Prokinetic traditional Chinese medicinal composition and preparation and application thereof
A technology of gastrointestinal motility and pharmaceutical preparations, applied in the field of traditional Chinese medicine, can solve problems such as drug resistance, Q-T interval prolongation, body dehydration, etc., and achieve the effect of broad market prospects, cheap raw materials, and simple preparation
Inactive Publication Date: 2013-04-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology
The second-generation prokinetic drug is domperidone, which is a peripheral dopamine receptor blocker. It is widely used clinically, mainly to promote gastric motility, but the effect of promoting intestinal motility is not good.
The third generation is cisapride, which is a kind of mehydroclopramide that replaces the alkylated benzodiazepines in its chemical structure. However, in recent years, it has been clinically found that Q-T interval prolongation or torsades de pointes can occur in patients with high sensitivity to cisapride. Tachycardia, for its further clinical application, there is still a lot of controversy
Relatively safe, common adverse reactions include gastric or esophageal and abdominal cramps, bo...
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0017] Weigh 3000g of raw Atractylodes macrocephala, 750g of citrus aurantium, and 1500g of raw Polygonum multiflorum, extract twice with water (52.5L, 1.5 hours; 42L, 1 hour), combine the extracts, concentrate, and dry to obtain a dry extract, crushed, and extracted The thing can be packaged and taken directly.
Embodiment 2
[0019] Weigh 3000g of Atractylodes Rhizoma Atractylodes Rhizome and 750g of Fructus Aurantii Fructus Aurantii, extract twice with water reflux (37.5L, 1.5 hours; 30L, 1 hour), combine the extracts, concentrate, dry to obtain a dry extract, crushed, and the extracts can be packaged directly , Chongfu.
Embodiment 3
[0021] Weigh 750g of Citrus aurantium and 1500g of raw Polygonum multiflorum, extract twice with water (22.5L, 1.5 hours; 16L, 1 hour), combine the extracts, concentrate, dry to obtain a dry extract, crushed, and the extracts can be packaged directly , Chongfu.
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The invention relates to the technical field of traditional Chinese medicines and provides a prokinetic traditional Chinese medicinal composition. The prokinetic traditional Chinese medicinal composition comprises the following two or three medicinal raw materials in part by weight: 1-120 parts of unprocessed rhizoma atractylodis, 1-30 parts of immature bitter orange and 1-60 parts of unprocessed polygonum multiflorum. The invention further provides a medicinal preparation with the prokinetic traditional Chinese medicinal composition as an active component, and application of the prokinetic traditional Chinese medicinal composition to preparation of medicines and food for treating or preventing irritable bowel syndrome, functional dyspepsia, functional abdominal distension, functional constipation and other gastrointestinal functional lesions.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for promoting gastrointestinal motility, its preparation and application. Background technique [0002] Gastrointestinal functional lesions are caused by disorders of neuromuscular tissue control in the gastrointestinal tract, and are mainly manifested by gastrointestinal symptoms such as pantothenic acid, abdominal distension, constipation, and diarrhea, and there are no structural or biochemical changes in routine examinations. Such as irritable bowel syndrome, functional dyspepsia, etc., are common clinical diseases. Decreased gastrointestinal motility is one of the main manifestations of gastrointestinal functional lesions, and clinical symptoms such as abdominal distension and constipation may appear. [0003] At present, there are four generations of gastrointestinal motility drugs commonly used clinically. T...
Claims
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Patent Timeline
Login to view more IPC IPC(8): A61K36/752A61K36/704A61P1/14A61P1/10A61P1/00A23L1/29A23L33/00
Inventor 岳小强刘继勇刘爱军
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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