A kind of composite polysaccharide hemostatic material and its preparation method and application

A technology of compound polysaccharide and hemostatic material, applied in the field of clinical surgery, can solve the problems of limited and limited effect, and achieve the effects of complete biodegradation and absorption, high safety and high liquid absorption rate

Active Publication Date: 2015-09-23
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the promotion of "Arista" hemostatic products, starch, as a safe and effective plant polysaccharide hemostatic material with a clear degradation mechanism in the body, has attracted people's attention. Cross-linking means to improve the liquid absorption of starch in order to improve the hemostatic performance, but the effect is limited due to the limitation of the performance of starch itself

Method used

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  • A kind of composite polysaccharide hemostatic material and its preparation method and application
  • A kind of composite polysaccharide hemostatic material and its preparation method and application
  • A kind of composite polysaccharide hemostatic material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Dissolve 8 grams of acid-thinned starch in 80ml of water, and stir for 4 hours at 60°C with an intensified agitator; dissolve 2g of sodium hyaluronate in 80ml of water, stir well, and mix the sodium hyaluronate solution with 1g of phosphorus oxychloride Add it to the starch solution, stir at 1000rpm for 30min and mix evenly; adjust the pH value of the solution to 9.0 with 1M NaOH, and stir at 1000rpm at 60°C for 15h with an intensified agitator; adjust the pH value of the solution to 6.8 with 1M HCl. After adding washing and refining, pour it into a freeze-drying tray, pre-freeze at -60 degrees Celsius for 3 hours, freeze-dry for 42 hours, smash into granules, and sterilize to obtain the product.

Embodiment 2

[0045] Dissolve 6 grams of potato starch in 70ml of water, and stir for 6 hours at 85°C with a booster stirrer; dissolve 1.5g of sodium hyaluronate in 60ml of water, stir well, and mix the sodium hyaluronate solution with 0.9g of glutaraldehyde And 1g of polyethylene glycol was added to the starch solution, stirred at 45°C for 10 hours with an intensified agitator at 1000rpm; added several times of pure water to wash and refine, poured into a freeze-drying tray, pre-frozen at -80°C for 3 hours, and freeze-dried at -40°C 56 hours, rolled into a film, and sterilized to obtain a product.

Embodiment 3

[0047]Dissolve 5 grams of cornstarch in 50ml of water, stir with a booster mixer at 75°C for 4 hours; dissolve 2g of sodium hyaluronate in 70ml of water, stir well, mix the sodium hyaluronate solution with 0.5g of sodium trimetaphosphate And 1.26g of glycerol was added to the starch solution, stirred at 1000rpm for 30min and mixed evenly; the pH value of the solution was adjusted to 11 with 1M NaOH, and the booster stirrer was stirred at 1000rpm at 60°C for 8h; the pH value of the solution was adjusted to 7.0 with 1M HCl. Add pure water to wash and refine, then pour into a freeze-drying tray, pre-freeze at -40°C for 8 hours, freeze-dry for 48 hours, and sterilize to obtain the product.

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Abstract

The invention relates to the field of a clinical surgery, and in particular relates to a compound polysaccharide hemostatic material. The compound polysaccharide hemostatic material comprises the following components in parts by weight: 5 to 75 parts of sodium hyaluronate, 10 to 85 parts of starch, 0 to 20 parts of plasticizer and 5 to 25 parts of cross-linking agent. According to the invention, sodium hyaluronate and starch are compositely cross-linked to obtain a porous support material, which is high in material liquid absorbing rate, fast in hemostasis and low amount of bleeding, so that a hemostatic effect is good. Meanwhile, sodium hyaluronate has the effects of endowing good anti-adhesion effect on the material, promotes wound healing and defected tissue repairing. The compound polysaccharide hemostatic material can be crushed in a granule or powder shape or ground in a soft sponge film shape, thereby being applied to the hemostasis of a traditional surgical operation, a minimally invasive surgery and trauma and wound tissue bleeding, being served as a filling and repairing and anti-adhesion material of defected tissues, and being served as a tissue engineer scaffold material, a medicine carrying support material and a wound dressing.

Description

technical field [0001] The invention relates to the field of clinical surgery, in particular to a composite polysaccharide hemostatic material, its application and a method for preparing the material. Background technique [0002] Bleeding is a common problem encountered in surgical operations, injury wounds and accidents, and sometimes even threatens life. Therefore, research on fast and effective hemostatic materials and methods has always been a subject of interest. With the improvement of people's material living conditions, people pay more attention to their own health, so higher requirements are put forward for the applicability and functionality of medical materials. In recent years, with the promotion of "Arista" hemostatic products, starch, as a safe and effective plant polysaccharide hemostatic material with a clear degradation mechanism in the body, has attracted people's attention. Cross-linking means to improve the liquid absorption of starch in order to improv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/20A61L27/54A61K47/36A61L15/28A61L15/44A61K31/728A61K31/718A61P41/00A61P7/04
Inventor 吴昌琳
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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