Preparation method of CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer

A neurotransmitter and molecular imprinting technology, applied in the field of molecular imprinting technology, biological analysis and detection, and nanomaterials, can solve the problems of time-consuming, complicated operation and high cost, and achieve the effect of improving efficiency and rapid recombination.

Inactive Publication Date: 2013-04-03
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The object of the present invention is to provide a kind of CdTe / SiO 2 Molecularly imprinted polymers of monoamine neurotransmitters on the surface of quantum dots (CdTeSiO 2 MIPs) to explore a fast, simple, economical, and visual new analytical method for the determination of monoamine neurotransmitters, thereby improving the time-consuming, complex operation, and high cost of existing methods.

Method used

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  • Preparation method of CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer
  • Preparation method of CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer
  • Preparation method of CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer

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Embodiment 1

[0034] CdTe / SiO 2 The preparation method of the monoamine neurotransmitter molecularly imprinted polymer on the surface of quantum dots comprises the following steps:

[0035] (1) CdTeSiO 2 Preparation of quantum dots:

[0036] Accurately weigh 0.0574 g tellurium powder, 0. 2041 g NaBH 4 Into a 50 mL three-necked bottle, under a nitrogen atmosphere, inject 20 mL of freshly boiled and cooled distilled water, stir magnetically, and continue to pass nitrogen to react to obtain a light pink NaHTe solution for later use;

[0037] Add 270 mL of distilled water to another 500 mL three-necked flask, followed by adding 0.25 mol·L -1 Cd 2+ Mother liquor 6 mL, mercaptopropionic acid 627 μL, adjust pH to 9.0-10.0 with 1 mol / L NaOH, heat to 90-100°C in oil bath;

[0038] Then the NaHTe solution was introduced into a 500 mL three-neck flask, and after magnetic stirring for 10 min, 3.35 mL tetraethylorthosilicate was slowly injected, and the reaction was refluxed at 90-100 °C for 4 h u...

Embodiment 2

[0044] CdTe / SiO 2 The preparation method of the monoamine neurotransmitter molecularly imprinted polymer on the surface of quantum dots comprises the following steps:

[0045] (1) CdTeSiO 2 Preparation of quantum dots:

[0046] Accurately weigh 0.1531 g tellurium powder, 0.5443 g NaBH 4 Into a 50 mL three-necked bottle, under a nitrogen atmosphere, inject 20 mL of freshly boiled and cooled distilled water, stir magnetically, and continue to pass nitrogen to react to obtain a light pink NaHTe solution for later use;

[0047] Add 270 mL of distilled water to another 500 mL three-neck flask, followed by adding 0.25 mol·L -1 Cd 2+ Mother liquor 6 mL, mercaptopropionic acid 627 μL, adjust pH to 9.0-10.0 with 1 mol / L NaOH, heat to 90-100°C in oil bath;

[0048] Then the NaHTe solution was introduced into a 500 mL three-neck flask, and after magnetic stirring for 10 min, 3.35 mL tetraethylorthosilicate was slowly injected, and the reaction was refluxed at 90-100 °C for 4 h unde...

Embodiment 3

[0054] CdTe / SiO 2 The preparation method of the monoamine neurotransmitter molecularly imprinted polymer on the surface of quantum dots comprises the following steps:

[0055] (1) CdTeSiO 2 Preparation of quantum dots:

[0056] Accurately weigh 0.0574 g tellurium powder, 0. 2041 g NaBH 4 Into a 50 mL three-necked bottle, under a nitrogen atmosphere, inject 20 mL of freshly boiled and cooled distilled water, stir magnetically, and continue to pass nitrogen to react to obtain a light pink NaHTe solution for later use;

[0057] Add 270 mL of distilled water to another 500 mL three-neck flask, followed by adding 0.25 mol·L -1 Cd 2+ Mother liquor 6 mL, mercaptopropionic acid 627 μL, adjust pH to 9.0-10.0 with 1 mol / L NaOH, heat to 90-100°C in oil bath;

[0058] Then the NaHTe solution was introduced into a 500 mL three-neck flask, and after magnetic stirring for 10 min, 3.35 mL tetraethylorthosilicate was slowly injected, and the reaction was refluxed at 90-100 °C for 8 h und...

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Abstract

The invention discloses a preparation method of a CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer. The preparation method comprises the following steps of: synthesizing CdTe@SiO2 quantum dots in a water phase, carrying out rotary evaporation till water is completely volatized, and washing off unreacted substances by absolute ethyl alcohol; adding the obtained CdTe@SiO2 quantum dots to a pore-foaming agent, sequentially adding template molecules, functional monomers and a crosslinking agent after uniform ultrasonic dispersion, and stirring and reacting for 20 hours under the protection of N2; centrifuging a reaction liquid, discarding a supernatant, and washing obtained solids to remove the template molecules to obtain the CdTe@SiO2 quantum dot surface monoamine neurotransmitter molecularly imprinted polymer. The material synthesized by the method has the advantages that a quantum dot fluorescent probe is high in sensitivity and simple and convenient to detect and has the characteristics that the molecularly imprinted polymer is high in selectivity and affinity and can be directly used for determining monoamine neurotransmitters in biological fluids.

Description

[0001] technical field [0002] The invention belongs to the fields of nanomaterials, molecular imprinting technology and biological analysis and detection, and specifically relates to a CdTeSiO 2 A method for preparing a molecularly imprinted polymer of monoamine neurotransmitters on the surface of quantum dots. Background technique [0003] The central nervous system (CNS) controls the human consciousness , psychology , thinking Activities and specific behaviors are the command center of all human activities. Therefore, CNS-related diseases have a great impact on the work and life of patients. In recent years, the incidence of CNS diseases has been increasing year by year, and the pathogenesis is generally closely related to the dysfunction of neurons secreting neurotransmitters: for example, the decrease of 5-hydroxytryptamine and norepinephrine content can lead to depression; Changes in the content of GABA, aspartic acid, glycine and g-aminobutyric acid can induce ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G77/26C08G77/06C08G77/02C08J9/26
Inventor 胡琴魏芳弟吴燕子李瑞刘利萍周萍蔡政杨静
Owner NANJING MEDICAL UNIV
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