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Gynecological antipruritic tablet and preparation method thereof

An antipruritic and gynecological technology, applied in the field of pharmaceuticals, can solve the problems of difficult to guarantee, unsatisfactory and incomplete extraction of active ingredients, etc., and achieve the effect of convenient taking, low production cost and fast onset of action

Pending Publication Date: 2019-10-01
广西万寿堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the traditional Chinese medicinal materials used in the original preparation process except Corydalis Corydalis (vinegar broiled) raw medicine powder are used as medicine, the other seven medicines are all extracted with water, the extraction of active ingredients is incomplete, and the efficacy of the medicine is difficult to guarantee, and it is also unable to meet the requirements of impurities in Chinese medicine extracts during the preparation of dispersible tablets. minimal requirements

Method used

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  • Gynecological antipruritic tablet and preparation method thereof
  • Gynecological antipruritic tablet and preparation method thereof
  • Gynecological antipruritic tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] R1. Take Patrinia, Hedyotis diffusa, Dandelion, Hengjingxi, Rubia, Millae, Angelica, Corydalis (roasted with vinegar), cleanly select, and dry;

[0093] R2. Weigh the components according to the following parts by weight: Patrinia 435g, Hedyotis diffusa 435g, Dandelion 435g, Hengjing Mat 150g, Rubia 435g, Millipede Spatholobus 435g, Angelica 290g, Corydalis Corydalis (roasted with vinegar) 100g;

[0094] R3. Preparation of medicinal material extract dry cream powder: take Patrinia, Hedyotis diffusa, Dandelion, Materia Medica, Rubia, Spatholobus, Angelica, Corydalis (roasted with vinegar) and add 5 times the amount of 70% ethanol solution and heat to reflux for 2 hours , filtered, and the dregs are set aside, and the ethanol is recovered from the filtrate until it has no alcohol smell, and the alcohol extract is obtained; take the dregs, add water to decoct twice, add 8 times the amount of water to decoct for 2 hours for the first time, and add 6 times the amount for the ...

Embodiment 2

[0101] R1. Take Patrinia, Hedyotis diffusa, Dandelion, Hengjingxi, Rubia, Millae, Angelica, Corydalis (roasted with vinegar), cleanly select, and dry;

[0102] R2. Weigh the components according to the following parts by weight: Patrinia 435g, Hedyotis diffusa 435g, Dandelion 435g, Hengjing Mat 150g, Rubia 435g, Millipede Spatholobus 435g, Angelica 290g, Corydalis Corydalis (roasted with vinegar) 100g;

[0103] R3. Preparation of medicinal material extract dry cream powder: take Patrinia, Hedyotis diffusa, Dandelion, Materia Medica, Rubia, Spatholobus, Angelica, Corydalis (roasted with vinegar) and add 8 times the amount of 70% ethanol solution and heat to reflux for 2 hours , filtered, and the dregs are set aside, the filtrate recovers ethanol until there is no alcohol smell, and the alcohol extract is obtained; take the dregs, add water to decoct 2 times, add 10 times the amount of water to decoct for 2 hours for the first time, and add 7 times the amount for the second time ...

Embodiment 3

[0110] R1. Take Patrinia, Hedyotis diffusa, Dandelion, Hengjingxi, Rubia, Millae, Angelica, Corydalis (roasted with vinegar), cleanly select, and dry;

[0111] R2. Weigh the components according to the following parts by weight: Patrinia 435g, Hedyotis diffusa 435g, Dandelion 435g, Hengjing Mat 150g, Rubia 435g, Millipede Spatholobus 435g, Angelica 290g, Corydalis Corydalis (roasted with vinegar) 100g;

[0112] R3. Preparation of dry paste powder of medicinal material extracts: take Patrinia, Hedyotis diffusa, Dandelion, Materia Medica, Rubia, Spatholobus, Angelica, Corydalis (roasted with vinegar) and add 6 times the amount of 70% ethanol solution and heat to reflux for 2 hours , filtered, and the dregs are set aside, the filtrate recovers ethanol until there is no alcohol smell, and the alcohol extract is obtained; take the dregs, add 8 times the amount of water to decoct 2 times, each time for 2 hours, combine the filtrate, filter, and extract the alcohol extract from the fi...

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Abstract

The invention discloses a gynecological antipruritic tablet and a preparation method thereof. The gynecological antipruritic tablet is mainly prepared from, by weight, 435 parts of herba patriniae, 435 parts of spreading hedyotis herb, 435 parts of dandelions, 150 parts of membranaceous beautyleaf roots, 435 parts of radix rubiae, 435 parts of caulis spatholobi, 290 parts of angelica sinensis and100 parts of rhizoma corydalis (stir-baking with vinegar). The gynecological antipruritic tablet produced by the preparation method has the advantages that the disintegration speed is high, the dissolution is better, the absorption is faster, the action is fast, the bioavailability is high, the adverse reactions are few, and taking is convenient; pharmacological experiment results show that the gynecological antipruritic tablet is superior to a gynecological antipruritic tablet prepared by a traditional method in inflammation resistance, bacteriostasis and other aspects; clinical trial resultsshow that the gynecological antipruritic tablet has a better curative effect on the treatment of damp-heat type elytritis, is safe and reliable to take, and has no side effects.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a gynecological antipruritic tablet and a preparation method thereof. Background technique [0002] Dispersible tablets, also known as water dispersible tablets, refer to tablets that can be rapidly disintegrated in contact with water to form a uniform viscous suspension. Compared with ordinary tablets, dispersible tablets can increase the dissolution of insoluble drugs, absorb quickly, have high bioavailability, have less adverse reactions, and can reduce the irritation of drugs to the gastrointestinal tract. Dispersible tablets are easy to take, can be swallowed, chewed, sucked, or can be dispersed in water and taken alone or with fruit juice or milk, especially suitable for the elderly, young and patients who have difficulty swallowing solids. [0003] The prescription of Fuke Zhiyang Tablets is recorded in the National Drug Standard WS-5806(B-0806)-2002. The prescription mainly incl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/84A61K9/20A61K47/32A61K47/38A61K47/36A61K47/12A61K47/02A61P17/04A61P15/02A61P29/00A61P31/10A61P31/04
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/205A61K9/2054A61K36/232A61K36/288A61K36/38A61K36/486A61K36/66A61K36/74A61K36/748A61K36/84A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P15/02A61P17/04A61P29/00A61P31/04A61P31/10A61K2300/00
Inventor 农常东黄艳妮毛金玲
Owner 广西万寿堂药业有限公司
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