix containing a microbial transglutaminase (mT6), wherein the amino acid sequence of the transglutaminase is the protein sequence coded by the gene shown in SEQ ID NO.: 3, or the protein sequence shown in SEQ ID NO.: 4. Specifically, the rapid hemostatic product is selected from a hemostatic, a hemostatic device, a hemostatic first-aid kit or a common hemostatic product; the matrix adopts a fluid or semisolid form, which can be absorbed by a human body, or a plastic gel or colloid form. The rapid hemostatic product contains the microbial transglutaminase and gelatin. The rapid hemostatic product has the advantages of rapid hemostatic property, convenience for use, prevention on organ adhesion, promotion on wound healing, low toxic and side effects, complete absorption and the like. The rapid hemostatic product can be used as a medical hemostatic material or product for clinical operation wounds, can stop bleeding rapidly, prevents organ adhesion, is easy to absorb, has little possibility of spreading diseases, and is low in cost.

A vaginal IgY effervescent tablet specifically to kill Candida albicans for treating mycotic vaginitis of woman, even if gravida and puerpera, is disclosed.

The invention belongs to the technical field of weight reducing medicines, and provides a pharmaceutical composition with a fat reducing effect. The pharmaceutical composition with the fat reducing effect comprises a photosensitizer and rosiglitazone; the photosensitizer comprises one or a mixture of more of photoporphyrin, viltipofen, temopofen, chlorin e6, zinc phthalocyanine and 5-aminolevulinic acid; and the mass ratio of the photosensitizer to the rosiglitazone is 3: 1-10: 1. When the pharmaceutical composition is applied, the pharmaceutical composition powder is diluted and dissolved bynormal saline, and then the pharmaceutical composition is administrated in an intravenous injection mode. Photodynamic cell killing of the photosensitizer is combined with cell browning induction of the rosiglitazone, so that an optimal weight losing strategy combining 'fast and slow ' and 'local and integrity' is realized. The two drug effects are good complementary pairs, and experimental results show that the two drug effects have quite good synergistic effects. In addition, the rosiglitazone also has an obvious inhibition effect on adverse reactions possibly caused by photosensitizer treatment.

The invention relates to clindamycin phosphate freeze-drying powder for injection. The clindamycin phosphate freeze-drying powder for injection is prepared from the following components in parts by weight: 100 parts of clindamycin phosphate, 5 to 15 parts of sodium chloride, 2 to 6 parts of mannitol, and 10 to 30 parts of sodium hydroxide. A preparation method comprises the steps of preparing rawmaterials; preparing a medicine liquid; filtering; sub-packaging in a sterile way; vacuum freeze drying and packaging, wherein vacuum freeze drying comprises pre-freezing, one-stage drying, two-stagedrying, three-stage drying and four-stage drying. According to the clindamycin phosphate freeze-drying powder for injection provided by the invention, through adjusting and accurately controlling a product recipe, processing steps and control parameters, the stability performance of the product is further ensured; through the sufficient verification of a stability test, an acceleration test and along-term test, the clindamycin phosphate freeze-drying powder prepared by adopting the method provided by the invention is not changed in appearance, remarkably increased in related substances, and remarkably reduced in main content, so that the storage stability and the clinic application safety of the clindamycin phosphate freeze-drying powder are ensured maximally.

The invention discloses a traditional Chinese medicine preparation for resolving phlegm to relieve the cough and a preparation method thereof. The preparation is prepared from the following components in parts by weight: 210 to 240 parts of radix platycodonis, 100 to 130 parts of liquorice roots, 70 to 90 parts of a radix polygalae liquid extract, 0.5 to 0.8 part of menthol, 1.2 to 1.4 parts of mandarin oil, 4 to 6 parts of ephedrine hydrochloride, 45 to 65 parts of a radix stemonae liquid extract, 12 to 16 parts of beta-cyclodextrin, 40 to 60 parts of polyvinylpolypyrrolidone, 10 to 20 parts of hydroxypropyl methyl cellulose, 100 to 200 parts of pregelatinized starch, 15 to 25 parts of sodium carboxymethyl starch, 12 to 16 parts of lauryl sodium sulfate and 3 to 5 parts of superfine silica powder. The preparation is made into dispersible tablets. The preparation method of the preparation comprises the steps of preparing a thick paste from the radix platycodonis and the liquorice roots through extraction, then preparing dry paste powder from the radix polygalae liquid extract, the ephedrine hydrochloride and the radix stemonae liquid extract together with the thick paste, preparing an inclusion from the menthol and the mandarin oil, and further preparing the dispersible tablets. According to the traditional Chinese medicine preparation, the disintegration time limit can be obviously shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost and low in energy consumption, thereby being favorable for realizing industrial production.

The invention relates to a special health-care medicinal liquor for treatment of lumbar disc herniation and rheumatic bone diseases. The special health-care medicinal liquor mainly overcomes the problems of slow treatment effect and long treatment course of conventional drugs. The special health-care medicinal liquor is characterized by comprising, by weight, 18 to 28 parts of Cortex Illicii, 17 to 27 parts of obscured homalomena rhizomes, 15 to 25 parts of Mongolian jurinea tomentum, 500 parts of liquor and 3 to 5 parts of scorpion. The special health-care medicinal liquor of the invention has the advantages of obvious treatment effect, fast action, small possibility of recurrence, short treatment period and convenient treatment.

The present invention provides a clenbuterol aerosol inhalation solution preparation and a preparation method thereof. The clenbuterol aerosol inhalation solution preparation comprises clenbuterol, astabilizer, an osmotic pressure regulator, an appropriate amount of a pH regulator, and water. The clenbuterol aerosol inhalation solution preparation is reasonable in compositions, uses an atomized inhalation manner to conduct direct inhalation from mouth and nose, can avoid a first-pass effect of the liver and destruction and degradation of gastrointestinal tract, greatly reduces drug metabolismprocesses of the liver and kidneys, reduces organ damages to patients, is even in drug distribution, has a drug average particle diameter of about 0.2 [mu]m and a ratio of inhalable particles as highas 74% or more, is quick in taking effect, simple in the preparation method and low in cost, and has a very good development prospect.