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Preparation method of pearl layer powder-wild chrysanthemum cream powder hypotensive tablet

The technology of Zhenju Jiangya tablet and nacre powder is applied in the field of preparation of Zhenju Jiangya tablet, which can solve the problems of uneven mixing of clonidine hydrochloride, substandard content uniformity, etc., so as to improve bioavailability and increase batch size. Productivity, the effect of improving mixing uniformity

Inactive Publication Date: 2013-03-20
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the mixing process of this process method, the chrysanthemum flower paste powder is easy to wrap clonidine hydrochloride, so that the clonidine hydrochloride is mixed unevenly, and the content uniformity is not up to standard

Method used

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  • Preparation method of pearl layer powder-wild chrysanthemum cream powder hypotensive tablet
  • Preparation method of pearl layer powder-wild chrysanthemum cream powder hypotensive tablet
  • Preparation method of pearl layer powder-wild chrysanthemum cream powder hypotensive tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1, a Zhenju Jiangya tablet (batch number: 101101, 10,000 tablets in total), the formula is:

[0035] Wild Chrysanthemum Cream Powder 1000g

[0036] Pearl layer powder 1000g

[0037] Clonidine Hydrochloride 300mg

[0038] Hydrochlorothiazide 50g

[0039] Rutin 200g

[0040] Its preparation method is as follows:

[0041] (1) Take 50.6g of hydrochlorothiazide and 999.7g of nacre powder and mix them in equal increments to obtain a mixed powder;

[0042] (2) Take another 0.295 g of clonidine hydrochloride, add ethanol with a volume concentration of 70% to dissolve, mix the obtained solution evenly into the above mixed powder, and stir repeatedly to obtain a mixture;

[0043] (3) Dry the above mixture at a temperature of 40-60°C, and pulverize it into powder in a pulverizer, and pass through a No. 5 sieve;

[0044] (4) Take 999.8g of wild chrysanthemum paste powder and 200.1g of rutin and add it to the above-mentioned powder passed through a No. 5 sieve, mix and...

Embodiment 2

[0065] Example 2, a Zhenju Jiangya tablet (batch number: 101102, 10,000 tablets in total), the formula is:

[0066] Wild Chrysanthemum Cream Powder 1000g

[0067] Pearl layer powder 1000g

[0068] Clonidine Hydrochloride 300mg

[0069] Hydrochlorothiazide 50g

[0070] Rutin 200g

[0071] Its preparation method is as follows:

[0072] (1) Take 50.7g of hydrochlorothiazide and 1000.1g of nacre powder and mix them in equal increments;

[0073] (2) Take another 0.312g of clonidine hydrochloride, add ethanol with a volume concentration of 70% to dissolve, mix the obtained solution evenly into the above mixed powder, and repeatedly stir the mixture;

[0074] (3) Dry the above mixture at a temperature of 40-60°C, and pulverize it into powder in a pulverizer;

[0075] (4) Add 1000.1g of wild chrysanthemum paste powder and 200.1g of rutin to the crushed powder, mix and granulate;

[0076] (5) Press into 10,000 tablets, and coat the compressed tablets, and the weight of the coati...

Embodiment 3

[0097] Example 3, a Zhenju Jiangya tablet (batch number: 101103, 10,000 tablets in total), the formula is:

[0098] Wild Chrysanthemum Cream Powder 1000g

[0099] Pearl layer powder 1000g

[0100] Clonidine Hydrochloride 300mg

[0101] Hydrochlorothiazide 50g

[0102] Rutin 200g

[0103] The preparation method is as follows:

[0104] (1) Take 49.9g of hydrochlorothiazide and 1000.4g of nacre powder and mix them in equal increments;

[0105] (2) Take another 0.312g of clonidine hydrochloride, add ethanol with a volume concentration of 70% to dissolve, mix the obtained solution evenly into the above mixed powder, and repeatedly stir the mixture;

[0106] (3) Dry the above mixture at a temperature of 40-60°C, and pulverize it into powder in a pulverizer;

[0107] (4) Add 1000.1g of wild chrysanthemum paste powder and 299.9g of rutin to the crushed powder, mix and granulate;

[0108] (5) Pressing into tablets and coating, the coating weight is 2% to 3% of the total weight o...

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Abstract

The invention discloses a preparation method of a pearl layer powder-wild chrysanthemum cream powder hypotensive tablet. The preparation method comprises the following steps of 1, carrying out equivalent incremental mixing of hydrochlorothiazide and pearl layer powder to obtain mixed powder, 2, dissolving clonidine hydrochloride by ethanol having a volume concentration of 70% to obtain a solution, uniformly mixing the solution and the mixed powder obtained by the step 1, and repeatedly stirring to obtain a mixture, 3, drying the mixture obtained by the step 2 at a temperature of 40 to 60 DEG C and crushing the dried mixture into powder, 4, adding wild chrysanthemum cream powder and rutin into the powder obtained by the step 3, mixing, and carrying out granulation, and 5, carrying out tabletting and coating. Clonidine hydrochloride is dissolved by ethanol and then is uniformly mixed with hydrochlorothiazide and pearl layer powder; the mixture is dried, crushed and is uniformly mixed with wild chrysanthemum cream powder and rutin; and the mixture is processed into particles. The preparation method can effectively prevent that clonidine hydrochloride is coated by wild chrysanthemum cream powder, improve mixing uniformity and improve bioavailability of the pearl layer powder-wild chrysanthemum cream powder hypotensive tablet.

Description

[0001] technical field [0002] The invention relates to a medicine for treating hypertension, in particular to a preparation method of Zhenju Jiangya Tablet. Background technique [0003] With the improvement of people's living standards and changes in lifestyle, essential hypertension presents a gradually increasing trend. In October 2004, the state released the "Investigation Report on the Nutrition and Health Status of Chinese Residents" which pointed out that the prevalence rate of hypertension among adults in my country is 18.8%, and it is estimated that there are 160 million existing patients in the country, an increase of more than 7,000 compared with 1991. Ten thousand. There is currently no cure for essential hypertension, but large-scale clinical trials have shown that a decrease in systolic blood pressure of 10-20 mmHg or diastolic blood pressure of 5-6 mmHg will lead to stroke, cardiovascular and cerebrovascular disease mortality and coronary heart disease event...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61K9/28A61P9/12A61K31/4168A61K31/549A61K31/7048A61K35/56A61K35/618
Inventor 吴渝飞
Owner TIANSHENG PHARMA GROUP
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