Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ceftazidime composition for injection and preparation method for ceftazidime composition

A technology of ceftazidime and composition, which is applied in the field of ceftazidime for injection and its preparation field, can solve the problems of easy occurrence of adverse reactions, poor stability and change of the composition at risk of drug use by patients, etc., so as to enhance the effect of solubilization and improve the heart and brain. The effect of blood supply and avoiding shortness of breath

Inactive Publication Date: 2013-04-10
HAINAN WEI KANG PHARMA QIANSHAN
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, in the market, ceftazidime powder for injection is added with arginine or sodium carbonate as co-solvent, but sodium carbonate will bring the risk of medication to patients and the problem of poor stability of the composition, while excessive intake of arginine will cause problems. May bring certain side effects, such as shortness of breath, itching, eczema, nausea and stomach pain, allergic reactions such as changes in blood chemicals, etc.
Also, people with liver and kidney disease are prone to adverse effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ceftazidime composition for injection and preparation method for ceftazidime composition
  • Ceftazidime composition for injection and preparation method for ceftazidime composition
  • Ceftazidime composition for injection and preparation method for ceftazidime composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription (specification: 2.0g):

[0038]

[0039] Preparation Process:

[0040] Sterilize the outer barrels of ceftazidime, arginine and lysine with 75% ethanol, and then irradiate them with ultraviolet light for more than 30 minutes. Sieve, then weigh the above-mentioned 3 kinds of materials of prescription quantity, set aside; Add ceftazidime, lysine, arginine to three-dimensional aseptic powder kinematic mixer successively, fully mix under rotating speed 30rmp-40rmp, 2-3 hours; Put the ceftazidime mixed powder into the filling machine, adjust the filling volume according to the batch production instructions, put it into the bottle after passing the inspection, and buckle the butyl rubber stopper; get it after crimping, light inspection, and packaging; among them, the powder is mixed and packed It is carried out under Class A clean area.

Embodiment 2

[0042] Prescription (specification: 2.0g):

[0043]

[0044] Preparation Process:

[0045] Sterilize the outer barrels of ceftazidime, arginine and lysine with 75% ethanol, and then irradiate them with ultraviolet light for more than 30 minutes. Sieve, then weigh the above-mentioned 3 kinds of materials of prescription quantity, set aside; Add ceftazidime, lysine, arginine to three-dimensional aseptic powder kinematic mixer successively, fully mix under rotating speed 30rmp-40rmp, 2-3 hours; Put the ceftazidime mixed powder into the filling machine, adjust the filling volume according to the batch production instructions, put it into the bottle after passing the inspection, and buckle the butyl rubber stopper; get it after crimping, light inspection, and packaging; among them, the powder is mixed and packed It is carried out under Class A clean area.

Embodiment 3

[0047] Prescription (specification: 2.0g):

[0048]

[0049] Preparation Process:

[0050] Sterilize the outer barrels of ceftazidime, arginine and lysine with 75% ethanol, and then irradiate them with ultraviolet light for more than 30 minutes. Sieve, then weigh the above-mentioned 3 kinds of materials of prescription quantity, set aside; Add ceftazidime, lysine, arginine to three-dimensional aseptic powder kinematic mixer successively, fully mix under rotating speed 30rmp-40rmp, 2-3 hours; Put the ceftazidime mixed powder into the filling machine, adjust the filling volume according to the batch production instructions, put it into the bottle after passing the inspection, and buckle the butyl rubber stopper; get it after crimping, light inspection, and packaging; among them, the powder is mixed and packed It is carried out under Class A clean area.

[0051] The present invention further provides the following test examples to illustrate the technical solution of the pr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a ceftazidime composition for injection and a preparation method for the ceftazidime composition, and relates to the technical field of medicines and medicine preparation methods. The problems of side effects, low safety and low stability and dissolubility of the conventional ceftazidime composition for injection are solved. The composition comprises the following components in parts by weight: 1 part of ceftazidime, 0.10 to 0.30 part of arginine and 0.10 to 0.30 part of lysine. The arginine and the lysine are used as cosolvents, so that the using amount of the arginine is reduced, and the co-dissolving effect can be enhanced; furthermore, the low tolerance of liver and kidney patients to the medicines caused by excessive arginine is improved; anaphylactic reactions such as polypnea, pruritus, eczema, nausea, stomachache and blood chemical change are avoided; and the safety and the stability are effectively improved.

Description

Technical field: [0001] The invention relates to the technical field of medicines and preparation methods of medicines, in particular to a ceftazidime composition for injection and a preparation method thereof. Background technique: [0002] Ceftazidime is a third-generation cephalosporin antibiotic with strong antibacterial activity and broad antibacterial spectrum, and has strong effects on Gram-positive or negative bacteria. It is highly stable to β-lactamase produced by Gram-positive bacteria and negative bacteria. The product is resistant to Pseudomonas aeruginosa, E. Corynebacterium, Neisseria meningitidis, Staphylococcus aureus, hemolytic streptococcus, pneumococcus, and Bacillus aerogenes have strong antibacterial activity, especially for Pseudomonas aeruginosa. [0003] Its chemical structural formula is: [0004] [0005] Its mechanism of action is: the antibacterial mechanism of ceftazidime is to affect the synthesis of bacterial cell walls. Similar to other...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/546A61K47/18A61P31/04
Inventor 汪六一汪金灿吴函峰李彪
Owner HAINAN WEI KANG PHARMA QIANSHAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com