Traditional Chinese medicine preparation for resolving phlegm to relieve cough and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation for resolving phlegm to relieve the cough and a preparation method thereof. The preparation is prepared from the following components in parts by weight: 210 to 240 parts of radix platycodonis, 100 to 130 parts of liquorice roots, 70 to 90 parts of a radix polygalae liquid extract, 0.5 to 0.8 part of menthol, 1.2 to 1.4 parts of mandarin oil, 4 to 6 parts of ephedrine hydrochloride, 45 to 65 parts of a radix stemonae liquid extract, 12 to 16 parts of beta-cyclodextrin, 40 to 60 parts of polyvinylpolypyrrolidone, 10 to 20 parts of hydroxypropyl methyl cellulose, 100 to 200 parts of pregelatinized starch, 15 to 25 parts of sodium carboxymethyl starch, 12 to 16 parts of lauryl sodium sulfate and 3 to 5 parts of superfine silica powder. The preparation is made into dispersible tablets. The preparation method of the preparation comprises the steps of preparing a thick paste from the radix platycodonis and the liquorice roots through extraction, then preparing dry paste powder from the radix polygalae liquid extract, the ephedrine hydrochloride and the radix stemonae liquid extract together with the thick paste, preparing an inclusion from the menthol and the mandarin oil, and further preparing the dispersible tablets. According to the traditional Chinese medicine preparation, the disintegration time limit can be obviously shortened, and the bioavailability is improved. The preparation method is simple in process, low in production cost and low in energy consumption, thereby being favorable for realizing industrial production.

Description

Technical field [0001] The invention belongs to the field of medicines, and relates to a medicine and a preparation method thereof, in particular to a traditional Chinese medicine preparation for expectorating and relieving cough and a preparation method thereof. Background technique [0002] Juyuan cough tablets are included in the standards of the State Food and Drug Administration, the standard number is WS-11153(ZD-1153)-2002-2011Z, and the prescription is: Platycodon grandiflorum 225g, Polygalaceae extract 75ml, Baibeliu extract 50ml, 5g of ephedrine hydrochloride, 0.67g of menthol, 1.3g of orange oil, and 113g of licorice are made into plain tablets or film-coated tablets. It has the effect of expelling phlegm and relieving cough, and it is clinically used to treat cough with excessive sputum and uncomfortable sputum. Due to the existing preparation technology and other reasons, the film tablets of Juyuan Cough Tablets have problems such as long disintegration time limit, ...

AI Technical Summary

Problems solved by technology

[0004] The preparation process of the original dosage form is that bellflower and licorice are crushed into fine powder without extraction and directly used as medicine. Although the active ingredients of the medicine are guaranteed, there are also many impurities, which cannot meet the requirements of the preparation of dispersible tablets. The content of active ingredients and the requirements for medicinal effects

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