Medical polyvinyl alcohol sponge and preparation method

Abstract

The invention provides a medical polyvinyl alcohol sponge and a preparation method. The preparation method comprises the following steps: adding polyvinyl alcohol and starch into distilled water carrying out dissolving at 50 to 95 DEG C under stirring so as to obtain a mixed solution; adding a cross-linking agent, an emulsifier and a foam stabilizer into the mixed solution and carrying out stirring at 20 to 60 DEG C for 2 to 8 h so as to obtain a second mixed solution; adding an acidic catalyst into the second mixed solution and carrying out an acetalation cross-linking reaction at a constant temperature of 20 to 90 DEG C for 30 to 180 min so as to obtain emulsion-like liquid; and completion of the reaction, pouring the emulsion-like liquid into a mold, carrying out heating at 50 to 95 DEG C for curing, carrying out demoulding and washing after cooling, and then carrying out cutting and sterilization so as to obtain the medical polyvinyl alcohol sponge. The medical polyvinyl alcohol sponge prepared in the invention has a through hole structure, uniform pore diameter, good biocompatibility, excellent affinity, high porosity and fast liquid absorption rate, and is applicable to the field of surgical sciences, especially as a sponge consumable for vacuum sealing drainage.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a polyvinyl alcohol medical sponge and a preparation method thereof. Background technique [0002] Polyvinyl acetal superabsorbent sponge material (PVF sponge for short) has strong water absorption performance, high tensile strength, excellent biocompatibility, wear resistance, creep resistance, alkali resistance, good hydrophilicity, and is not easy to age And other advantages, it is widely used in the field of surgical medicine, especially in the negative pressure sealing drainage therapy, it plays the role of transmitting negative pressure and draining secretions. [0003] The sponge used in negative pressure sealing drainage therapy has many special requirements as follows: it must have a certain compressive elastic modulus to avoid hole collapse caused by negative pressure; it must have a certain pore size and a high degree of connectivity. The open pore structure of the...

AI Technical Summary

Problems solved by technology

If the starch forms closed cells inside the polyvinyl alcohol after the polyvinyl alcohol is solidified, it is difficult to clean the starch completely, and this kind of process starch has low utilization value and high water consumption, which is not conducive to saving resources and reducing costs

In addition, the application of Chinese Patent Publication No. CN1557872 discloses "superabsorbent polyvinyl alcohol foam and its preparation method". However, the sponge product obtained by foaming has a large cell diameter and is difficult to control evenly. Because sodium bicarbonate reacts strongly and rapidly with inorganic strong acids, a large amount of gas is released instantly, and the gas escapes seriously, so carbonic acid The addition of sodium hydrogen is relatively large, and more inorganic strong acid catalysts are also consumed. This method is difficult to be applied in industrial production.