Self-setting composite bone repair material for human body hard tissue repair and application

Abstract

The invention discloses a self-setting composite bone repair material for human body hard tissue repair and application. The self-setting composite bone repair material comprises solid-phase powder and a liquid phase, wherein the solid-phase powder contains 5-20% of tricalcium silicate, 30-70% of electric smelting magnesium oxide, 5-30% of calcium phosphate bone cement, 5-30% of potassium dihydrogen phosphate or ammonium dihydrogen phosphate, and retarder accounting for 2-10% of the weight of basic oxide, i.e. magnesium oxide; the liquid phase is selected from one or a mixture of more than one of deionized water, soluble phosphate, sodium alginate, citric acid, potassium citrate and chitosan; and the ratio of the liquid phase to the solid phase is 0.3-0.8ml/g, and the solid-phase powder and the liquid phase are uniformly blended. The bone cement material has good combination property; and as the initial setting time of the bone cement material is 3-20 minutes, the final settling time is 7-50 minutes, and the compressive strength is 10-50Mpa in 24 hours and 20-90Mpa in 72 hours, the bone cement material can meet the requirement of clinical application and is suitable for treating bone defect repair and osteoporosis and fixing and treating bone fractures in orthopedic departments, spine surgery, plastic surgery and stomatological departments.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a self-curing composite bone repair material for human hard tissue repair and a preparation method thereof. Background technique [0002] Irregular bone injuries, unstable fractures, and fracture repair and reconstruction caused by osteoporosis have always been difficult problems in the field of modern orthopedics. With the aggravation of population aging, the increasing number of cases of osteoporosis and bone injury, and the continuous improvement of people's living standards, the requirements for bone repair materials are becoming more and more stringent, so it is urgent to study related biomaterials. [0003] Traditional bone repair treatments include autologous bone graft, allogeneic bone graft and xenograft [1] . Autologous bone grafting is the "gold standard" for bone defect repair, but the source of autologous bone is limited, and it will cause some compl...

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Problems solved by technology

[0009] In view of the above problems, the present invention proposes to utilize the excellent mechanical properties of magnesium phosphate cement to strengthen calcium phosphate cement, utilize the main early-strength mineral tricalcium silicate of Portland cement to have good water resistance, improve the problem of poor water resistance of magnesium phosphate cement, and at the same time In view of the brittleness of inorganic self-curing materials, a composite curing liquid containing organic molecules is used to provide the toughness required by bone cement

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