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Amoxicillin dispersible tablet and production method thereof

A technology for amoxicillin and a production method, which is applied in the field of medicine and its production, can solve the problems of poor dissolution rate of amoxicillin, inconvenient quantitative use, influence on drug efficacy and the like, and achieves the effects of easy dissolving, easy quantitative use and easy molding

Active Publication Date: 2013-04-03
SHANXI TONGDA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the known amoxicillin is mostly in powder or granular form, which is inconvenient for quantitative use. In addition, due to the poor dissolution rate of amoxicillin in water, the purity in production and processing is poor, which affects the drug efficacy.

Method used

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Experimental program
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Embodiment Construction

[0006] Below in conjunction with embodiment the present invention is further described.

[0007] Preparation of Amoxicillin Dispersible Tablet Masterbatch Granules

[0008] Weigh 150.00kg of amoxicillin, 15.40kg of microcrystalline cellulose, 12.75kg of crospovidone, 9.35kg of low-substituted hydroxypropyl cellulose, and 3.20kg of croscarmellose sodium into the mixer, and dry mix After 15 minutes, add purified water, granulate with a 28-mesh nylon net, boil and dry the granules at 40-45° C., and sieve the dried granules through a 24-mesh sieve with vibration to prepare amoxicillin dispersible tablet masterbatch granules.

[0009] Preparation of Amoxicillin Dispersible Tablet Standby Material Granules

[0010] Weigh 2.30kg of sodium saccharin, 0.25kg of vanillin, 3.40kg of microcrystalline cellulose, and 3.40kg of low-substituted hydroxypropyl cellulose into the mixer, dry mix for 15 minutes, add 485ml of apricot essence, orange Flavoring essence 1200ml, after fully mixing, g...

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Abstract

The invention provides an amoxicillin dispersible tablet and a production method thereof. The production method comprises the following steps of respectively producing masterbatch particles, standby material particles and material particles from amoxicillin, microcrystalline cellulose, polyvinylpolypyrrolidone, low substituted hydroxyprepyl cellulose, croscarmellose sodium, magnesium stearate, silicon dioxide, saccharin sodium, vanillin, almond flavor essence and orange flavor essence raw and auxiliary materials in different proportions, and mixing in a certain proportion; and crushing, screening, magnetically screening, drying, granulating, weighing, adhering and tabletting to produce the amoxicillin dispersible tablet. The step of magnetic screening is added in the production method of the amoxicillin dispersible tablet production method, and iron powder, fine iron chips and the like possibly generated in crushing and screening the raw and auxiliary materials can be exhausted, so that the purity of the amoxicillin dispersible tablet can be guaranteed.

Description

technical field [0001] The invention relates to a medicine and its production, in particular to an antibiotic amoxicillin dispersible tablet and a production method thereof. Background technique [0002] At present, the known amoxicillin is mostly in powder or granular form, which is inconvenient for quantitative use. In addition, because amoxicillin has poor dissolution rate in water and poor purity in production and processing, it affects the drug efficacy. Contents of the invention [0003] The excipient microcrystalline cellulose is added to amoxicillin to make it easy to form tablets; Dissolve in water; add sodium saccharin, vanillin, apricot flavor, and orange flavor to adjust its taste to make it easy to take orally; add lubricant magnesium stearate and silicon dioxide to it to make it easy to release the mold; A magnetic sieve process is added during the processing of amoxicillin dispersible tablets, and the crushed and sieved raw and auxiliary materials are then ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/43A61K47/38
Inventor 闫亚梅
Owner SHANXI TONGDA PHARM CO LTD
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