Preparation method of pearl layer powder-wild chrysanthemum cream powder hypotensive tablet
The technology of Zhenju Jiangya tablet and nacre powder is applied in the field of preparation of Zhenju Jiangya tablet, which can solve the problems of uneven mixing of clonidine hydrochloride, substandard content uniformity, etc., so as to improve bioavailability and increase batch size. Productivity, the effect of improving mixing uniformity
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Example Embodiment
[0034] Embodiment 1, a kind of Zhenju antihypertensive tablet (batch number: 101101, a total of 10000 tablets), the formula is:
[0035] Wild Chrysanthemum Cream Powder 1000g
[0036] Nacre Powder 1000g
[0037] Clonidine Hydrochloride 300mg
[0038] Hydrochlorothiazide 50g
[0039] Rutin 200g
[0040] Its preparation method is as follows:
[0041] (1) Mix 50.6 g of hydrochlorothiazide and 999.7 g of nacre powder in equal amounts to obtain a mixed powder;
[0042] (2) Separately take 0.295 g of clonidine hydrochloride, add 70% ethanol to dissolve, stir the obtained solution into the above mixed powder evenly, and stir repeatedly to obtain a mixture;
[0043] (3) Dry the above mixture at a temperature of 40-60 °C, pulverize it into powder in a pulverizer, and pass it through a No. 5 sieve;
[0044] (4) Add 999.8 g of wild chrysanthemum ointment powder and 200.1 g of rutin to the above-mentioned powder that has passed through the No. 5 sieve, mix and granulate;
[0045] (...
Example Embodiment
[0065] Embodiment 2, a kind of Zhenju Jiangya tablet (batch number: 101102, a total of 10000 tablets), the formula is:
[0066] Wild Chrysanthemum Cream Powder 1000g
[0067] Nacre Powder 1000g
[0068] Clonidine Hydrochloride 300mg
[0069] Hydrochlorothiazide 50g
[0070] Rutin 200g
[0071] Its preparation method is as follows:
[0072] (1) Take the mixed powder of 50.7g hydrochlorothiazide and 1000.1g nacre powder mixed in equal amounts;
[0073] (2) Separately take 0.312 g of clonidine hydrochloride, add 70% ethanol to dissolve it, stir the obtained solution into the above mixed powder evenly, and stir the mixture repeatedly;
[0074] (3) Dry the above mixture at a temperature of 40-60 °C, and pulverize it into powder in a pulverizer;
[0075] (4) Add 1000.1 g of wild chrysanthemum ointment powder and 200.1 g of rutin to the above-mentioned pulverized powder, mix and granulate;
[0076] (5) Compress into 10,000 tablets, and coat the compressed tablets, and the weig...
Example Embodiment
[0097] Embodiment 3, a kind of Zhenju antihypertensive tablet (batch number: 101103, a total of 10000 tablets), the formula is:
[0098] Wild Chrysanthemum Cream Powder 1000g
[0099] Nacre Powder 1000g
[0100] Clonidine Hydrochloride 300mg
[0101] Hydrochlorothiazide 50g
[0102] Rutin 200g
[0103] The preparation method is as follows:
[0104] (1) Take the mixed powder of 49.9g hydrochlorothiazide and 1000.4g nacre powder mixed in equal amounts;
[0105] (2) Separately take 0.312 g of clonidine hydrochloride, add 70% ethanol to dissolve it, stir the obtained solution into the above mixed powder evenly, and stir the mixture repeatedly;
[0106] (3) Dry the above mixture at a temperature of 40-60 °C, and pulverize it into powder in a pulverizer;
[0107] (4) Add 1000.1 g of wild chrysanthemum ointment powder and 299.9 g of rutin to the above crushed powder, mix and granulate;
[0108] (5) Tablet compression and coating, and the coating weight is 2% to 3% of the total...
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