Traditional Chinese medicine preparation for resolving phlegm to relieve cough and preparation method thereof

A technology of traditional Chinese medicine preparations, eliminating phlegm and relieving cough, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. None, the effect of reducing moisture absorption

Inactive Publication Date: 2017-11-03
广西大海阳光药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The preparation process of the original dosage form is that bellflower and licorice are crushed into fine powder without extraction and directly used as medicine. Although the active ingredients of the medicine are guaranteed, there are also many impurities, which cannot meet the requirements of the preparation of dispersible tablets. The content of active ingredients and the requirements for medicinal effects

Method used

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  • Traditional Chinese medicine preparation for resolving phlegm to relieve cough and preparation method thereof
  • Traditional Chinese medicine preparation for resolving phlegm to relieve cough and preparation method thereof
  • Traditional Chinese medicine preparation for resolving phlegm to relieve cough and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0070] A preparation method of dispersible tablets prepared from a traditional Chinese medicine preparation for eliminating phlegm and relieving cough comprises the following steps:

[0071] T1. Take the following components: β-cyclodextrin, crospovidone, hydroxypropyl methyl cellulose, pregelatinized starch, sodium carboxymethyl starch, sodium lauryl sulfate, micronized silica gel, crushed Pass a 100-mesh sieve for use;

[0072] T2. Weigh the components in the following parts by weight: Platycodon grandiflorum 2100g, licorice 1000g, Polygalaceae extract 700g, menthol 5g, orange oil 12g, ephedrine hydrochloride 40g, Baibuliu extract 450g, β-cyclodextrin 120g, Cross-linked povidone 400g, hydroxypropyl methylcellulose 100g, pregelatinized starch 1000g, sodium carboxymethyl starch 150g, sodium lauryl sulfate 120g, micronized silica gel 30g;

[0073] T3. Preparation of dry powder of medicinal extract: take Platycodon grandiflorum and Glycyrrhiza medicinal materials, crush them into 10 m...

Embodiment 2

[0079] A preparation method for preparing dispersible tablets from a traditional Chinese medicine for eliminating phlegm and relieving cough comprises the following steps:

[0080] T1. Take the following components: β-cyclodextrin, crospovidone, hydroxypropyl methyl cellulose, pregelatinized starch, sodium carboxymethyl starch, sodium lauryl sulfate, micronized silica gel, crushed Pass a 100-mesh sieve for use;

[0081] T2. Weigh the components according to the following parts by weight: Platycodon grandiflorum 2400g, licorice 1300g, Polygalaceae extract 900g, menthol 8g, orange oil 14g, ephedrine hydrochloride 60g, Baibuliu extract 650g, β-cyclodextrin 160g, 600g of crospovidone, 200g of hydroxypropyl methylcellulose, 2000g of pregelatinized starch, 250g of sodium carboxymethyl starch, 160g of sodium lauryl sulfate, 50g of micronized silica gel;

[0082] T3. Preparation of dry powder of medicinal extracts: take Platycodon grandiflorum and licorice herbs, crush them into 8 mesh coar...

Embodiment 3

[0088] A preparation method of dispersible tablets prepared from a traditional Chinese medicine preparation for eliminating phlegm and relieving cough comprises the following steps:

[0089] T1. Take the following components: β-cyclodextrin, crospovidone, hydroxypropyl methyl cellulose, pregelatinized starch, sodium carboxymethyl starch, sodium lauryl sulfate, micronized silica gel, crushed Pass a 100-mesh sieve for use;

[0090] T2. Weigh the following components: Platycodon grandiflorum 2250g, licorice 1130g, Polygalaceae extract 800g, menthol 6.7g, orange oil 13g, ephedrine hydrochloride 50g, Baibuliu extract 550ml, β-cyclodextrin 140g , Cross-linked povidone 500g, hydroxypropyl methylcellulose 150g, pregelatinized starch 1500g, sodium carboxymethyl starch 200g, sodium lauryl sulfate 140g, micronized silica gel 40g;

[0091] T3. Preparation of dry powder of medicinal extract: take Platycodon grandiflorum and Glycyrrhiza medicinal materials, crush them into 9 mesh coarse powder, a...

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Abstract

The invention discloses a traditional Chinese medicine preparation for resolving phlegm to relieve the cough and a preparation method thereof. The preparation is prepared from the following components in parts by weight: 210 to 240 parts of radix platycodonis, 100 to 130 parts of liquorice roots, 70 to 90 parts of a radix polygalae liquid extract, 0.5 to 0.8 part of menthol, 1.2 to 1.4 parts of mandarin oil, 4 to 6 parts of ephedrine hydrochloride, 45 to 65 parts of a radix stemonae liquid extract, 12 to 16 parts of beta-cyclodextrin, 40 to 60 parts of polyvinylpolypyrrolidone, 10 to 20 parts of hydroxypropyl methyl cellulose, 100 to 200 parts of pregelatinized starch, 15 to 25 parts of sodium carboxymethyl starch, 12 to 16 parts of lauryl sodium sulfate and 3 to 5 parts of superfine silica powder. The preparation is made into dispersible tablets. The preparation method of the preparation comprises the steps of preparing a thick paste from the radix platycodonis and the liquorice roots through extraction, then preparing dry paste powder from the radix polygalae liquid extract, the ephedrine hydrochloride and the radix stemonae liquid extract together with the thick paste, preparing an inclusion from the menthol and the mandarin oil, and further preparing the dispersible tablets. According to the traditional Chinese medicine preparation, the disintegration time limit can be obviously shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost and low in energy consumption, thereby being favorable for realizing industrial production.

Description

Technical field [0001] The invention belongs to the field of medicines, and relates to a medicine and a preparation method thereof, in particular to a traditional Chinese medicine preparation for expectorating and relieving cough and a preparation method thereof. Background technique [0002] Juyuan cough tablets are included in the standards of the State Food and Drug Administration, the standard number is WS-11153(ZD-1153)-2002-2011Z, and the prescription is: Platycodon grandiflorum 225g, Polygalaceae extract 75ml, Baibeliu extract 50ml, 5g of ephedrine hydrochloride, 0.67g of menthol, 1.3g of orange oil, and 113g of licorice are made into plain tablets or film-coated tablets. It has the effect of expelling phlegm and relieving cough, and it is clinically used to treat cough with excessive sputum and uncomfortable sputum. Due to the existing preparation technology and other reasons, the film tablets of Juyuan Cough Tablets have problems such as long disintegration time limit, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/20A61K47/69A61P11/14A61P11/10A61K31/045A61K31/137
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/2054A61K9/2059A61K31/045A61K31/137A61K36/346A61K36/484A61K36/69A61K36/752A61K36/904A61K2300/00
Inventor 黄大权邓春霞唐新
Owner 广西大海阳光药业有限公司
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